Gene: IL36RN

26525
FIL1|FIL1(DELTA)|FIL1D|IL-36Ra|IL1F5|IL1HY1|IL1L1|IL1RP3|IL36RA|PSORP|PSORS14
interleukin 36 receptor antagonist
protein-coding
2q14.1
Ensembl:ENSG00000136695 MIM:605507 Vega:OTTHUMG00000131337 UniprotKB:Q9UBH0
NG_031864.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.290e-1 (AD)  5.043e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2472188chr2:113063237 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP630.668
DSC30.667
OR5M90.649
S100A7A0.644
OR51S10.635
OR9G40.634
OR8K10.626
PPP1R3A0.623
OR52R10.619
OR4L10.618

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SORCS2-0.381
ZNF835-0.347
ADCY2-0.339
NTSR2-0.329
ZFP41-0.329
LRRC8A-0.327
PTPRF-0.318
FAM86B1-0.318
C16orf95-0.315
ANO8-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of IL36RN mRNA19428942
D020106AcrylamideAcrylamide results in increased expression of IL36RN mRNA28959563
C006780bisphenol Abisphenol A results in decreased expression of IL36RN mRNA25181051
C020748ferrous sulfateferrous sulfate results in decreased expression of IL36RN mRNA19428942
D005557FormaldehydeFormaldehyde results in increased expression of IL36RN mRNA27664576
D008070LipopolysaccharidesTriclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL36RN mRNA]20507366
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in decreased expression of IL36RN mRNA17715259
D052638Particulate MatterParticulate Matter results in increased expression of IL36RN mRNA28341207
D052638Particulate MatterParticulate Matter results in increased expression of IL36RN mRNA24497439
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in decreased expression of IL36RN mRNA17715259
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IL36RN mRNA19428942
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL36RN mRNA25351596
D053260SootSoot results in decreased expression of IL36RN mRNA19428942
D014260TriclosanTriclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL36RN mRNA]20507366
D014635Valproic AcidValproic Acid results in increased methylation of IL36RN gene29154799
C016837zinc chloridezinc chloride results in decreased expression of IL36RN mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005149interleukin-1 receptor binding-IBA21873635  
GO:0005152interleukin-1 receptor antagonist activity-IEA-  
GO:0005515protein binding-IPI16189514  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001960negative regulation of cytokine-mediated signaling pathway-IBA21873635  
GO:0001960negative regulation of cytokine-mediated signaling pathway-IMP23147407  
GO:0002437inflammatory response to antigenic stimulus-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019732antifungal humoral response-IBA21873635  
GO:0019732antifungal humoral response-IMP23147407  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0032700negative regulation of interleukin-17 production-IBA21873635  
GO:0032700negative regulation of interleukin-17 production-IMP23147407  
GO:0032715negative regulation of interleukin-6 production-IBA21873635  
GO:0032715negative regulation of interleukin-6 production-IEA-  
GO:0032755positive regulation of interleukin-6 production-IBA21873635  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:0046330positive regulation of JNK cascade-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO:1902714negative regulation of interferon-gamma secretion-IBA21873635  
GO:1902714negative regulation of interferon-gamma secretion-IMP23147407  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-9014826Interleukin-36 pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal