Gene: TPK1

27010
HTPK1|PP20|THMD5
thiamin pyrophosphokinase 1
protein-coding
7q35
Ensembl:ENSG00000196511 MIM:606370 Vega:OTTHUMG00000152774 UniprotKB:Q9H3S4
NG_032112.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.143e-1 (AD)  2.827e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10224675chr7:144595669 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18956562chr7:144149304TPK12.000e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC270.851
ARMC80.844
EXOC80.843
EPM2AIP10.837
SLC25A360.837
TMX30.835
LGALS80.834
AGK0.833
BCAP290.832
MED60.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.433
OR4F29-0.414
MTRNR2L6-0.359
LYPD1-0.351
MTRNR2L9-0.342
MTRNR2L10-0.341
FOXJ1-0.336
NR0B1-0.321
AQP5-0.313
EYA2-0.31

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00152ThiamineSmall Molecule70-16-6Approved|Investigational|NutraceuticalTarget
DB04768Pyrithiamine PyrophosphateSmall Molecule-ExperimentalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPK1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TPK1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TPK1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TPK1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TPK1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TPK1 mRNA24449571
D001151ArsenicArsenic affects the methylation of TPK1 gene25304211
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TPK1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TPK1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of TPK1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TPK1 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TPK1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TPK1 mRNA19770486|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TPK1 mRNA20127859
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TPK1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of TPK1 mRNA23019147
D004958EstradiolEstradiol results in increased expression of TPK1 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of TPK1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TPK1 gene28505145
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TPK1 mRNA27858113
D002994ClofibrateClofibrate results in increased expression of TPK1 mRNA17585979
D003561CytarabineCytarabine results in decreased expression of TPK1 mRNA21198554
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TPK1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TPK1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TPK1 mRNA27392435|2759478
C024565ethylene dichlorideethylene dichloride results in decreased expression of TPK1 mRNA28189721
D005557FormaldehydeFormaldehyde results in decreased expression of TPK1 mRNA23649840
D019833GenisteinGenistein results in decreased expression of TPK1 mRNA23019147
D007213IndomethacinIndomethacin results in increased expression of TPK1 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TPK1 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TPK1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TPK1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TPK1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TPK1 mRNA"25620056
D009532NickelNickel results in increased expression of TPK1 mRNA24768652|2558310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TPK1 mRNA23978341
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TPK1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of TPK1 mRNA18301758|2381119
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TPK1 mRNA22714537
C009277sodium arsenatesodium arsenate results in increased expression of TPK1 mRNA23922661
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TPK1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPK1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TPK1 promoter]19654925
D019772TopotecanTPK1 protein affects the susceptibility to Topotecan16217747
C057693troglitazonetroglitazone results in increased expression of TPK1 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of TPK1 mRNA28001369
D014640VancomycinVancomycin results in increased expression of TPK1 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of TPK1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004788thiamine diphosphokinase activity-IBA21873635  
GO:0004788thiamine diphosphokinase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IEA-  
GO:0030975thiamine binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006772thiamine metabolic process-IEA-  
GO:0009229thiamine diphosphate biosynthetic process-IBA21873635  
GO:0009229thiamine diphosphate biosynthetic process-IEA-  
GO:0016310phosphorylation-IEA-  
GO:0042723thiamine-containing compound metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00730Thiamine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196819Vitamin B1 (thiamin) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal