Gene: CNTN6

27255
NB3
contactin 6
protein-coding
3p26.3
Ensembl:ENSG00000134115 MIM:607220 Vega:OTTHUMG00000119030 UniprotKB:Q9UQ52
NG_047144.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.773e-1 (AD)  3.342e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17038032chr3:1347433 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10510170chr3:1333292 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17036851chr3:1263731 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROBO20.862
EPHA50.861
CNTN40.85
SPHKAP0.846
RIMKLA0.845
TRIM360.844
ESRRG0.843
TMEM1690.842
ATP8A20.842
GPR610.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.607
ROM1-0.606
TGIF1-0.591
TRAF3IP2-0.589
IMPA2-0.581
STON2-0.577
TMEM176A-0.575
PXDC1-0.574
AGTRAP-0.574
FXYD3-0.572

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CNTN6 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CNTN6 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNTN6 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNTN6 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of CNTN6 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of CNTN6 mRNA25181051
D005419FlavonoidsFlavonoids results in increased expression of CNTN6 mRNA18035473
D008727MethotrexateMethotrexate affects the expression of CNTN6 mRNA18502557
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CNTN6 mRNA26272509
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of CNTN6 mRNA27029645
D012999SomanSoman results in decreased expression of CNTN6 mRNA19281266
D053260SootSoot results in decreased expression of CNTN6 mRNA26551751
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CNTN6 mRNA16979875
D014212TretinoinTretinoin results in decreased expression of CNTN6 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of CNTN6 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of CNTN6 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of CNTN6 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CNTN6 gene25560391
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CNTN6 mRNA16979875
D015034Zinc OxideZinc Oxide analog results in increased expression of CNTN6 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0007417central nervous system development-TAS9486763  
GO:0030182neuron differentiation-IEA-  
GO:0045747positive regulation of Notch signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-447041CHL1 interactionsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22205951Genome-wide association study in bipolar patients stratified by co-morbidity. (2011)Kerner BPLoS One