Gene: SULT1B1

27284
ST1B1|ST1B2|SULT1B2
sulfotransferase family 1B member 1
protein-coding
4q13.3
Ensembl:ENSG00000173597 MIM:608436 Vega:OTTHUMG00000129407 UniprotKB:O43704
NC_000004.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.799e-1 (AD)  2.142e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs77114337chr4:69758944 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MECOM0.789
CFI0.783
MPZL20.781
CARD60.778
HSPG20.774
MYOF0.77
C70.759
SHE0.759
CYYR10.755
ITGA10.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPATA2L-0.48
KCNIP3-0.472
ASPDH-0.461
FLRT1-0.442
RTN4R-0.441
BCL11A-0.438
PIP5KL1-0.437
RCOR2-0.436
CRH-0.433
MARCH4-0.431

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01812Adenosine-3'-5'-DiphosphateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0658331-hydroxymethylpyrene[SULT1B1 protein co-treated with PAPSS1 protein] results in increased activity of 1-hydroxymethylpyrene24802129
C0331461-hydroxypyreneSULT1B1 protein results in increased metabolism of 1-hydroxypyrene24140465
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SULT1B1 mRNA"20056577
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SULT1B1 mRNA"28433925
C0178212-amino-3-methyl-9H-pyrido(2,3-b)indole"SULT1B1 protein results in increased activity of 2-amino-3-methyl-9H-pyrido(2,3-b)indole"14729582
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SULT1B1 mRNA"19692669
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of SULT1B1 mRNA"24172598
C0248364-nitrophenolSULT1B1 protein results in increased metabolism of 4-nitrophenol10623578
C0415944-nonylphenolSULT1B1 protein results in increased metabolism of 4-nonylphenol10623578
C0804174-octylphenolSULT1B1 protein results in increased metabolism of 4-octylphenol10623578
D000082AcetaminophenAcetaminophen results in decreased expression of SULT1B1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SULT1B1 mRNA17562736
D000082Acetaminophen[Acetaminophen co-treated with Uranium analog] results in decreased expression of SULT1B1 mRNA17126469
D000082AcetaminophenAcetaminophen results in decreased expression of SULT1B1 mRNA17126469|1834677
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SULT1B1 mRNA22100608|2715375
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of SULT1B1 mRNA"23195993
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of SULT1B1 mRNA16940010
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SULT1B1 mRNA16483693
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of SULT1B1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of SULT1B1 mRNA23912714
D001151ArsenicArsenic results in increased methylation of SULT1B1 gene24525453
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SULT1B1 mRNA"25351596
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SULT1B1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SULT1B1 mRNA19770486
D019905Benzyl AlcoholSULT1B1 protein results in increased sulfation of Benzyl Alcohol26663444
C095105bexarotenebexarotene results in decreased expression of SULT1B1 mRNA16648578
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SULT1B1 mRNA26606162
C006780bisphenol Abisphenol A results in decreased expression of SULT1B1 mRNA24214726
C006780bisphenol ASULT1B1 protein results in increased metabolism of bisphenol A10623578
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SULT1B1 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of SULT1B1 mRNA25181051
C032036bromobenzenebromobenzene metabolite binds to SULT1B1 protein17305373
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SULT1B1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SULT1B1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SULT1B1 mRNA18346771
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of SULT1B1 mRNA27174168
D002713ChlorineChlorine results in decreased expression of SULT1B1 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of SULT1B1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SULT1B1 mRNA22659317
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SULT1B1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of SULT1B1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of SULT1B1 mRNA19320972
D003300CopperCopper deficiency results in decreased expression of SULT1B1 mRNA19821111
D003300CopperCopper results in decreased expression of SULT1B1 mRNA22465980
C030123coumarincoumarin affects the expression of SULT1B1 mRNA16963487
C029892cupric chloridecupric chloride results in decreased expression of SULT1B1 mRNA24650576
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SULT1B1 protein26984711
D016572CyclosporineCyclosporine results in decreased expression of SULT1B1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of SULT1B1 mRNA19770486
D003671DEET[fipronil co-treated with DEET] results in decreased expression of SULT1B1 mRNA27091632
D003907DexamethasoneDexamethasone results in increased expression of SULT1B1 mRNA26739637
D002945CisplatinCisplatin results in increased expression of SULT1B1 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SULT1B1 mRNA26924002
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SULT1B1 mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SULT1B1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1B1 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1B1 mRNA18544905
D004054DiethylstilbestrolSULT1B1 protein results in increased metabolism of Diethylstilbestrol10623578
D002117CalcitriolCalcitriol results in decreased expression of SULT1B1 mRNA27107558
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of SULT1B1 mRNA23876855
D004237DiuronDiuron metabolite results in increased expression of SULT1B1 mRNA24172598
D004997Ethinyl EstradiolSULT1B1 protein results in increased metabolism of Ethinyl Estradiol10623578
C024565ethylene dichlorideethylene dichloride results in decreased expression of SULT1B1 mRNA28189721
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of SULT1B1 mRNA27091632
C082360fipronilfipronil results in decreased expression of SULT1B1 mRNA27091632
C082360fipronilfipronil results in increased expression of SULT1B1 mRNA23962444
C082360fipronilfipronil results in increased expression of SULT1B1 mRNA22447239|2396244
C534368fipronil sulfonefipronil sulfone results in increased expression of SULT1B1 mRNA22447239
D005485FlutamideFlutamide results in decreased expression of SULT1B1 mRNA24793618
D005897GlafenineGlafenine results in decreased expression of SULT1B1 mRNA24136188
D005912GliotoxinGliotoxin results in decreased expression of SULT1B1 mRNA18346771
D007545IsoproterenolIsoproterenol results in decreased expression of SULT1B1 mRNA21335049
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1B1 mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1B1 mRNA18544905
D008012LidocaineSULT1B1 protein results in increased sulfation of Lidocaine metabolite10460806
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SULT1B1 mRNA"18346771
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1B1 mRNA"20371263
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SULT1B1 mRNA23876855
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SULT1B1 mRNA"25102311
C051752nefazodonenefazodone results in increased expression of SULT1B1 mRNA24136188
D009532NickelNickel results in decreased expression of SULT1B1 mRNA23195993
C022838nickel chloridenickel chloride affects the expression of SULT1B1 mRNA22110744
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of SULT1B1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of SULT1B1 protein19716841
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of SULT1B1 mRNA18636392
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SULT1B1 mRNA18978342
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SULT1B1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SULT1B1 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of SULT1B1 mRNA22258563
D010634PhenobarbitalPhenobarbital results in increased expression of SULT1B1 mRNA12807726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SULT1B1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SULT1B1 mRNA16221962|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SULT1B1 mRNA]20059764
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the metabolism of SULT1B1 protein21913674
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SULT1B1 mRNA19162173|2265931
C035988procymidoneprocymidone results in increased expression of SULT1B1 mRNA15686871
C031280pyrazolepyrazole results in decreased expression of SULT1B1 mRNA17945193
D011794QuercetinQuercetin affects the expression of SULT1B1 mRNA19270413
C052785rebamipiderebamipide results in increased expression of SULT1B1 mRNA18299717
C017947sodium arsenitesodium arsenite results in decreased expression of SULT1B1 mRNA20371982|2387685
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1B1 mRNA"20371263
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of SULT1B1 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT1B1 mRNA21296121
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SULT1B1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SULT1B1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SULT1B1 mRNA19692669|2121527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT1B1 mRNA22659317
D014212TretinoinTretinoin results in increased expression of SULT1B1 mRNA15977162
D014303TrinitrotolueneTrinitrotoluene affects the expression of SULT1B1 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SULT1B1 mRNA"25242413
D014415TunicamycinTunicamycin results in decreased expression of SULT1B1 mRNA17127020
C112106UAB 30UAB 30 analog results in increased expression of SULT1B1 mRNA23292798
D014501Uranium[Acetaminophen co-treated with Uranium analog] results in decreased expression of SULT1B1 mRNA17126469
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of SULT1B1 mRNA15885361
D014635Valproic AcidValproic Acid results in decreased expression of SULT1B1 mRNA29154799
C025643vinclozolinvinclozolin results in increased expression of SULT1B1 mRNA15686871
C029297vinylidene chloridevinylidene chloride results in increased expression of SULT1B1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004062aryl sulfotransferase activity-IDA23207770  
GO:0004062aryl sulfotransferase activity-TAS-  
GO:0005515protein binding-IPI21044950  25416956  25910212  
GO:0008146sulfotransferase activity-IDA9463486  19548878  20056724  
GO ID GO Term Qualifier Evidence PubMed
GO:0006068ethanol catabolic process-IDA23207770  
GO:0006576cellular biogenic amine metabolic process-TAS9443824  
GO:0006805xenobiotic metabolic process-IDA20056724  
GO:0008202steroid metabolic process-IEA-  
GO:0009812flavonoid metabolic process-IDA20056724  
GO:0018958phenol-containing compound metabolic process-IDA9463486  
GO:0030855epithelial cell differentiation-IEP21492153  
GO:0042403thyroid hormone metabolic process-IDA9443824  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-IDA23207770  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO:0051923sulfation-IDA19548878  20056724  23207770  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-NAS9463486  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26422515Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease. (2016 Jan)Janse ICInflamm Bowel Dis