Gene: RBMS3

27303
-
RNA binding motif single stranded interacting protein 3
protein-coding
3p24.1
Ensembl:ENSG00000144642 MIM:605786 Vega:OTTHUMG00000155699 UniprotKB:Q6XE24
NC_000003.12
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.518e-1 (AD)  4.756e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1438339chr3:29440555 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4130687chr3:29402620 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE5A0.801
EBF10.772
FAM111A0.771
KDELC20.769
ARHGAP290.757
CCDC500.757
SLC22A30.755
CNTLN0.75
SHE0.75
EPS80.749

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.465
MYADML2-0.433
GALNT14-0.424
FAM43B-0.416
ISLR2-0.414
GNB1L-0.407
HAS1-0.405
ASPDH-0.402
CHST8-0.401
SAC3D1-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RBMS3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RBMS3 mRNA29067470
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RBMS3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RBMS3 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RBMS3 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RBMS3 mRNA"19150397
D004958EstradiolEstradiol affects the expression of RBMS3 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of RBMS3 mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of RBMS3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RBMS3 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of RBMS3 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of RBMS3 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RBMS3 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of RBMS3 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RBMS3 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RBMS3 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of RBMS3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of RBMS3 mRNA20106945
D003907DexamethasoneDexamethasone results in decreased expression of RBMS3 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RBMS3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RBMS3 mRNA27392435
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of RBMS3 mRNA25242112
D004237DiuronDiuron results in decreased expression of RBMS3 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RBMS3 mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RBMS3 mRNA20938992
C001277geldanamycingeldanamycin results in increased expression of RBMS3 mRNA26705709
D017313FenretinideFenretinide results in decreased expression of RBMS3 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RBMS3 mRNA27392435
C042720mercuric bromidemercuric bromide results in increased expression of RBMS3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RBMS3 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of RBMS3 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RBMS3 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RBMS3 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RBMS3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RBMS3 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RBMS3 mRNA19812364
D009532NickelNickel results in decreased expression of RBMS3 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of RBMS3 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RBMS3 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RBMS3 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RBMS3 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of RBMS3 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of RBMS3 mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of RBMS3 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of RBMS3 mRNA24780913
D012834SilverSilver results in decreased expression of RBMS3 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of RBMS3 mRNA22714537
D013629TamoxifenTamoxifen affects the expression of RBMS3 mRNA17555576
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RBMS3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of RBMS3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of RBMS3 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RBMS3 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RBMS3 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of RBMS3 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RBMS3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of RBMS3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RBMS3 mRNA23179753|2438349
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBMS3 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of RBMS3 mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IBA21873635  
GO:0003730mRNA 3'-UTR binding-IBA21873635  
GO:0008143poly(A) binding-IBA21873635  
GO:0008143poly(A) binding-IDA10675610  
GO:0008266poly(U) RNA binding-IBA21873635  
GO:0008266poly(U) RNA binding-IDA10675610  
GO:0035925mRNA 3'-UTR AU-rich region binding-IDA10675610  
GO ID GO Term Qualifier Evidence PubMed
GO:0002357defense response to tumor cell-IMP28409548  
GO:0010628positive regulation of gene expression-IMP28409548  
GO:0010629negative regulation of gene expression-IMP28409548  
GO:0045727positive regulation of translation-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP28409548  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10675610  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal