Gene: TNRC6A

27327
CAGH26|GW1|GW182|TNRC6
trinucleotide repeat containing 6A
protein-coding
16p12.1
Ensembl:ENSG00000090905 MIM:610739 Vega:OTTHUMG00000096999 UniprotKB:Q8NDV7
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.537e-1 (AD)  3.893e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13336754chr16:24790658 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POGZ0.956
EP4000.936
TSC10.934
CCDC930.934
TTC170.925
CPSF70.921
RBM50.919
RBM330.919
EXOSC100.917
PNISR0.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.626
OR4F29-0.598
KLRC2-0.307
MTRNR2L9-0.244
CD8B-0.238
MDFI-0.228
TFPI2-0.227
KLRB1-0.223
XPNPEP2-0.221
MTRNR2L6-0.219

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TNRC6A mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TNRC6A mRNA]"27071940
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TNRC6A mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TNRC6A mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNRC6A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNRC6A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TNRC6A mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of TNRC6A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TNRC6A gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNRC6A mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of TNRC6A mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TNRC6A mRNA24449571
D001280AtrazineAtrazine results in increased expression of TNRC6A mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNRC6A mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNRC6A mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNRC6A mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of TNRC6A mRNA28159858
C006780bisphenol Abisphenol A affects the expression of TNRC6A mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TNRC6A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TNRC6A gene28505145
C584509C646 compoundC646 compound results in decreased expression of TNRC6A mRNA26191083
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TNRC6A mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TNRC6A mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNRC6A gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of TNRC6A mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of TNRC6A mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of TNRC6A mRNA19770486
D003561CytarabineCytarabine results in increased expression of TNRC6A mRNA21198554
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TNRC6A mRNA21266533
D005485FlutamideFlutamide results in increased expression of TNRC6A mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNRC6A gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of TNRC6A mRNA20655997
D005839GentamicinsGentamicins results in increased expression of TNRC6A mRNA22061828
D017313FenretinideFenretinide results in increased expression of TNRC6A mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of TNRC6A mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of TNRC6A mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNRC6A mRNA25613284
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of TNRC6A mRNA22839698
C045463leflunomideleflunomide results in decreased expression of TNRC6A mRNA28988120
D008345ManganeseManganese results in increased expression of TNRC6A mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of TNRC6A mRNA17175027
D008694MethamphetamineMethamphetamine results in increased expression of TNRC6A mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNRC6A gene20938992
D008727MethotrexateMethotrexate results in increased expression of TNRC6A mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNRC6A mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNRC6A mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of TNRC6A promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TNRC6A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNRC6A mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of TNRC6A mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TNRC6A mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of TNRC6A mRNA17175027
D010416PentachlorophenolPentachlorophenol results in increased expression of TNRC6A mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TNRC6A mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNRC6A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TNRC6A mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of TNRC6A mRNA18445702
C045950propiconazolepropiconazole results in decreased expression of TNRC6A mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of TNRC6A mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TNRC6A mRNA21427059
C541923sandostatinLARsandostatinLAR results in increased expression of TNRC6A mRNA17210224
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of TNRC6A mRNA17540011
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TNRC6A mRNA19073995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNRC6A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNRC6A mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNRC6A mRNA25613284
D014050TolueneToluene results in decreased expression of TNRC6A mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TNRC6A mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of TNRC6A mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of TNRC6A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TNRC6A mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of TNRC6A mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of TNRC6A mRNA19136453|2142705
C025643vinclozolinvinclozolin affects the expression of TNRC6A mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of TNRC6A mRNA20566332|2303416
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of TNRC6A mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI19167051  19324964  19383768  19716330  21063388  21840310  
21981923  22484317  23090477  24768540  25416956  26134560  
28877994  
GO ID GO Term Qualifier Evidence PubMed
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0035194posttranscriptional gene silencing by RNA-TAS-  
GO:0035195gene silencing by miRNA-IMP23172285  
GO:0035278miRNA mediated inhibition of translation-IDA17671087  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0060964regulation of gene silencing by miRNA-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IDA20616046  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-TAS-  
GO:0035068micro-ribonucleoprotein complex-IDA17671087  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-426496Post-transcriptional silencing by small RNAsTAS
R-HSA-5578749Transcriptional regulation by small RNAsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8943723Regulation of PTEN mRNA translationTAS
R-HSA-8948700Competing endogenous RNAs (ceRNAs) regulate PTEN translationTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal