Gene: UTP20

27340
1A6/DRIM|DRIM
UTP20, small subunit processome component
protein-coding
12q23.2
Ensembl:ENSG00000120800 MIM:612822 Vega:OTTHUMG00000170270 UniprotKB:O75691
NC_000012.12
PubMed|SNP Mapped
16   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.942e-1 (AD)  5.135e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7313312chr12:101361905 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11609516chr12:101361142 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10507130chr12:101360176 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs57083693chr12:101348402 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3782848chr12:101346082 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2270861chr12:101342603 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7977587chr12:101340906 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs56265469chr12:101338877 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1814577chr12:101335504 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7973083chr12:101330303 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs55721648chr12:101321424 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1472556chr12:101311400 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7296572chr12:101296439 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11608415chr12:101294267 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs844030chr12:101291644 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs703711chr12:101280507 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP2140.825
GEMIN50.818
ZFYVE260.817
SLC30A60.814
LRCH30.813
THADA0.812
SETX0.811
COG30.81
BIRC60.809
SETDB10.806

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.43
OR4F29-0.416
MUC7-0.232
KLRC2-0.194
OR4F16-0.194
SPINK2-0.192
SPRR3-0.184
PIP-0.176
LCN1-0.173
SPRR2A-0.171

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of UTP20 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of UTP20 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UTP20 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UTP20 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of UTP20 mRNA"26238291
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of UTP20 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UTP20 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of UTP20 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of UTP20 gene28505145
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of UTP20 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of UTP20 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of UTP20 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of UTP20 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of UTP20 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of UTP20 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UTP20 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of UTP20 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UTP20 mRNA27594783
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of UTP20 mRNA"22485181
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of UTP20 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of UTP20 intron27776689
D005485FlutamideFlutamide results in decreased expression of UTP20 mRNA24793618
D005485FlutamideFlutamide results in increased expression of UTP20 mRNA24136188
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of UTP20 gene28505145
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of UTP20 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of UTP20 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UTP20 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UTP20 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of UTP20 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of UTP20 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of UTP20 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of UTP20 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UTP20 mRNA25982114
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of UTP20 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UTP20 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UTP20 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of UTP20 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of UTP20 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of UTP20 protein23718831
D011441PropylthiouracilPropylthiouracil results in decreased expression of UTP20 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of UTP20 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of UTP20 mRNA21427059
C016104sodium bichromatesodium bichromate results in increased expression of UTP20 mRNA25993096
D014284Triiodothyronine[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UTP20 mRNA14761676
C061133tamibarotenetamibarotene results in decreased expression of UTP20 mRNA15498508
D013749Tetrachlorodibenzodioxin[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of UTP20 mRNA14761676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UTP20 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UTP20 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of UTP20 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of UTP20 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of UTP20 mRNA15498508
C012589trichostatin Atrichostatin A results in increased expression of UTP20 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of UTP20 mRNA19042947
D014520UrethaneUrethane results in decreased expression of UTP20 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of UTP20 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of UTP20 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of UTP20 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of UTP20 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UTP20 gene25560391
D014810Vitamin EVitamin E results in decreased expression of UTP20 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI16053918  17498821  
GO ID GO Term Qualifier Evidence PubMed
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-ISS15590835  
GO:0000472endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-ISS17652137  
GO:0000480endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)-ISS17652137  
GO:0006364rRNA processing-IMP17498821  
GO:0006364rRNA processing-TAS-  
GO:0008285negative regulation of cell proliferation-TAS9673349  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-ISS17652137  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA16458307  
GO:0005730nucleolus-ISS15590835  
GO:0005737cytoplasm-ISS17652137  
GO:0005886plasma membrane-IDA-  
GO:003068690S preribosome-IBA21873635  
GO:003068690S preribosome-ISS12150911  
GO:0030688preribosome, small subunit precursor-ISS17652137  
GO:0032040small-subunit processome-IBA21873635  
GO:0032040small-subunit processome-ISS15590835  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6790901rRNA modification in the nucleus and cytosolIEA
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingIEA
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNAIEA
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24962325Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. (2014 Sep 1)Kapoor MDrug Alcohol Depend