Gene info: ID 28234

Gene: SLCO1B3

GENE ID: 28234

Description: solute carrier organic anion transporter family member 1B3

Gene type: protein-coding

Location: 12p12.2

dbXrefs: Ensembl:ENSG00000111700 MIM:605495 Vega:OTTHUMG00000169011 UniprotKB:Q9NPD5

RefSeq: NG_032071.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.947e-1 (AD) 3.022e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10841707	chr12:20917203 (GRCh38.p7)	T>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4M2	0.769
OR51S1	0.745
OR51V1	0.739
OR4K14	0.733
OR12D3	0.732
OR2AP1	0.729
KRTAP9-1	0.727
OR5H1	0.726
SULT1C3	0.723
DEFB118	0.715

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C16orf95	-0.27
MYH7B	-0.264
HHATL	-0.247
ASPDH	-0.245
GPT	-0.24
SORCS2	-0.237
FAM43B	-0.234
TM7SF2	-0.227
ARIH2OS	-0.226
PAQR4	-0.226

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00175	Pravastatin	Small Molecule	81093-37-0	Approved	Transporter
DB00177	Valsartan	Small Molecule	137862-53-4	Approved\|Investigational	Transporter
DB00275	Olmesartan	Small Molecule	144689-24-7	Approved\|Investigational	Transporter
DB00279	Liothyronine	Small Molecule	6893-02-3	Approved	Transporter
DB00286	Conjugated estrogens	Small Molecule	12126-59-9	Approved	Transporter
DB00390	Digoxin	Small Molecule	20830-75-5	Approved	Transporter
DB00451	Levothyroxine	Small Molecule	51-48-9	Approved	Transporter
DB00520	Caspofungin	Small Molecule	162808-62-0	Approved	Transporter
DB00563	Methotrexate	Small Molecule	59-05-2	Approved	Transporter
DB00688	Mycophenolate mofetil	Small Molecule	128794-94-5	Approved\|Investigational	Transporter
DB00783	Estradiol	Small Molecule	50-28-2	Approved\|Investigational	Transporter
DB00950	Fexofenadine	Small Molecule	83799-24-0	Approved\|Investigational	Transporter
DB01045	Rifampicin	Small Molecule	13292-46-1	Approved	Transporter
DB01076	Atorvastatin	Small Molecule	134523-00-5	Approved	Transporter
DB01092	Ouabain	Small Molecule	630-60-4	Approved	Transporter
DB01095	Fluvastatin	Small Molecule	93957-54-1	Approved	Transporter
DB01098	Rosuvastatin	Small Molecule	287714-41-4	Approved	Transporter
DB01132	Pioglitazone	Small Molecule	111025-46-8	Approved\|Investigational	Transporter
DB01229	Paclitaxel	Small Molecule	33069-62-4	Approved	Transporter
DB01248	Docetaxel	Small Molecule	114977-28-5	Approved\|Investigational	Transporter
DB01583	Liotrix	Small Molecule	8065-29-0	Approved	Transporter
DB02659	Cholic Acid	Small Molecule	81-25-4	Approved	Transporter
DB02691	Glycocholic acid	Small Molecule	475-31-0	Experimental\|Investigational	Transporter
DB04348	Taurocholic Acid	Small Molecule	81-24-3	Experimental	Transporter
DB05239	Cobimetinib	Small Molecule	934660-93-2	Approved\|Investigational	Transporter
DB05804	Prasterone sulfate	Small Molecule	651-48-9	Investigational	Transporter
DB06176	Romidepsin	Small Molecule	128517-07-7	Approved\|Investigational	Transporter
DB06290	Simeprevir	Small Molecule	923604-59-5	Approved	Transporter
DB06403	Ambrisentan	Small Molecule	177036-94-1	Approved\|Investigational	Transporter
DB06772	Cabazitaxel	Small Molecule	183133-96-2	Approved	Transporter
DB08855	Leukotriene C4	Small Molecule	72025-60-6	Experimental\|Investigational	Transporter
DB08860	Pitavastatin	Small Molecule	147511-69-1	Approved	Transporter
DB08861	DPDPE	Small Molecule	88373-73-3	Experimental	Transporter
DB08862	Cholecystokinin	Small Molecule	9011-97-6	Approved\|Investigational	Transporter
DB08864	Rilpivirine	Small Molecule	500287-72-9	Approved	Transporter
DB08884	Gadoxetic acid	Small Molecule	135326-11-3	Approved	Transporter
DB08912	Dabrafenib	Small Molecule	-	Approved\|Investigational	Transporter
DB09054	Idelalisib	Small Molecule	870281-82-6	Approved	Transporter
DB09102	Daclatasvir	Small Molecule	1009119-64-5	Approved\|Investigational	Transporter
DB09137	Technetium Tc-99m mebrofenin	Small Molecule	1415247-71-0	Approved	Transporter
DB09292	Sacubitril	Small Molecule	149709-62-6	Approved	Transporter
DB11362	Selexipag	Small Molecule	475086-01-2	Approved	Transporter
DB11575	Grazoprevir	Small Molecule	1350514-68-9	Approved	Transporter
DB11613	Velpatasvir	Small Molecule	1377049-84-7	Approved\|Investigational	Transporter
DB11817	Baricitinib	Small Molecule	1187594-09-7	Approved\|Investigational	Transporter
DB12026	Voxilaprevir	Small Molecule	1535212-07-7	Approved\|Investigational	Transporter
DB12070	Letermovir	Small Molecule	917389-32-3	Approved\|Investigational	Transporter
DB12332	Rucaparib	Small Molecule	283173-50-2	Approved\|Investigational	Transporter
DB13139	Levosalbutamol	Small Molecule	34391-04-3	Approved\|Investigational	Transporter
DB13153	Levomenol	Small Molecule	23089-26-1	Approved\|Experimental	Transporter
DB13154	Parachlorophenol	Small Molecule	106-48-9	Approved	Transporter
DB13874	Enasidenib	Small Molecule	1446502-11-9	Approved\|Investigational	Transporter
DB13878	Pibrentasvir	Small Molecule	1353900-92-1	Approved\|Investigational	Transporter
DB13879	Glecaprevir	Small Molecule	1365970-03-1	Approved\|Investigational	Transporter
DB13928	Semaglutide	Small Molecule	910463-68-2	Approved\|Investigational	Transporter
DB13952	Estradiol acetate	Small Molecule	4245-41-4	Approved\|Investigational	Transporter
DB13953	Estradiol benzoate	Small Molecule	50-50-0	Approved\|Investigational	Transporter
DB13954	Estradiol cypionate	Small Molecule	313-06-4	Approved\|Investigational	Transporter
DB13955	Estradiol dienanthate	Small Molecule	7732-97-0	Approved\|Investigational	Transporter
DB13956	Estradiol valerate	Small Molecule	979-32-8	Approved\|Investigational	Transporter
DB01045	Rifampicin	Small Molecule	13292-46-1	Approved	Target
DB01211	Clarithromycin	Small Molecule	81103-11-9	Approved	Target
DB06749	ginsenoside Rb1	Small Molecule	41753-43-9	Nutraceutical	Target
DB06750	Ginsenoside Rg1	Small Molecule	22427-39-0	Nutraceutical	Target
DB05016	Ataluren	Small Molecule	775304-57-9	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C555859	2,2',4,4',5,6'-hexabromodiphenyl ether	"2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]"	20176623
C555859	2,2',4,4',5,6'-hexabromodiphenyl ether	"SLCO1B3 results in increased import of 2,2',4,4',5,6'-hexabromodiphenyl ether"	20176623
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]"	20176623
C511295	2,2',4,4'-tetrabromodiphenyl ether	"SLCO1B3 results in increased import of 2,2',4,4'-tetrabromodiphenyl ether"	20176623
C561635	(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid	SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid	21661758
C561635	(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]	21661758
C000588958	5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid	5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid results in decreased activity of SLCO1B3 protein	23631744
C090019	8-sulfocholecystokinin octapeptide	rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]	27450509
C090019	8-sulfocholecystokinin octapeptide	SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide	27450509
C090019	8-sulfocholecystokinin octapeptide	Tobacco Smoke Pollution inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]	27450509
D020106	Acrylamide	Acrylamide results in decreased expression of SLCO1B3 mRNA	28959563
D000242	Cyclic AMP	SLCO1B3 protein results in increased uptake of Cyclic AMP analog	25542188
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SLCO1B3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SLCO1B3 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SLCO1B3 gene	27153756
D019804	Mesalamine	Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D019804	Mesalamine	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D019804	Mesalamine	Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D019804	Mesalamine	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D019804	Mesalamine	SLCO1B3 protein results in increased uptake of Mesalamine	21430235
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLCO1B3 mRNA	16483693
D047310	Apigenin	Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D001151	Arsenic	Arsenic affects the methylation of SLCO1B3 gene	25304211
D000069059	Atorvastatin Calcium	glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D000069059	Atorvastatin Calcium	Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D000069059	Atorvastatin Calcium	nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D000069059	Atorvastatin Calcium	repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D000069059	Atorvastatin Calcium	rosiglitazone inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D000069059	Atorvastatin Calcium	SLCO1B3 protein results in increased uptake of Atorvastatin Calcium	23121773\|2510641
D000069059	Atorvastatin Calcium	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	25106415
D001647	Bile Acids and Salts	SLCO1B3 protein affects the transport of Bile Acids and Salts	15841457
D001647	Bile Acids and Salts	SLCO1B3 protein affects the uptake of Bile Acids and Salts	15841457
D001647	Bile Acids and Salts	TAK-875 inhibits the reaction [SLCO1B3 protein results in increased transport of Bile Acids and Salts]	28108665
D001647	Bile Acids and Salts	Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]	19464309
D001647	Bile Acids and Salts	Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of Taurocholic Acid]	19464309
C006780	bisphenol A	bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
C006780	bisphenol A	bisphenol A results in decreased expression of SLCO1B3 mRNA	25181051
C000611646	bisphenol F	bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
D019819	Budesonide	Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D019819	Budesonide	Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D002220	Carbamazepine	Carbamazepine results in increased expression of SLCO1B3 mRNA	17112801
D012844	Sincalide	SLCO1B3 protein results in increased transport of Sincalide	20079461
D012844	Sincalide	[icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide	24265111
D012844	Sincalide	SLCO1B3 protein affects the import of Sincalide	16046661
D012844	Sincalide	SLCO1B3 protein affects the uptake of Sincalide	15665139
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of SLCO1B3 mRNA	25055961\|2717416
D002635	Chenodeoxycholic Acid	SLCO1B3 protein results in increased transport of Chenodeoxycholic Acid	18648741
D002635	Chenodeoxycholic Acid	[SLCO1B3 protein results in increased transport of Chenodeoxycholic Acid] which results in increased expression of PTGS2 mRNA	18648741
D019826	Cholic Acid	Cholic Acid results in increased expression of SLCO1B3 mRNA	25055961
D019826	Cholic Acid	SLCO1B3 protein results in increased uptake of Cholic Acid	16534140
D017291	Clarithromycin	Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SLCO1B3 mRNA	19376846
C057862	cyanoginosin LR	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]	17369605
C057862	cyanoginosin LR	Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]	26134461
C057862	cyanoginosin LR	Okadaic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of cyanoginosin LR]	26134461
C057862	cyanoginosin LR	Rifampin inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]	17369605
C057862	cyanoginosin LR	SLCO1B3 protein results in increased import of cyanoginosin LR	17369605
C057862	cyanoginosin LR	SLCO1B3 protein results in increased susceptibility to cyanoginosin LR	17369605\|2017123
C057862	cyanoginosin LR	SLCO1B3 protein results in increased uptake of cyanoginosin LR	25456266\|2613446
C057862	cyanoginosin LR	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]	17369605
C057862	cyanoginosin LR	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]	20171238\|2613446
C057862	cyanoginosin LR	Taurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]	26134461
D016572	Cyclosporine	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]	17369605
D016572	Cyclosporine	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]	18180276
D016572	Cyclosporine	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D016572	Cyclosporine	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D019314	Dehydroepiandrosterone Sulfate	Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]	26134461
D019314	Dehydroepiandrosterone Sulfate	Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]	26134461
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of SLCO1B3 mRNA	25055961
D003840	Deoxycholic Acid	SLCO1B3 protein results in increased transport of Deoxycholic Acid	18648741
D003840	Deoxycholic Acid	[SLCO1B3 protein results in increased transport of Deoxycholic Acid] which results in increased expression of PTGS2 mRNA	18648741
D003840	Deoxycholic Acid	SLCO1B3 protein results in increased uptake of Deoxycholic Acid	16534140
D003907	Dexamethasone	Dexamethasone results in decreased expression of SLCO1B3 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of SLCO1B3 mRNA]	20032058
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SLCO1B3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SLCO1B3 mRNA	27392435
D002117	Calcitriol	Calcitriol results in increased expression of SLCO1B3 mRNA	16002434
C025483	estradiol-17 beta-glucuronide	SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide	20079461
C025483	estradiol-17 beta-glucuronide	"2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]"	20176623
C025483	estradiol-17 beta-glucuronide	"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]"	20176623
C025483	estradiol-17 beta-glucuronide	pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]	20176623
C025483	estradiol-17 beta-glucuronide	[SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide	18180276
C025483	estradiol-17 beta-glucuronide	SLCO1B3 results in increased import of estradiol-17 beta-glucuronide	20176623
C025483	estradiol-17 beta-glucuronide	Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]	19464309
C025483	estradiol-17 beta-glucuronide	SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide	19464309
C017296	estrone sulfate	SLCO1B3 protein results in increased transport of estrone sulfate	20079461
C093230	fexofenadine	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]	18180276
C093230	fexofenadine	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]	18180276
C093230	fexofenadine	[SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadine	18180276
C093230	fexofenadine	SLCO1B3 protein results in increased uptake of fexofenadine	18245269
D019793	Fluorescein	bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
D019793	Fluorescein	bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
D019793	Fluorescein	Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
D019793	Fluorescein	SLCO1B3 protein results in increased uptake of Fluorescein	27989701
D019793	Fluorescein	tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
D005485	Flutamide	Flutamide results in decreased expression of SLCO1B3 mRNA	24793618
C065180	fluvastatin	SLCO1B3 protein affects the import of fluvastatin	16046661
C069837	fullerene C60	fullerene C60 affects the expression of SLCO1B3 mRNA	19167457
C039281	furan	furan results in decreased expression of SLCO1B3 mRNA	25539665\|2619464
D005672	Fusidic Acid	Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]	26888941
D005672	Fusidic Acid	Fusidic Acid results in decreased activity of SLCO1B3 protein	27676153
C442759	ginsenoside Rb1	ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein	25297453
C044462	ginsenoside Rc	ginsenoside Rc binds to and results in decreased activity of SLCO1B3 protein	25297453
C049863	ginsenoside Rd	ginsenoside Rd binds to and results in decreased activity of SLCO1B3 protein	25297453
C049864	ginsenoside Re	SLCO1B3 protein binds to and results in increased transport of ginsenoside Re	25297453
C035054	ginsenoside Rg1	SLCO1B3 protein binds to and results in increased transport of ginsenoside Rg1	25297453
C057619	glimepiride	glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
C057619	glimepiride	glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	23121773
D005905	Glyburide	Glyburide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D006918	Hydroxyurea	naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]	21256917
D006918	Hydroxyurea	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]	21256917
D006918	Hydroxyurea	SLCO1B3 protein results in increased uptake of Hydroxyurea	21256917
C056599	icariin	icariin results in decreased activity of SLCO1B3 protein	24265111
C056599	icariin	[icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide	24265111
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SLCO1B3 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of SLCO1B3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SLCO1B3 mRNA	26752646
C006552	kaempferol	kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLCO1B3 mRNA"	18930950
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of SLCO1B3 mRNA	25055961
D008095	Lithocholic Acid	SLCO1B3 protein results in increased transport of Lithocholic Acid	18648741
D008095	Lithocholic Acid	[SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA	18648741
D008095	Lithocholic Acid	SLCO1B3 protein results in increased uptake of Lithocholic Acid	16534140
C078588	microcystin	SLCO1B3 protein results in increased susceptibility to microcystin analog	20171238
C524165	microcystin-LF	SLCO1B3 protein results in increased susceptibility to microcystin-LF	20171238
D052998	Microcystins	SLCO1B3 protein results in increased uptake of Microcystins	20472527
C005273	naringenin	naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
C005274	naringin	naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
C005274	naringin	naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]	21256917
C060142	nateglinide	nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
C060142	nateglinide	nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	23121773
C028007	nickel monoxide	nickel monoxide affects the expression of SLCO1B3 mRNA	19167457
C072936	notoginsenoside R1	SLCO1B3 protein binds to and results in increased transport of notoginsenoside R1	25297453
C464660	obeticholic acid	obeticholic acid results in increased expression of SLCO1B3 mRNA	27939613
D019319	Okadaic Acid	Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]	26134461
D019319	Okadaic Acid	Okadaic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of cyanoginosin LR]	26134461
D019319	Okadaic Acid	SLCO1B3 protein results in increased susceptibility to Okadaic Acid	26134461
D019319	Okadaic Acid	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]	26134461
D019319	Okadaic Acid	Taurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]	26134461
C026209	oltipraz	oltipraz results in decreased expression of SLCO1B3 mRNA	16837569
D052638	Particulate Matter	Particulate Matter results in decreased activity of SLCO1B3 protein	25803276
D052638	Particulate Matter	Particulate Matter results in decreased expression of SLCO1B3 mRNA	25803276
D020881	Enkephalin, D-Penicillamine (2,5)-	"SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)-"	20079461
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]	20176623
C086401	pentabromodiphenyl ether	SLCO1B3 results in increased import of pentabromodiphenyl ether	20176623
C539348	perfluorobutanesulfonic acid	SLCO1B3 protein results in increased transport of perfluorobutanesulfonic acid	28013215
C471071	perfluorohexanesulfonic acid	SLCO1B3 protein results in increased transport of perfluorohexanesulfonic acid	28013215
C076994	perfluorooctane sulfonic acid	SLCO1B3 protein results in increased transport of perfluorooctane sulfonic acid	28013215
D010590	Phalloidine	SLCO1B3 protein results in increased uptake of Phalloidine	19464309\|2528077
D010634	Phenobarbital	Phenobarbital results in decreased expression of SLCO1B3 mRNA	16837569
C060836	pioglitazone	pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	23121773
D017035	Pravastatin	Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D017035	Pravastatin	Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D011339	Probenecid	Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of SLCO1B3 mRNA	26100227
D011794	Quercetin	Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D011794	Quercetin	SLCO1B3 protein results in increased uptake of Quercetin	24947867
C072379	repaglinide	repaglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D012293	Rifampin	Rifampin inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]	17369605
D012293	Rifampin	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]	18180276
D012293	Rifampin	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]	21256917
D012293	Rifampin	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]	21430235
D012293	Rifampin	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D012293	Rifampin	Rifampin results in decreased expression of SLCO1B3 mRNA	27199754
C023808	rifamycin SV	rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]	27450509
C089730	rosiglitazone	rosiglitazone inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	23121773
D000068718	Rosuvastatin Calcium	Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]	26888941
D000068718	Rosuvastatin Calcium	SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium	26888941
D012431	Rutin	Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
C009237	senecionine	senecionine results in decreased expression of SLCO1B3 mRNA	26100227
D013448	Sulfobromophthalein	SLCO1B3 protein results in increased transport of Sulfobromophthalein	20079461
D013448	Sulfobromophthalein	Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D013448	Sulfobromophthalein	Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D013448	Sulfobromophthalein	Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D013448	Sulfobromophthalein	Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D013448	Sulfobromophthalein	glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	23121773
D013448	Sulfobromophthalein	kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D013448	Sulfobromophthalein	naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D013448	Sulfobromophthalein	naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D013448	Sulfobromophthalein	nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	23121773
D013448	Sulfobromophthalein	pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	23121773
D013448	Sulfobromophthalein	Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D013448	Sulfobromophthalein	Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D013448	Sulfobromophthalein	Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]	21430235
D013448	Sulfobromophthalein	Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]	22394605
D013448	Sulfobromophthalein	SLCO1B3 protein affects the import of Sulfobromophthalein	16046661
D013448	Sulfobromophthalein	SLCO1B3 protein results in increased import of Sulfobromophthalein	22394605
D013448	Sulfobromophthalein	SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein	20171238
D013448	Sulfobromophthalein	SLCO1B3 protein results in increased uptake of Sulfobromophthalein	21430235\|2312177
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]	17369605
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]	20171238\|2613446
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]	26134461
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]	21661758
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin Calcium]	25106415
D013448	Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]	25106415
C557331	TAK-875	TAK-875 inhibits the reaction [SLCO1B3 protein results in increased transport of Bile Acids and Salts]	28108665
C557331	TAK-875	TAK-875 results in decreased activity of SLCO1B3 protein	28108665
D013656	Taurocholic Acid	SLCO1B3 protein results in increased transport of Taurocholic Acid	20079461
D013656	Taurocholic Acid	SLCO1B3 protein results in increased uptake of Taurocholic Acid	19464309
D013656	Taurocholic Acid	Taurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]	26134461
D013656	Taurocholic Acid	Taurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]	26134461
D013656	Taurocholic Acid	Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of Taurocholic Acid]	19464309
D013656	Taurocholic Acid	SLCO1B3 protein results in increased uptake of Taurocholic Acid	19464309
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of SLCO1B3 mRNA]	20032058
C020806	tetrabromobisphenol A	tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]	27989701
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased activity of SLCO1B3 protein	27989701
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLCO1B3 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLCO1B3 mRNA	16837569
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SLCO1B3 mRNA	21215274
D013853	Thioacetamide	Thioacetamide results in decreased expression of SLCO1B3 mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]	27450509
C003330	trospium chloride	trospium chloride results in decreased activity of SLCO1B3 protein	25466967
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLCO1B3 mRNA"	18930950
D014580	Ursodeoxycholic Acid	SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid	16534140
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of SLCO1B3 mRNA	15885361
D014635	Valproic Acid	Valproic Acid results in decreased expression of SLCO1B3 mRNA	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased activity of SLCO1B3 protein	25803276
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of SLCO1B3 mRNA	25803276

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008514	organic anion transmembrane transporter activity	-	TAS	10779507
GO:0015125	bile acid transmembrane transporter activity	-	IBA	21873635
GO:0015125	bile acid transmembrane transporter activity	-	TAS	-
GO:0015347	sodium-independent organic anion transmembrane transporter activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0015711	organic anion transport	-	TAS	10779507
GO:0015721	bile acid and bile salt transport	-	IBA	21873635
GO:0015721	bile acid and bile salt transport	-	TAS	-
GO:0043252	sodium-independent organic anion transport	-	IBA	21873635
GO:0043252	sodium-independent organic anion transport	-	TAS	-
GO:0055085	transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	10779507
GO:0016323	basolateral plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04976	Bile secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-159418	Recycling of bile acids and salts	TAS
R-HSA-1643685	Disease	TAS
R-HSA-194068	Bile acid and bile salt metabolism	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	TAS
R-HSA-425407	SLC-mediated transmembrane transport	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	TAS
R-HSA-5619102	SLC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-879518	Transport of organic anions	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23462698	Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver. (2013 May)	More VR	Drug Metab Dispos
23371916	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. (2013 Apr)	Dai X	Genet Epidemiol