Gene: ADGRD1

283383
GPR133|PGR25
adhesion G protein-coupled receptor D1
protein-coding
12q24.33
Ensembl:ENSG00000111452 MIM:613639 Vega:OTTHUMG00000168339 UniprotKB:Q6QNK2
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.488e-1 (AD)  6.662e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4759814chr12:130970676 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06730GestodeneSmall Molecule60282-87-3Approved|InvestigationalTarget
DB12637OnapristoneSmall Molecule96346-61-1InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of ADGRD1 mRNA"25270620
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of ADGRD1 mRNA"26377693
C496492abrineabrine results in decreased expression of ADGRD1 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of ADGRD1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of ADGRD1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADGRD1 mRNA27153756
D000638AmiodaroneAmiodarone results in increased expression of ADGRD1 mRNA19774075
D001151ArsenicArsenic affects the methylation of ADGRD1 gene25304211
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ADGRD1 mRNA20660070
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADGRD1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ADGRD1 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of ADGRD1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ADGRD1 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of ADGRD1 mRNA26079696
C031180chrysenechrysene results in increased expression of ADGRD1 mRNA26377693
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ADGRD1 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of ADGRD1 mRNA25562108|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADGRD1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADGRD1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of ADGRD1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ADGRD1 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ADGRD1 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of ADGRD1 mRNA]21852083
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ADGRD1 mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADGRD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADGRD1 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of ADGRD1 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADGRD1 mRNA26644586
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ADGRD1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADGRD1 mRNA"25554681
D009532NickelNickel results in increased expression of ADGRD1 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ADGRD1 mRNA20971185
D000073878Palm OilPalm Oil results in decreased expression of ADGRD1 mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of ADGRD1 mRNA17426115
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ADGRD1 mRNA20660070
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of ADGRD1 mRNA]21852083
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADGRD1 mRNA25895662
D012834SilverSilver affects the expression of ADGRD1 mRNA27131904
C032910triadimefontriadimefon results in decreased expression of ADGRD1 mRNA26705709
C012589trichostatin Atrichostatin A results in increased expression of ADGRD1 mRNA26705709
D014520UrethaneUrethane results in decreased expression of ADGRD1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ADGRD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ADGRD1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of ADGRD1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IBA21873635  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IDA22025619  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IDA22025619  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA22025619  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IDA22025619  25533341  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal