Gene: ARL10

285598
ARL10A
ADP ribosylation factor like GTPase 10
protein-coding
5q35.2
Ensembl:ENSG00000175414 Vega:OTTHUMG00000130655 UniprotKB:Q8N8L6
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.594e-1 (AD)  6.515e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13170785chr5:176368663 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHLPP20.923
RALGPS10.916
HECTD40.915
C16orf700.914
RALGAPB0.912
ARHGEF70.91
CAMSAP10.908
BTRC0.907
RPAP20.907
ZC3H12B0.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.443
OR4F5-0.434
CSAG1-0.433
HEY2-0.422
S100A1-0.41
MYL3-0.409
ASB4-0.402
OR4F29-0.391
ENDOU-0.388
RAB13-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ARL10 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARL10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARL10 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ARL10 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ARL10 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ARL10 mRNA"19446018
C006780bisphenol Abisphenol A results in decreased expression of ARL10 mRNA25181051
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARL10 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ARL10 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of ARL10 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARL10 gene20938992
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ARL10 mRNA15467011
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ARL10 mRNA23640034
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARL10 gene20938992
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of ARL10 gene21212295
D008713MethimazoleMethimazole results in decreased expression of ARL10 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARL10 gene20938992
C029938nickel sulfatenickel sulfate results in decreased expression of ARL10 mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of ARL10 mRNA25596134
C006253pirinixic acidpirinixic acid results in decreased expression of ARL10 mRNA17950772
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARL10 mRNA22504374
D011441PropylthiouracilPropylthiouracil results in increased expression of ARL10 mRNA24780913
C017947sodium arsenitesodium arsenite results in decreased expression of ARL10 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARL10 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of ARL10 gene21212295
D013853ThioacetamideThioacetamide results in increased expression of ARL10 mRNA23411599
D014635Valproic AcidValproic Acid results in increased expression of ARL10 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ARL10 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal