Gene: MICU3

286097
EFHA2
mitochondrial calcium uptake family member 3
protein-coding
8p22
Ensembl:ENSG00000155970 MIM:610633 Vega:OTTHUMG00000096965 UniprotKB:Q86XE3
NC_000008.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.397e-1 (AD)  5.770e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10090288chr8:17072126 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17624782chr8:17058471 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCAMP10.946
LMBRD20.942
ANKRD460.939
CSRNP30.939
NAP1L20.937
TRUB10.937
GLRB0.936
SLC2A130.935
KIF3A0.935
BAG40.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.592
MTRNR2L10-0.5
CNN2-0.486
KCNJ15-0.484
RNF135-0.48
MAGEA12-0.48
OR4F5-0.475
NFE2-0.465
MTRNR2L8-0.463
RUNX3-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of MICU3 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MICU3 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MICU3 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MICU3 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MICU3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MICU3 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MICU3 mRNA19770486
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MICU3 protein]26598702
C547126AZM551248AZM551248 results in decreased expression of MICU3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MICU3 mRNA21632981
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of MICU3 mRNA26496021
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MICU3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MICU3 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of MICU3 mRNA26496021
D002104CadmiumCadmium results in decreased expression of MICU3 mRNA24067728
D016572CyclosporineCyclosporine results in decreased expression of MICU3 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MICU3 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of MICU3 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MICU3 mRNA22079256
D004397FonofosFonofos results in increased methylation of MICU3 promoter22847954
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MICU3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MICU3 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of MICU3 mRNA27392435
C045463leflunomideleflunomide results in increased expression of MICU3 mRNA28988120
D009532NickelNickel results in decreased expression of MICU3 mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in increased methylation of MICU3 gene26431795
D010278ParathionParathion results in increased methylation of MICU3 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MICU3 mRNA27153767
C018637phoronephorone affects the expression of MICU3 mRNA18198479
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MICU3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MICU3 mRNA22079256
C012568terbufosterbufos results in increased methylation of MICU3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MICU3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MICU3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MICU3 mRNA24680724
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MICU3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of MICU3 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of MICU3 mRNA24935251
D014520UrethaneUrethane results in decreased expression of MICU3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of MICU3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MICU3 mRNA24935251

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006851mitochondrial calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005743mitochondrial inner membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-8949215Mitochondrial calcium ion transportTAS
R-HSA-8949664Processing of SMDT1TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal