Gene: GRK5

2869
GPRK5
G protein-coupled receptor kinase 5
protein-coding
10q26.11
Ensembl:ENSG00000198873 MIM:600870 Vega:OTTHUMG00000019149 UniprotKB:P34947
NC_000010.11
PubMed|SNP Mapped
3   ANCO-SNPs
OD|CD|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.346e-1 (AD)  3.117e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2297641chr10:119452893 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1316543chr10:119445148 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7095989chr10:119265585 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00522048chr10:121172431GRK53.250e-8Maternal smoking in pregnancy27040690
cg14351425chr10:120968739GRK55.010e-8Maternal smoking in pregnancy27040690
cg24539517chr10:121161258GRK51.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C11orf950.792
RAPGEF10.768
AFAP10.766
FKBP1A0.764
SRF0.762
ST3GAL20.756
NPAS20.749
DAB2IP0.747
PPP6R10.743
ERGIC10.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.605
OR4F29-0.569
CTNNA3-0.374
ZFP57-0.365
MYOT-0.363
RHBDL2-0.355
FXYD4-0.338
POU2AF1-0.333
BTBD16-0.317
PDE11A-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in decreased expression of GRK5 mRNA"19784758
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GRK5 mRNA19933214
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GRK5 mRNA"23196670
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of GRK5 mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRK5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRK5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GRK5 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GRK5 mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of GRK5 mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of GRK5 mRNA19784758
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GRK5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GRK5 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRK5 mRNA16483693
D001151ArsenicArsenic affects the methylation of GRK5 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of GRK5 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRK5 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRK5 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRK5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GRK5 mRNA"19150397|2623829
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GRK5 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of GRK5 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRK5 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of GRK5 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of GRK5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GRK5 mRNA28628672
C037123cadmium sulfatecadmium sulfate results in increased expression of GRK5 mRNA21783983
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GRK5 mRNA19784758
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GRK5 mRNA16644059
C043211carvedilolGRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]24334028
C043211carvedilolGRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]24334028
C043211carvedilolGRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]24334028
C043211carvedilolGRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]24334028
C043211carvedilolGRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]24334028
C000602816CCG215022CCG215022 binds to and results in decreased activity of GRK5 protein26032411
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRK5 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of GRK5 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of GRK5 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of GRK5 mRNA15755911
D003471CuprizoneCuprizone results in increased expression of GRK5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of GRK5 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of GRK5 mRNA19770486
D003561CytarabineCytarabine results in increased expression of GRK5 mRNA19194470
D003907DexamethasoneDexamethasone results in increased expression of GRK5 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GRK5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRK5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GRK5 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of GRK5 mRNA19561079
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GRK5 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of GRK5 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of GRK5 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GRK5 mRNA21592394
D004237DiuronDiuron results in increased expression of GRK5 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of GRK5 mRNA25896364
D004837EpinephrineEpinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]14722251
C082360fipronilfipronil results in increased expression of GRK5 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRK5 mRNA20938992
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in increased expression of GRK5 mRNA20664735
D017313FenretinideFenretinide results in decreased expression of GRK5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GRK5 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of GRK5 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GRK5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRK5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GRK5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of GRK5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GRK5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GRK5 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of GRK5 mRNA20003209
C008261lead acetatelead acetate results in increased expression of GRK5 mRNA11578147
C045463leflunomideleflunomide results in increased expression of GRK5 mRNA28988120
D008558MelphalanMelphalan results in decreased expression of GRK5 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GRK5 mRNA20938992
C008493methylselenic acidmethylselenic acid results in increased expression of GRK5 mRNA18548127
D008790MetoprololGRK5 protein affects the susceptibility to Metoprolol22888001
D008790MetoprololGRK5 protein affects the reaction [Metoprolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]]22888001
D009020MorphineMorphine results in increased expression of GRK5 mRNA15183518
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GRK5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GRK5 mRNA"25554681
D009578NitrobenzenesNitrobenzenes analog results in decreased expression of GRK5 mRNA19784758
C015405ophiocordinophiocordin results in decreased activity of GRK5 protein26032411
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GRK5 mRNA25729387
D010126OzoneOzone results in decreased expression of GRK5 mRNA16330353
C016030pantogabpantogab results in decreased expression of GRK5 mRNA17379144
D017374ParoxetineParoxetine results in decreased activity of GRK5 protein26032411
D010634PhenobarbitalPhenobarbital affects the expression of GRK5 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GRK5 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of GRK5 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of GRK5 mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in increased expression of GRK5 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of GRK5 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRK5 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GRK5 mRNA16985257
D010936Plant ExtractsPlant Extracts results in increased expression of GRK5 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GRK5 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRK5 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GRK5 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of GRK5 mRNA19059307
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of GRK5 mRNA21427059
C078903seocalcitolseocalcitol results in increased expression of GRK5 mRNA12040012
D013629TamoxifenTamoxifen affects the expression of GRK5 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of GRK5 mRNA19059307
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GRK5 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of GRK5 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GRK5 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRK5 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRK5 mRNA19770486|1993321
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of GRK5 mRNA28973375
D013853ThioacetamideThioacetamide results in decreased expression of GRK5 mRNA19784758
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GRK5 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GRK5 mRNA19448997|2897337
C012589trichostatin Atrichostatin A results in increased expression of GRK5 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GRK5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GRK5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRK5 mRNA19101580
D014635Valproic AcidValproic Acid results in increased expression of GRK5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of GRK5 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GRK5 gene25560391
D002762CholecalciferolCholecalciferol results in increased expression of GRK5 mRNA16508948
D024483Vitamin K 3Vitamin K 3 affects the expression of GRK5 mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of GRK5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IDA20124405  
GO:0004703G-protein coupled receptor kinase activity-IEA-  
GO:0005080protein kinase C binding-TAS9813065  
GO:0005515protein binding-IPI17986524  19008357  19661922  20124405  
GO:0005524ATP binding-IEA-  
GO:0005543phospholipid binding-TAS9813065  
GO:0047696beta-adrenergic receptor kinase activity-IMP20038610  
GO:0047696beta-adrenergic receptor kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-TAS8626574  
GO:0007217tachykinin receptor signaling pathway-IDA17986524  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS8288567  
GO:0008284positive regulation of cell proliferation-IMP22099983  
GO:0016055Wnt signaling pathway-IEA-  
GO:0043066negative regulation of apoptotic process-IDA20124405  
GO:0045444fat cell differentiation-IEA-  
GO:0046777protein autophosphorylation-IDA14976207  
GO:0051726regulation of cell cycle-IMP22099983  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS7685906  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA14976207  17986524  
GO:0005886plasma membrane-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsIEA
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24629717Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5. (2014 Nov 15)Gluck LBiol Psychiatry
25213649Cocaine potentiates multiple 5-HT2A receptor signaling pathways and is associated with decreased phosphorylation of 5-HT2A receptors in vivo. (2015 Mar)Franklin JMJ Mol Neurosci
28990359Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. (2017 Dec)Polimanti RAm J Med Genet B Neuropsychiatr Genet