Gene: GRID1

2894
GluD1
glutamate ionotropic receptor delta type subunit 1
protein-coding
10q23.1-q23.2
Ensembl:ENSG00000182771 MIM:610659 Vega:OTTHUMG00000018650 UniprotKB:Q9ULK0
NG_011875.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.956e-1 (AD)  4.144e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1806590chr10:86086042 (GRCh38.p7)A>G / A>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03420998chr10:88124936GRID1Gene body2.548e-4Alcohol use disorders26763658
cg08529931chr10:88124564GRID1Gene body6.375e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCAM10.916
FAM171A10.912
ATG130.908
VPS110.903
MPP20.9
GNAO10.898
TM9SF40.895
CORO2B0.895
PTPRS0.893
DGCR20.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.585
TFPI2-0.431
SIX1-0.41
CLEC2B-0.392
MTRNR2L6-0.39
TNFAIP8-0.39
MTRNR2L9-0.387
PABPC4L-0.381
ELF5-0.379

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of GRID1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GRID1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GRID1 mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GRID1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GRID1 mRNA24449571
D034341Aristolochic AcidsAristolochic Acids results in decreased expression of GRID1 mRNA21834575
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRID1 mRNA22316170
C006780bisphenol Abisphenol A affects the expression of GRID1 mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of GRID1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRID1 gene28505145
D004390ChlorpyrifosChlorpyrifos affects the expression of GRID1 mRNA17452286
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GRID1 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of GRID1 mRNA18353800
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of GRID1 mRNA]21095227
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GRID1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GRID1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GRID1 mRNA27392435
D004026DieldrinDieldrin affects the expression of GRID1 mRNA19440498
D000431EthanolEthanol results in increased expression of GRID1 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of GRID1 mRNA]"20655511
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GRID1 mRNA20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GRID1 mRNA27392435
D007854LeadLead affects the expression of GRID1 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GRID1 mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GRID1 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRID1 mRNA"20188158
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of GRID1 mRNA]"20655511
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GRID1 mRNA25895662
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of GRID1 mRNA]21095227
C017947sodium arsenitesodium arsenite affects the methylation of GRID1 gene28589171
D014212TretinoinTretinoin results in decreased expression of GRID1 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of GRID1 mRNA16604517
D014635Valproic AcidValproic Acid results in increased expression of GRID1 mRNA28001369
D024483Vitamin K 3Vitamin K 3 affects the expression of GRID1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004970ionotropic glutamate receptor activity-IEA-  
GO:0005234extracellularly glutamate-gated ion channel activity-IEA-  
GO:0008066glutamate receptor activity-IBA21873635  
GO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0034220ion transmembrane transport-IEA-  
GO:0035176social behavior-ISS-  
GO:0035235ionotropic glutamate receptor signaling pathway-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0050804modulation of chemical synaptic transmission-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0098839postsynaptic density membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22064162Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (2012 Feb)Edwards ACPsychiatr Genet
26683835Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. (2015 Dec 18)Ahmad SBMC Med Genet
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp