Gene info: ID 2905

Gene: GRIN2C

GENE ID: 2905

Synonyms: GluN2C|NMDAR2C|NR2C

Description: glutamate ionotropic receptor NMDA type subunit 2C

Gene type: protein-coding

Location: 17q25.1

dbXrefs: Ensembl:ENSG00000161509 MIM:138254 Vega:OTTHUMG00000044524 UniprotKB:Q14957

RefSeq: NC_000017.11

Retrived from: PubMed|SNP Mapped

SNPs: 6 ANCO-SNPs

Phenotype: AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.145e-2 (AD) 8.500e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs690371	chr17:74862956 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs2683267	chr17:74858860 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs690578	chr17:74857308 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs690533	chr17:74854034 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs11652088	chr17:74843693 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs9901283	chr17:74841693 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg23119809	chr17:72839750	GRIN2C	Gene body	1.805e-5	Alcohol use disorders	26763658
cg12536809	chr17:72852514	GRIN2C	Promoter	5.314e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MLC1	0.907
GPR37L1	0.905
FGFR3	0.902
BMP7	0.899
SLC7A10	0.892
ACSS1	0.886
CLDN10	0.883
SLC1A2	0.882
PSD2	0.876
ACSBG1	0.875

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EMB	-0.451
TDRD1	-0.429
SYNPO2	-0.419
CCDC68	-0.416
CD163L1	-0.408
DKK2	-0.407
PLA2G4A	-0.402
NOX4	-0.394
CPXM2	-0.393
TNFRSF19	-0.392

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00145	Glycine	Small Molecule	56-40-6	Approved\|Nutraceutical	Target
DB00454	Pethidine	Small Molecule	57-42-1	Approved	Target
DB01520	Tenocyclidine	Small Molecule	21500-98-1	Experimental\|Illicit\|Investigational	Target
DB00659	Acamprosate	Small Molecule	77337-76-9	Approved\|Investigational	Target
DB06741	Gavestinel	Small Molecule	153436-22-7	Investigational	Target
DB09409	Magnesium acetate tetrahydrate	Small Molecule	16674-78-5	Approved	Target
DB09481	Magnesium carbonate	Small Molecule	546-93-0	Approved\|Investigational	Target
DB13146	Fluciclovine (18F)	Small Molecule	222727-39-1	Approved	Target
DB00289	Atomoxetine	Small Molecule	83015-26-3	Approved	Target
DB00312	Pentobarbital	Small Molecule	76-74-4	Approved\|Investigational	Target
DB00418	Secobarbital	Small Molecule	76-73-3	Approved	Target
DB00996	Gabapentin	Small Molecule	60142-96-3	Approved\|Investigational	Target
DB01174	Phenobarbital	Small Molecule	50-06-6	Approved\|Investigational	Target
DB01708	Prasterone	Small Molecule	53-43-0	Approved\|Investigational\|Nutraceutical	Target
DB04896	Milnacipran	Small Molecule	92623-85-3	Approved\|Investigational	Target
DB06738	Ketobemidone	Small Molecule	469-79-4	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2C mRNA"	25510870
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of GRIN2C protein"	20297801
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIN2C mRNA"	22467012
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of GRIN2C mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of GRIN2C mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2C mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2C mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2C mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2C mRNA"	25510870
C491996	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	"(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid analog binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]"	14718249
C491996	(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid	"(2S,3R)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]"	14718249
C050592	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]	14718249
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of GRIN2C mRNA"	21346803
C498554	5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	"5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]"	14718249
D000082	Acetaminophen	Acetaminophen results in increased expression of GRIN2C mRNA	23824016
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GRIN2C mRNA	21641981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GRIN2C mRNA	22545673
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GRIN2C mRNA	23630614
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GRIN2C mRNA	23630614
D000376	Agmatine	Agmatine results in decreased activity of [GRIN2C protein binds to GRIN1 protein]	15982768
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of GRIN2C mRNA	21298039
D015074	2-Aminoadipic Acid	2-Aminoadipic Acid binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]	14718249
D000643	Ammonium Chloride	GRIN2C protein affects the susceptibility to Ammonium Chloride	12971910
D000643	Ammonium Chloride	traxoprodil mesylate promotes the reaction [GRIN2C protein affects the susceptibility to Ammonium Chloride]	12971910
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GRIN2C mRNA	16483693
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of GRIN2C mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GRIN2C mRNA	21569818
C095105	bexarotene	bexarotene results in increased expression of GRIN2C mRNA	17630414
C006780	bisphenol A	bisphenol A results in decreased methylation of GRIN2C promoter	27312807
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA	25607892
C006780	bisphenol A	bisphenol A results in decreased expression of GRIN2C mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GRIN2C mRNA	12414654
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA	25607892
D000068579	Celecoxib	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]	21589914
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN2C gene	20938992
D002994	Clofibrate	Clofibrate results in increased expression of GRIN2C mRNA	22008526
D003024	Clozapine	Clozapine results in decreased expression of GRIN2C mRNA	18923069
D003042	Cocaine	Cocaine affects the expression of GRIN2C mRNA	20187946
C055407	conotoxin GV	conotoxin GV results in decreased activity of [GRIN1A protein co-treated with GRIN2C protein]	21396956
D003471	Cuprizone	Cuprizone results in decreased expression of GRIN2C mRNA	26577399\|2752363
D003976	Diazinon	Diazinon results in increased expression of GRIN2C mRNA	17452286\|1944049
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of GRIN2C mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of GRIN2C mRNA	27392435
D004026	Dieldrin	Dieldrin affects the expression of GRIN2C mRNA	19440498
D016291	Dizocilpine Maleate	Dizocilpine Maleate results in decreased expression of GRIN2C mRNA	11169168
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA	25607892
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of GRIN2C mRNA	21277884
D000431	Ethanol	Ethanol results in decreased expression of GRIN2C mRNA	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GRIN2C mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2C mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GRIN2C mRNA	23649840
D018690	Excitatory Amino Acid Agonists	Excitatory Amino Acid Agonists results in increased expression of GRIN2C mRNA	28987794
C047360	felbamate	felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]	10690753
C047360	felbamate	felbamate results in decreased activity of [GRIN1 protein binds to GRIN2C protein]	10215667
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN2C gene	20938992
D004397	Fonofos	Fonofos results in increased methylation of GRIN2C promoter	22847954
D005839	Gentamicins	Gentamicins results in increased expression of GRIN2C protein	15200423
D006220	Haloperidol	Haloperidol results in increased expression of GRIN2C mRNA	15860345
C089796	hexabromocyclododecane	hexabromocyclododecane affects the expression of GRIN2C mRNA	24680724
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GRIN2C mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GRIN2C mRNA	12414654
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of GRIN2C mRNA	21396975
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GRIN2C mRNA	23824016
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of GRIN2C mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of GRIN2C mRNA	27392435
D007608	Kainic Acid	Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]	21589914
D007608	Kainic Acid	Kainic Acid results in decreased expression of GRIN2C mRNA	21589914
D007608	Kainic Acid	PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]	21589914
D007649	Ketamine	Ketamine results in increased expression of GRIN2C mRNA	20080153
C008261	lead acetate	lead acetate results in increased expression of GRIN2C mRNA	24260418
C017461	lead nitrate	lead nitrate results in increased expression of GRIN2C mRNA	23358146
D008558	Melphalan	Melphalan results in increased expression of GRIN2C mRNA	22363485
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIN2C gene	20938992
D008727	Methotrexate	Methotrexate results in increased expression of GRIN2C mRNA	21678067
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GRIN2C mRNA	19409459
D008911	Minocycline	Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA]	19660546
D009020	Morphine	Morphine results in increased expression of GRIN2C mRNA	15183518
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GRIN2C mRNA"	25554681
D009284	Naphthols	Naphthols metabolite results in decreased activity of [GRIN1 protein binds to GRIN2C protein]	20858708
D009532	Nickel	Nickel results in decreased expression of GRIN2C mRNA	19440498
C028007	nickel monoxide	nickel monoxide results in increased expression of GRIN2C mRNA	19167457
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of GRIN2C mRNA	25607892
D010069	Oxadiazoles	Oxadiazoles metabolite results in increased activity of [GRIN1 protein binds to GRIN2C protein]	20858708
D010269	Paraquat	Paraquat results in increased expression of GRIN2C mRNA	18198484
D010278	Parathion	Parathion results in increased methylation of GRIN2C promoter	22847954
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRIN2C mRNA"	25510870
C410127	PCB 180	PCB 180 results in decreased expression of GRIN2C protein	20297801
D010424	Pentobarbital	Pentobarbital affects the expression of GRIN2C mRNA	9814547
D010616	Phenanthrenes	Phenanthrenes binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]	14718249
D010616	Phenanthrenes	Phenanthrenes metabolite results in decreased activity of [GRIN1 protein binds to GRIN2C protein]	20858708
D010616	Phenanthrenes	Phenanthrenes metabolite results in increased activity of [GRIN1 protein binds to GRIN2C protein]	20858708
D010634	Phenobarbital	Phenobarbital results in increased expression of GRIN2C mRNA	22008526
D010879	Piperazines	Piperazines metabolite binds to and results in decreased activity of GRIN2C protein	19684252
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of GRIN2C mRNA	22008526\|2248451
D010936	Plant Extracts	Plant Extracts results in decreased expression of GRIN2C mRNA	23557933
D011066	Poly C	Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA]	19660546
D011066	Poly C	Poly C results in increased expression of GRIN2C mRNA	19660546
C005556	propionaldehyde	propionaldehyde results in increased expression of GRIN2C mRNA	26079696
C065286	SDZ EAA 494	SDZ EAA 494 binds to and results in decreased activity of [GRIN2C protein binds to GRIN1 protein]	14718249
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GRIN2C mRNA	25895662
C012568	terbufos	terbufos results in increased methylation of GRIN2C promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GRIN2C mRNA	24680724
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2C mRNA	17942748
C095106	traxoprodil mesylate	traxoprodil mesylate promotes the reaction [GRIN2C protein affects the susceptibility to Ammonium Chloride]	12971910
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of GRIN2C mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GRIN2C mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of GRIN2C mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased methylation of GRIN2C gene	29154799
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of GRIN2C mRNA	12414654

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004972	NMDA glutamate receptor activity	-	IBA	21873635
GO:0004972	NMDA glutamate receptor activity	-	IDA	26919761
GO:0004972	NMDA glutamate receptor activity	-	TAS	17526495
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005234	extracellularly glutamate-gated ion channel activity	-	IEA	-
GO:0005515	protein binding	-	IPI	11937501
GO:0022849	glutamate-gated calcium ion channel activity	-	IDA	26875626

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0007215	glutamate receptor signaling pathway	-	TAS	9798920
GO:0007420	brain development	-	NAS	17526495
GO:0009611	response to wounding	-	IEA	-
GO:0019722	calcium-mediated signaling	-	IEA	-
GO:0033058	directional locomotion	-	IEA	-
GO:0035235	ionotropic glutamate receptor signaling pathway	-	IEA	-
GO:0042177	negative regulation of protein catabolic process	-	IEA	-
GO:0048167	regulation of synaptic plasticity	-	NAS	17526495
GO:0050885	neuromuscular process controlling balance	-	IEA	-
GO:0060079	excitatory postsynaptic potential	-	IBA	21873635
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0060291	long-term synaptic potentiation	-	IBA	21873635
GO:0097553	calcium ion transmembrane import into cytosol	-	IDA	26875626
GO:0098976	excitatory chemical synaptic transmission	-	NAS	17526495
GO:1903539	protein localization to postsynaptic membrane	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	IEA	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	26875626 26919761
GO:0017146	NMDA selective glutamate receptor complex	-	IBA	21873635
GO:0017146	NMDA selective glutamate receptor complex	-	IDA	26875626 26919761
GO:0017146	NMDA selective glutamate receptor complex	-	TAS	17526495
GO:0030054	cell junction	-	IEA	-
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098839	postsynaptic density membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04720	Long-term potentiation
hsa05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	TAS
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6794361	Neurexins and neuroligins	IEA
R-HSA-6794362	Protein-protein interactions at synapses	TAS
R-HSA-6794362	Protein-protein interactions at synapses	IEA
R-HSA-8849932	Synaptic adhesion-like molecules	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26289945	The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. (2015 Nov)	Bach P	Addict Biol
18444252	Neurotransmission and bipolar disorder: a systematic family-based association study. (2008 Oct 5)	Shi J	Am J Med Genet B Neuropsychiatr Genet
25655461	Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)	Manzardo AM	Gene