Gene: ZBTB44

29068
BTBD15|HSPC063|ZNF851
zinc finger and BTB domain containing 44
protein-coding
11q24.3
Ensembl:ENSG00000196323 Vega:OTTHUMG00000165769 UniprotKB:Q8NCP5
NC_000011.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.129e-1 (AD)  5.681e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7933236chr11:130241833 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAN1A20.871
ZZZ30.87
ZNF7040.866
PCMTD20.865
CREBRF0.864
TAOK10.861
WDFY30.86
RMND5A0.858
SPAST0.858
ZNF1480.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.575
OR4F5-0.571
S100A14-0.335
PDZK1IP1-0.302
AHSP-0.287
PRRX2-0.287
CDC42EP5-0.281
PITX3-0.279
C6orf223-0.269
CSAG1-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ZBTB44 mRNA"20453058
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ZBTB44 mRNA"15215175
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ZBTB44 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZBTB44 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB44 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZBTB44 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB44 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ZBTB44 mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZBTB44 mRNA24449571
D001151ArsenicArsenic affects the methylation of ZBTB44 gene25304211
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZBTB44 mRNA"19150397
C018475butyraldehydebutyraldehyde results in decreased expression of ZBTB44 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in increased expression of ZBTB44 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of ZBTB44 mRNA25562108
D003703DemecolcineDemecolcine results in decreased expression of ZBTB44 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZBTB44 mRNA21266533
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ZBTB44 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of ZBTB44 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ZBTB44 mRNA19467301
D004237DiuronDiuron results in increased expression of ZBTB44 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ZBTB44 mRNA"23811387
C024565ethylene dichlorideethylene dichloride results in decreased expression of ZBTB44 mRNA28189721
C039281furanfuran results in increased methylation of ZBTB44 gene22079235
D007213IndomethacinIndomethacin results in decreased expression of ZBTB44 mRNA16984733
D007545IsoproterenolIsoproterenol results in increased expression of ZBTB44 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of ZBTB44 mRNA27392435
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA22563483
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZBTB44 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ZBTB44 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ZBTB44 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of ZBTB44 mRNA23811387
D010100OxygenOxygen deficiency results in increased expression of ZBTB44 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of ZBTB44 mRNA]22629407
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA22563483
D010269ParaquatParaquat results in increased expression of ZBTB44 mRNA22563483
D010615PhenacetinPhenacetin results in decreased expression of ZBTB44 mRNA17082564
D010634PhenobarbitalPhenobarbital affects the expression of ZBTB44 mRNA23091169
C030299phenylhydrazinephenylhydrazine results in decreased expression of ZBTB44 mRNA17082564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZBTB44 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ZBTB44 mRNA26272509
C049032pinosylvinpinosylvin results in decreased expression of ZBTB44 mRNA23333577
C006253pirinixic acidpirinixic acid results in increased expression of ZBTB44 mRNA18301758|2381119
C045950propiconazolepropiconazole results in decreased expression of ZBTB44 mRNA21278054
C428725pyridabenpyridaben results in increased expression of ZBTB44 mRNA22563483
D012643SeleniumSelenium results in decreased expression of ZBTB44 mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of ZBTB44 gene28589171
D018038Sodium SeleniteSodium Selenite results in increased expression of ZBTB44 mRNA24383545
C057693troglitazonetroglitazone results in decreased expression of ZBTB44 mRNA28973697
D014520UrethaneUrethane results in increased expression of ZBTB44 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB44 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZBTB44 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZBTB44 mRNA23179753|2627250
D014638VanadatesVanadates results in decreased expression of ZBTB44 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ZBTB44 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal