Gene info: ID 29969

Gene: MDFIC

GENE ID: 29969

Synonyms: HIC|MDFIC1

Description: MyoD family inhibitor domain containing

Gene type: protein-coding

Location: 7q31.1-q31.2

dbXrefs: Ensembl:ENSG00000135272 MIM:614511 Vega:OTTHUMG00000023647 UniprotKB:Q9P1T7

RefSeq: NG_029463.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.971e-1 (AD) 8.248e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs13237006	chr7:115018432 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg26275647	chr7:114648973	MDFIC	Gene body	5.544e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEDD1	0.835
PGGT1B	0.832
CPNE3	0.827
BNIP2	0.811
TWSG1	0.805
RAP1B	0.804
CMTM6	0.796
FERMT2	0.795
ATL3	0.795
SMAD5	0.794

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FBLN7	-0.506
ADRA1D	-0.495
RTP1	-0.474
BHLHA9	-0.473
HAS1	-0.472
PIP5KL1	-0.468
CDH22	-0.459
FADS6	-0.455
MYOZ3	-0.454
NKX6-3	-0.454

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of MDFIC mRNA"	19162173
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of MDFIC mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MDFIC protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MDFIC gene	27153756
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MDFIC mRNA	19770486\|2171566
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MDFIC mRNA	22228805\|2719552
D004958	Estradiol	Estradiol affects the expression of MDFIC mRNA	14699072\|2257421
D004958	Estradiol	Estradiol promotes the reaction [ESR2 protein affects the expression of MDFIC mRNA]	20404318
D004958	Estradiol	Estradiol results in increased expression of MDFIC mRNA	25210133
C006780	bisphenol A	bisphenol A results in increased expression of MDFIC mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of MDFIC mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of MDFIC mRNA	26079696
D002220	Carbamazepine	Carbamazepine affects the expression of MDFIC mRNA	25979313
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDFIC mRNA	20938992
D003471	Cuprizone	Cuprizone results in increased expression of MDFIC mRNA	26577399\|2752363
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of MDFIC mRNA	17403535
D013759	Dronabinol	Dronabinol results in increased expression of MDFIC mRNA	16616335
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MDFIC mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of MDFIC mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of MDFIC mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in decreased expression of MDFIC mRNA	25016146
D002117	Calcitriol	Calcitriol results in increased expression of MDFIC mRNA	16002434
D005047	Etoposide	MDFIC protein affects the susceptibility to Etoposide	16217747
D005472	Fluorouracil	Fluorouracil affects the expression of MDFIC mRNA	16584549
D005485	Flutamide	Flutamide results in decreased expression of MDFIC mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDFIC mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of MDFIC mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of MDFIC mRNA	19167457
C001277	geldanamycin	geldanamycin results in increased expression of MDFIC mRNA	26705709
D017313	Fenretinide	Fenretinide results in decreased expression of MDFIC mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MDFIC mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of MDFIC mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MDFIC mRNA	24796395
C008261	lead acetate	lead acetate results in decreased expression of MDFIC mRNA	22641619
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDFIC mRNA	20938992
C029938	nickel sulfate	nickel sulfate results in decreased expression of MDFIC mRNA	22714537
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of MDFIC mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of MDFIC mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of MDFIC mRNA	26272509
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MDFIC mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of MDFIC mRNA	18301758\|2005976
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of MDFIC mRNA]	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of MDFIC mRNA	19162173
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of MDFIC mRNA	27029645
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of MDFIC mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA	19059307
C059514	resveratrol	resveratrol results in decreased expression of MDFIC mRNA	25905778
D012999	Soman	Soman results in increased expression of MDFIC mRNA	19281266
D013629	Tamoxifen	Tamoxifen affects the expression of MDFIC mRNA	14699072
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA	19059307
D013629	Tamoxifen	Tamoxifen results in increased expression of MDFIC mRNA	25123088
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MDFIC mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MDFIC mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MDFIC mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of MDFIC mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of MDFIC mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of MDFIC mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of MDFIC gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of MDFIC mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MDFIC mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MDFIC gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of MDFIC mRNA	23179753\|2493525
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MDFIC gene	25560391
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDFIC mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of MDFIC mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	12192039 17289077
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0008134	transcription factor binding	-	IPI	12192039
GO:0030332	cyclin binding	-	IPI	12944466
GO:0030957	Tat protein binding	-	IDA	12944466 16260749

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007257	activation of JUN kinase activity	-	IDA	12192039
GO:0016032	viral process	-	IEA	-
GO:0030111	regulation of Wnt signaling pathway	-	IDA	12192039
GO:0042308	negative regulation of protein import into nucleus	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IBA	21873635
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	12944466
GO:0050434	positive regulation of viral transcription	-	IBA	21873635
GO:0050434	positive regulation of viral transcription	-	IDA	10671520

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal