Gene: OBP2A

29991
LCN13|OBP|OBP2C|OBPIIa|hOBPIIa
odorant binding protein 2A
protein-coding
9q34.3
Ensembl:ENSG00000122136 MIM:164320 Vega:OTTHUMG00000020909 UniprotKB:Q9NY56
NG_029693.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  6.995e-1 (ND)   (Frontal_Cortex)
7.807e-1 (AD)  5.852e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7045084chr9:135545890 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRG20.626
GSDMC0.443
KRTAP13-20.433
OBP2B0.427
USP17L80.416
TSPAN120.401
HSD17B60.393
OR52N50.391
TNNT10.39
KCNJ140.37

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAT-0.291
AP1G2-0.287
MAGEC3-0.27
PLGLB1-0.267
LENG8-0.266
GSDMB-0.264
ZWINT-0.261
FTCD-0.261
LRP2BP-0.259
ANKRD65-0.259

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of OBP2A mRNA"26377693
C05440011-(dansylamino)undecanoic acid11-(dansylamino)undecanoic acid binds to OBP2A protein16461020
C0271321-anilino-8-naphthalenesulfonate1-anilino-8-naphthalenesulfonate binds to OBP2A protein16461020
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OBP2A mRNA]18700144
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OBP2A mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of OBP2A mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of OBP2A mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of OBP2A mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of OBP2A mRNA24763279
C093628cyproconazolecyproconazole results in decreased expression of OBP2A mRNA22334560|2397080
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of OBP2A mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of OBP2A mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of OBP2A mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of OBP2A mRNA24535843
C109476epoxiconazoleepoxiconazole results in decreased expression of OBP2A mRNA22334560|2397080
D004397FonofosFonofos results in increased methylation of OBP2A promoter22847954
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of OBP2A mRNA24763279
C000625835HFPO2 compoundHFPO2 compound results in decreased expression of OBP2A mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in decreased expression of OBP2A mRNA27553808
D009532NickelNickel results in decreased expression of OBP2A mRNA25583101
D000073878Palm OilPalm Oil affects the expression of OBP2A mRNA19680557
D010278ParathionParathion results in increased methylation of OBP2A promoter22847954
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of OBP2A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of OBP2A mRNA19270015|1948288
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of OBP2A mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of OBP2A mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of OBP2A mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of OBP2A mRNA22334560|2397080
C446685systhanesysthane results in decreased expression of OBP2A mRNA23970803
C013698tallowtallow affects the expression of OBP2A mRNA19680557
D013629TamoxifenTamoxifen results in increased expression of OBP2A mRNA25123088
C012568terbufosterbufos results in increased methylation of OBP2A promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OBP2A mRNA28922406
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of OBP2A mRNA28973375
D014212TretinoinTretinoin binds to OBP2A protein16461020
C032910triadimefontriadimefon results in decreased expression of OBP2A mRNA23970803
D014241TrichloroethyleneTrichloroethylene results in decreased expression of OBP2A mRNA25549359
D014635Valproic AcidValproic Acid results in increased methylation of OBP2A gene29154799
D014635Valproic AcidValproic Acid affects the expression of OBP2A mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005549odorant binding-NAS10607840  
GO:0036094small molecule binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007606sensory perception of chemical stimulus-TAS10607840  
GO:0007608sensory perception of smell-IEA-  
GO:0050896response to stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal