Gene info: ID 3092

Gene: HIP1

GENE ID: 3092

Synonyms: HIP-I|ILWEQ|SHON|SHONbeta|SHONgamma

Description: huntingtin interacting protein 1

Gene type: protein-coding

Location: 7q11.23

dbXrefs: Ensembl:ENSG00000127946 MIM:601767 Vega:OTTHUMG00000156050 UniprotKB:O00291

RefSeq: NG_023251.2

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.906e-1 (AD) 5.289e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs237238	chr7:75582098 (GRCh38.p7)	A>C / A>G / A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs237240	chr7:75581343 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CERS2	0.864
RDX	0.861
USP54	0.861
MTUS1	0.86
TCF12	0.857
VEZF1	0.849
KIF13B	0.847
PHLDB1	0.847
DOCK5	0.844
NDE1	0.838

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FBLN7	-0.43
PNOC	-0.421
PRTN3	-0.418
KLK5	-0.41
PCDH8	-0.404
CRH	-0.4
DLX5	-0.397
KCNK3	-0.39
BHLHA9	-0.39
TAC3	-0.387

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIP1 mRNA"	27188386
C029370	4-toluidine	4-toluidine results in decreased expression of HIP1 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIP1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of HIP1 mRNA	21420995
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of HIP1 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HIP1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of HIP1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of HIP1 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of HIP1 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of HIP1 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HIP1 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HIP1 mRNA	20106945\|2623829
D004958	Estradiol	Estradiol results in decreased expression of HIP1 mRNA	25210133
D001622	Betaine	Betaine results in decreased expression of HIP1 mRNA	26391144
C006780	bisphenol A	bisphenol A affects the expression of HIP1 mRNA	25181051
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HIP1 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of HIP1 mRNA	19549813
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of HIP1 mRNA	23640034
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HIP1 mRNA	21266533
C000944	dicrotophos	dicrotophos results in increased expression of HIP1 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of HIP1 mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of HIP1 mRNA	26924002
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIP1 mRNA	22079256
D000431	Ethanol	Ethanol results in increased expression of HIP1 mRNA	28986285
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HIP1 mRNA	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HIP1 mRNA	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HIP1 mRNA	17942748
D017313	Fenretinide	Fenretinide results in decreased expression of HIP1 mRNA	28973697
D007213	Indomethacin	Indomethacin results in decreased expression of HIP1 mRNA	28201806
C011890	kojic acid	kojic acid results in increased expression of HIP1 mRNA	16595896
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HIP1 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HIP1 mRNA	26378955
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of HIP1 mRNA	26924002
D009151	Mustard Gas	Mustard Gas affects the expression of HIP1 mRNA	15651846
C022838	nickel chloride	nickel chloride affects the expression of HIP1 mRNA	22110744\|2254681
C029938	nickel sulfate	nickel sulfate results in increased expression of HIP1 mRNA	16780908
D010705	Phosgene	Phosgene affects the expression of HIP1 mRNA	16300373
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIP1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of HIP1 mRNA	22079256
D015474	Isotretinoin	Isotretinoin results in increased expression of HIP1 mRNA	20436886
C541923	sandostatinLAR	sandostatinLAR results in decreased expression of HIP1 mRNA	17210224
C009250	sevoflurane	sevoflurane results in decreased expression of HIP1 mRNA	26206149
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of HIP1 mRNA	25895662
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HIP1 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HIP1 mRNA	26378955
D013629	Tamoxifen	Tamoxifen results in increased expression of HIP1 mRNA	15590111
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of HIP1 mRNA	20189893
C020806	tetrabromobisphenol A	tetrabromobisphenol A affects the expression of HIP1 mRNA	18976794
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HIP1 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HIP1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HIP1 gene]	20819909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HIP1 mRNA	15328365\|1580003
D013849	Thimerosal	Thimerosal results in decreased expression of HIP1 mRNA	27188386
D014212	Tretinoin	Tretinoin results in decreased expression of HIP1 mRNA	21934132\|2372400
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIP1 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of HIP1 mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of HIP1 mRNA	24935251\|2627250
D014520	Urethane	Urethane results in decreased expression of HIP1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of HIP1 mRNA	28001369
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HIP1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of HIP1 mRNA	19015723

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005154	epidermal growth factor receptor binding	-	TAS	20074057
GO:0005200	structural constituent of cytoskeleton	-	TAS	9140394
GO:0005515	protein binding	-	IPI	9140394 11517213 11788820 11889126 15383276 16027218 16979168 17500595 17762867 22835334 25241761 25416956 26496610
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	NOT	IDA	14732715
GO:0030276	clathrin binding	-	IBA	21873635
GO:0030276	clathrin binding	-	IDA	11577110 14732715
GO:0032051	clathrin light chain binding	-	IBA	21873635
GO:0032051	clathrin light chain binding	-	IPI	15533940 18790740
GO:0032266	phosphatidylinositol-3-phosphate binding	-	IDA	14732715
GO:0035091	phosphatidylinositol binding	-	IBA	21873635
GO:0035091	phosphatidylinositol binding	-	IDA	14732715
GO:0035254	glutamate receptor binding	-	TAS	20074057
GO:0035612	AP-2 adaptor complex binding	-	IPI	15533940
GO:0035615	clathrin adaptor activity	-	IBA	21873635
GO:0035615	clathrin adaptor activity	-	IC	18790740
GO:0042803	protein homodimerization activity	-	IDA	15533940 18790740
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	-	IBA	21873635
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	-	IDA	14732715
GO:0046982	protein heterodimerization activity	-	IPI	15533940
GO:0051015	actin filament binding	-	IBA	21873635
GO:0051015	actin filament binding	-	IDA	18790740
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	-	IBA	21873635
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	-	IDA	14732715

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IEA	-
GO:0006915	apoptotic process	-	IDA	11788820
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IBA	21873635
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	11788820
GO:0007010	cytoskeleton organization	-	IEA	-
GO:0007015	actin filament organization	-	IBA	21873635
GO:0030100	regulation of endocytosis	-	NAS	20074057
GO:0030154	cell differentiation	-	IEA	-
GO:0042981	regulation of apoptotic process	-	IDA	11788820
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	-	IMP	14732715
GO:0048260	positive regulation of receptor-mediated endocytosis	-	IBA	21873635
GO:0048260	positive regulation of receptor-mediated endocytosis	-	IMP	11532990 11577110
GO:0048268	clathrin coat assembly	-	IBA	21873635
GO:0048268	clathrin coat assembly	-	IDA	11577110 11889126
GO:0050821	protein stabilization	-	IDA	14732715
GO:0051897	positive regulation of protein kinase B signaling	-	IC	14732715
GO:0061024	membrane organization	-	TAS	-
GO:0072583	clathrin-dependent endocytosis	-	IEA	-
GO:0097190	apoptotic signaling pathway	-	IDA	11007801
GO:0099637	neurotransmitter receptor transport	-	TAS	20074057
GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway	-	IMP	14732715

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	TAS	20074057
GO:0005737	cytoplasm	COLOCALIZES_WITH	IBA	21873635
GO:0005737	cytoplasm	-	IDA	11604514
GO:0005794	Golgi apparatus	-	IDA	11788820
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	TAS	9147654
GO:0016020	membrane	-	TAS	9147654
GO:0030122	AP-2 adaptor complex	COLOCALIZES_WITH	IBA	21873635
GO:0030122	AP-2 adaptor complex	colocalizes_with	IDA	14732715
GO:0030136	clathrin-coated vesicle	COLOCALIZES_WITH	IBA	21873635
GO:0030136	clathrin-coated vesicle	-	IDA	11517213
GO:0030479	actin cortical patch	-	IBA	21873635
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0098793	presynapse	-	IBA	21873635
GO:0098793	presynapse	-	IDA	20074057
GO:0098794	postsynapse	-	TAS	20074057
GO:0098888	extrinsic component of presynaptic membrane	-	IEA	-
GO:0098890	extrinsic component of postsynaptic membrane	-	IBA	21873635
GO:0098890	extrinsic component of postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25567908	Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)	Drilon A	Clin Cancer Res
26683835	Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. (2015 Dec 18)	Ahmad S	BMC Med Genet
23743675	A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. (2013 Oct)	Kapoor M	Hum Genet