Gene: HIVEP2

3097
HIV-EP2|MBP-2|MIBP1|MRD43|SHN2|ZAS2|ZNF40B
human immunodeficiency virus type I enhancer binding protein 2
protein-coding
6q24.2
Ensembl:ENSG00000010818 MIM:143054 Vega:OTTHUMG00000015713 UniprotKB:P31629
NG_047004.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.203e-1 (AD)  1.465e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7768492chr6:142824095 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKT30.955
ZFYVE90.954
MYCBP20.954
RNMT0.948
GSK3B0.947
DOCK30.947
SBNO10.946
ATP9A0.943
PAFAH1B10.942
RAPGEF20.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.492
HEY2-0.482
RAB13-0.48
CSAG1-0.475
RNF135-0.472
ROM1-0.465
OR4F5-0.462
COPZ2-0.46
AKR1C3-0.457
TMEM176A-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of HIVEP2 mRNA28329830
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of HIVEP2 mRNA"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HIVEP2 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HIVEP2 mRNA]"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HIVEP2 mRNA"19114083
C0261142-xylene2-xylene results in increased expression of HIVEP2 mRNA20359517
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HIVEP2 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HIVEP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HIVEP2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of HIVEP2 mRNA17562736
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HIVEP2 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HIVEP2 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HIVEP2 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of HIVEP2 mRNA"24160326|2575705
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HIVEP2 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of HIVEP2 mRNA25929836
D001554BenzeneBenzene results in increased expression of HIVEP2 mRNA20359517
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HIVEP2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HIVEP2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HIVEP2 mRNA21632981|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HIVEP2 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of HIVEP2 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of HIVEP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HIVEP2 gene28505145
D019327Copper SulfateCopper Sulfate results in increased expression of HIVEP2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of HIVEP2 mRNA20106945|2163298
D003907DexamethasoneDexamethasone results in decreased expression of HIVEP2 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HIVEP2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HIVEP2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HIVEP2 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of HIVEP2 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of HIVEP2 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of HIVEP2 mRNA16002434
C118739entinostatentinostat results in decreased expression of HIVEP2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP2 mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of HIVEP2 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIVEP2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HIVEP2 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HIVEP2 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HIVEP2 mRNA26865667
C004912ethylbenzeneethylbenzene results in increased expression of HIVEP2 mRNA20359517
D005419FlavonoidsFlavonoids results in increased expression of HIVEP2 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of HIVEP2 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of HIVEP2 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of HIVEP2 mRNA20655997|2341626
D019833GenisteinGenistein affects the expression of HIVEP2 mRNA26865667
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HIVEP2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HIVEP2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of HIVEP2 mRNA27392435
D007854LeadLead affects the expression of HIVEP2 mRNA28903495
D008752Methylene ChlorideMethylene Chloride results in increased expression of HIVEP2 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HIVEP2 mRNA28001369
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of HIVEP2 mRNA17412507
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of HIVEP2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HIVEP2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of HIVEP2 mRNA19812364
C022838nickel chloridenickel chloride results in increased expression of HIVEP2 mRNA17312168
D052638Particulate MatterParticulate Matter results in decreased expression of HIVEP2 mRNA22178795
D010634PhenobarbitalPhenobarbital affects the expression of HIVEP2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of HIVEP2 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HIVEP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of HIVEP2 mRNA12832660
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HIVEP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HIVEP2 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of HIVEP2 mRNA23012394
D011794QuercetinQuercetin results in increased expression of HIVEP2 mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of HIVEP2 mRNA21632981
C078903seocalcitolseocalcitol results in increased expression of HIVEP2 mRNA12040012
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of HIVEP2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HIVEP2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of HIVEP2 mRNA25351596
D012834SilverSilver results in increased expression of HIVEP2 mRNA26014281
D012834SilverSilver results in decreased expression of HIVEP2 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of HIVEP2 mRNA21795629
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of HIVEP2 mRNA16214533
C004648testosterone enanthatetestosterone enanthate affects the expression of HIVEP2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIVEP2 mRNA24058054|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HIVEP2 mRNA25613284
D014050TolueneToluene results in increased expression of HIVEP2 mRNA20359517
D014212TretinoinTretinoin results in increased expression of HIVEP2 mRNA21934132|2372400
C011559tributyltintributyltin results in decreased expression of HIVEP2 mRNA27614199
D014241TrichloroethyleneTrichloroethylene results in increased expression of HIVEP2 mRNA20359517
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HIVEP2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HIVEP2 mRNA"26179874
D014520UrethaneUrethane results in increased expression of HIVEP2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of HIVEP2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of HIVEP2 gene29154799
C025643vinclozolinvinclozolin results in increased expression of HIVEP2 mRNA23034163|2386920
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIVEP2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of HIVEP2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-TAS2022670  2247438  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal