Gene: ANXA11

311
ALS23|ANX11|CAP-50|CAP50
annexin A11
protein-coding
10q22.3
Ensembl:ENSG00000122359 MIM:602572 Vega:OTTHUMG00000018604 UniprotKB:P50995
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
8.876e-1 (AD)  2.952e-1 (ND)   (Frontal_Cortex)
8.654e-1 (AD)  4.315e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2789686chr10:80155380 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PI4K2A0.923
VPS26B0.922
PPP2R5D0.92
HK10.918
TMEM1270.918
CMIP0.917
NMT10.914
FBXO310.913
NEU10.913
IP6K10.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.646
OR4F29-0.596
CTNNA3-0.447
C5orf64-0.409
SH2D1A-0.402
ANXA13-0.382
TRPV5-0.364
RAI14-0.362
SGMS2-0.352
VRK2-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANXA11 mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of ANXA11 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA11 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ANXA11 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ANXA11 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA11 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ANXA11 mRNA21420995
C430898AGN 194204AGN 194204 results in increased expression of ANXA11 mRNA16339527
D000447AldehydesAldehydes results in decreased expression of ANXA11 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ANXA11 mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ANXA11 protein]26598702
C038328BEP protocolBEP protocol results in increased expression of ANXA11 mRNA18987330
C006780bisphenol Abisphenol A results in increased expression of ANXA11 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANXA11 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of ANXA11 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ANXA11 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ANXA11 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of ANXA11 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANXA11 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ANXA11 mRNA19320972|1937684
D003471CuprizoneCuprizone results in decreased expression of ANXA11 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ANXA11 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANXA11 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ANXA11 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ANXA11 mRNA28302478
C118739entinostatentinostat results in increased expression of ANXA11 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ANXA11 protein23301498
D000431EthanolEthanol results in increased expression of ANXA11 mRNA28986285
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANXA11 gene20938992
C039281furanfuran results in increased methylation of ANXA11 gene22079235
D005839GentamicinsGentamicins results in increased expression of ANXA11 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANXA11 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA11 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ANXA11 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of ANXA11 mRNA15476862
D007649KetamineKetamine results in increased expression of ANXA11 mRNA20080153
D018021Lithium ChlorideLithium Chloride results in increased expression of ANXA11 mRNA23527032
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ANXA11 gene20938992
D008727MethotrexateANXA11 protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ANXA11 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANXA11 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ANXA11 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANXA11 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ANXA11 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANXA11 mRNA"25554681
D009532NickelNickel results in decreased expression of ANXA11 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of ANXA11 mRNA19167457
C046012pentanalpentanal results in decreased expression of ANXA11 mRNA26079696
D010578PetroleumPetroleum affects the expression of ANXA11 mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA11 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANXA11 mRNA26272509
C005556propionaldehydepropionaldehyde results in decreased expression of ANXA11 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ANXA11 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of ANXA11 protein18089832
D018038Sodium SeleniteSodium Selenite results in increased expression of ANXA11 mRNA18175754
D053260SootSoot results in decreased expression of ANXA11 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANXA11 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANXA11 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANXA11 mRNA25613284
D014212TretinoinTretinoin results in increased expression of ANXA11 mRNA16249480|2193413
C012589trichostatin Atrichostatin A results in increased expression of ANXA11 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of ANXA11 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANXA11 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ANXA11 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ANXA11 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of ANXA11 mRNA15345369
C025643vinclozolinvinclozolin results in increased expression of ANXA11 mRNA22570695
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ANXA11 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI9268363  12445460  15197175  18256029  25910212  
GO:0005544calcium-dependent phospholipid binding-IEA-  
GO:0008429phosphatidylethanolamine binding-IEA-  
GO:0023026MHC class II protein complex binding-HDA20458337  
GO:0044548S100 protein binding-IPI12577318  19724273  
GO:0048306calcium-dependent protein binding-IPI11883939  12445460  
GO ID GO Term Qualifier Evidence PubMed
GO:0006909phagocytosis-IEP9188810  
GO:0032506cytokinetic process-IMP15197175  
GO:0051592response to calcium ion-IDA9188810  12601007  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IDA12601007  15197175  
GO:0005635nuclear envelope-NAS12577318  
GO:0005654nucleoplasm-IDA7508441  12601007  15197175  
GO:0005654nucleoplasm-NAS12577318  
GO:0005737cytoplasm-IDA7508441  12601007  12805373  
GO:0005819spindle-IDA12805373  15197175  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0030496midbody-IDA15197175  
GO:0042470melanosome-IEA-  
GO:0042581specific granule-IDA9188810  
GO:0042582azurophil granule-IDA9188810  
GO:0045335phagocytic vesicle-IDA9188810  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal