Gene: ANXA13

312
ANX13|ISA
annexin A13
protein-coding
8q24.13
Ensembl:ENSG00000104537 MIM:602573 Vega:OTTHUMG00000164987 UniprotKB:P27216
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.185e-1 (AD)  4.117e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17256536chr8:123686935 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20366110chr8:124720897ANXA131.900e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1390.725
SH2D1A0.722
SGMS20.718
VRK20.713
TRPV50.71
POU2AF10.708
LRRC630.694
FXYD40.689
RASGRP30.687
RHBDL20.672

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGAT5B-0.577
CUX2-0.54
PAK6-0.537
KCNQ4-0.533
TCERG1L-0.529
HAPLN4-0.525
CCKBR-0.511
CDH22-0.509
CA7-0.507
GABRD-0.506

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of ANXA13 mRNA"26377693
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of ANXA13 mRNA"21724226
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ANXA13 mRNA"21724226
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ANXA13 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of ANXA13 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANXA13 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of ANXA13 mRNA26690555|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ANXA13 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ANXA13 mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of ANXA13 mRNA21757418
D000447AldehydesAldehydes results in decreased expression of ANXA13 mRNA25014914
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of ANXA13 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of ANXA13 mRNA23912714
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ANXA13 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ANXA13 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ANXA13 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ANXA13 mRNA26079696
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ANXA13 mRNA24763279
D002509CephaloridineCephaloridine results in decreased expression of ANXA13 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANXA13 mRNA20938992
D016572CyclosporineCyclosporine results in decreased expression of ANXA13 mRNA27989131
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ANXA13 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ANXA13 mRNA25016146
D004147DioxinsDioxins affects the expression of ANXA13 mRNA20463971
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ANXA13 mRNA26159488
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA13 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ANXA13 mRNA23550701
D005485FlutamideFlutamide results in decreased expression of ANXA13 mRNA21126777
D005492Folic AcidFolic Acid affects the expression of ANXA13 mRNA17868486
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANXA13 mRNA20938992
C039281furanfuran results in increased expression of ANXA13 mRNA27387713
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ANXA13 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ANXA13 mRNA20044591
C051890irinotecanirinotecan analog results in decreased expression of ANXA13 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ANXA13 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ANXA13 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ANXA13 mRNA26752646
D008627Mercuric ChlorideMercuric Chloride affects the expression of ANXA13 protein21458406
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANXA13 mRNA20938992
C046012pentanalpentanal results in decreased expression of ANXA13 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of ANXA13 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ANXA13 mRNA28511854
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ANXA13 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ANXA13 mRNA17426115|2081375
C005556propionaldehydepropionaldehyde results in decreased expression of ANXA13 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ANXA13 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of ANXA13 mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of ANXA13 gene28589171
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ANXA13 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANXA13 mRNA22298810
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA13 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANXA13 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANXA13 mRNA21724226
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ANXA13 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of ANXA13 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ANXA13 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of ANXA13 mRNA20530235
D014635Valproic AcidValproic Acid results in decreased expression of ANXA13 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ANXA13 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of ANXA13 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005544calcium-dependent phospholipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030154cell differentiation-NAS1530946  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-NAS1530946  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal