Gene info: ID 323

Gene: APBB2

GENE ID: 323

Synonyms: FE65L|FE65L1

Description: amyloid beta precursor protein binding family B member 2

Gene type: protein-coding

Location: 4p14-p13

dbXrefs: Ensembl:ENSG00000163697 MIM:602710 Vega:OTTHUMG00000160416 UniprotKB:Q92870

RefSeq: NG_013337.1

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: OD|CD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.656e-1 (AD) 5.707e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs115368721	chr4:41054822 (GRCh38.p7)	G>A	opioid dependence	SNV(Single Nucleotide Variation)
rs114070671	chr4:41054699 (GRCh38.p7)	A>G	opioid dependence	SNV(Single Nucleotide Variation)
rs116478358	chr4:40826202 (GRCh38.p7)	T>A	cocaine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16547382	chr4:40863050	APBB2	Gene body	2.298e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DIP2B	0.879
LIMCH1	0.866
ERMP1	0.864
SECISBP2L	0.861
ANKIB1	0.849
ZNF146	0.847
STRN	0.846
FRYL	0.843
MPP5	0.84
SPAG9	0.84

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.581
OR4F5	-0.571
GOLGA6L1	-0.184
PLA2G5	-0.182
LCE5A	-0.177
ESPN	-0.176
PRTN3	-0.169
PAX2	-0.152
EPPIN	-0.149
NPAS4	-0.144

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of APBB2 mRNA	19933214
C038890	2,3,4,7,8-pentachlorodibenzofuran	"2,3,4,7,8-pentachlorodibenzofuran results in increased expression of APBB2 mRNA"	24046277
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of APBB2 mRNA"	20702594
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in increased expression of APBB2 mRNA"	24046277
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of APBB2 mRNA"	19167446
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of APBB2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of APBB2 mRNA	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of APBB2 mRNA	19770486
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of APBB2 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of APBB2 mRNA	26705709
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of APBB2 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of APBB2 mRNA	19770486\|2171566
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of APBB2 mRNA"	19150397\|2038263
D004958	Estradiol	Estradiol results in decreased expression of APBB2 mRNA	22467019
C006780	bisphenol A	bisphenol A affects the expression of APBB2 mRNA	20170705
C006780	bisphenol A	bisphenol A affects the expression of APBB2 mRNA	25181051
D002220	Carbamazepine	Carbamazepine affects the expression of APBB2 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of APBB2 mRNA	17484886
D002737	Chloroprene	Chloroprene results in increased expression of APBB2 mRNA	23125180
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of APBB2 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of APBB2 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of APBB2 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of APBB2 mRNA"	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of APBB2 mRNA	27989131
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of APBB2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of APBB2 mRNA	27392435
D004026	Dieldrin	Dieldrin affects the expression of APBB2 mRNA	22546817
D004237	Diuron	Diuron results in increased expression of APBB2 mRNA	21551480
C118739	entinostat	entinostat results in increased expression of APBB2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APBB2 mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of APBB2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APBB2 mRNA	17942748
D005472	Fluorouracil	APBB2 protein affects the susceptibility to Fluorouracil	16217747
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of APBB2 mRNA	22634610
D017313	Fenretinide	Fenretinide results in increased expression of APBB2 mRNA	28973697
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of APBB2 mRNA	27392435
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of APBB2 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
C022838	nickel chloride	nickel chloride affects the expression of APBB2 mRNA	22546817
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of APBB2 mRNA	25729387
D052638	Particulate Matter	[APBB2 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of APBB2 mRNA	21222557\|2122255
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APBB2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of APBB2 mRNA	22079256\|2271453
C045950	propiconazole	propiconazole results in decreased expression of APBB2 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of APBB2 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of APBB2 mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of APBB2 mRNA	21632981
C031389	resorcinol	resorcinol results in decreased expression of APBB2 mRNA	22623647
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of APBB2 mRNA	25351596
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APBB2 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of APBB2 mRNA	20702594\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APBB2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APBB2 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APBB2 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APBB2 mRNA	18796159\|2121527
C009495	titanium dioxide	titanium dioxide affects the expression of APBB2 mRNA	17656681
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of APBB2 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of APBB2 mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of APBB2 mRNA	23228038
D014212	Tretinoin	Tretinoin results in decreased expression of APBB2 mRNA	23724009
C012589	trichostatin A	trichostatin A results in increased expression of APBB2 mRNA	24935251
C057693	troglitazone	troglitazone results in decreased expression of APBB2 mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APBB2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of APBB2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of APBB2 mRNA	23179753\|2627250
D014638	Vanadates	Vanadates results in increased expression of APBB2 mRNA	22714537
D001335	Vehicle Emissions	[APBB2 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of APBB2 mRNA	21222557\|2122255
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of APBB2 gene	25560391
D014810	Vitamin E	Vitamin E results in decreased expression of APBB2 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of APBB2 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001540	amyloid-beta binding	-	IBA	21873635
GO:0001540	amyloid-beta binding	-	ISS	-
GO:0005515	protein binding	-	IPI	8855266 16273093 24658140
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0008134	transcription factor binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001764	neuron migration	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0006355	regulation of transcription, DNA-templated	-	ISS	-
GO:0007050	cell cycle arrest	-	ISS	-
GO:0007411	axon guidance	-	IEA	-
GO:0030198	extracellular matrix organization	-	IEA	-
GO:0030308	negative regulation of cell growth	-	ISS	-
GO:0035556	intracellular signal transduction	-	NAS	8855266
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	ISS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0016020	membrane	-	NAS	8855266
GO:0030027	lamellipodium	-	ISS	-
GO:0030426	growth cone	-	ISS	-
GO:0045202	synapse	-	ISS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29330135	APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment. (2018 Apr 20)	Liu CC	Prog Neuropsychopharmacol Biol Psychiatry