Gene: HTR7

3363
5-HT7
5-hydroxytryptamine receptor 7
protein-coding
10q23.31
Ensembl:ENSG00000148680 MIM:182137 Vega:OTTHUMG00000018732 UniprotKB:P34969
NG_029218.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.490e-2 (AD)  9.851e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12259062chr10:90850288 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10881838chr10:90830476 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11186320chr10:90816691 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3740046chr10:90741711 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPHKAP0.818
RAB3B0.817
ARHGAP200.812
GRIN3A0.812
GABRG30.807
XKR40.805
C8orf340.803
IL12RB20.796
KIAA10240.786
ARNTL20.783

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.57
IMPA2-0.553
NBPF10-0.537
PLIN4-0.531
HVCN1-0.528
PARD3B-0.517
ASB4-0.514
FXYD3-0.512
HIF3A-0.512
AKR1C3-0.509

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00216EletriptanSmall Molecule143322-58-1Approved|InvestigationalTarget
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00247MethysergideSmall Molecule361-37-5ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00434CyproheptadineSmall Molecule129-03-3ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00589LisurideSmall Molecule18016-80-3Approved|InvestigationalTarget
DB00734RisperidoneSmall Molecule106266-06-2Approved|InvestigationalTarget
DB00751EpinastineSmall Molecule80012-43-7Approved|InvestigationalTarget
DB00934MaprotilineSmall Molecule10262-69-8Approved|InvestigationalTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01267PaliperidoneSmall Molecule144598-75-4ApprovedTarget
DB04946IloperidoneSmall Molecule133454-47-4ApprovedTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB06288AmisulprideSmall Molecule71675-85-9Approved|InvestigationalTarget
DB08815LurasidoneSmall Molecule367514-87-2Approved|InvestigationalTarget
DB09068VortioxetineSmall Molecule508233-74-7Approved|InvestigationalTarget
DB09225ZotepineSmall Molecule26615-21-4Approved|Investigational|WithdrawnTarget
DB13988SB-269970Small Molecule201038-74-6InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0543632-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline binds to HTR7 protein20827463
C0543632-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
C1113093,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide"[3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]"14578406
C0470875-carboxamidotryptamine"[3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]"14578406
C0470875-carboxamidotryptamine[5-carboxamidotryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
C0470875-carboxamidotryptamine[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[Ketanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[Ritanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[Spiperone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C0470875-carboxamidotryptamine[volinanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C4165347-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide"7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide affects the activity of HTR7 protein"23611293
D000242Cyclic AMP"[3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]"14578406
D000242Cyclic AMP[5-carboxamidotryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D000242Cyclic AMP[5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D000242Cyclic AMP[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000242Cyclic AMP[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMPHTR7 results in increased abundance of Cyclic AMP10720076
D000242Cyclic AMP[Ketanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMP[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000242Cyclic AMP[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMP[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMP[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000242Cyclic AMP[Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000242Cyclic AMP[Methiothepin binds to and results in decreased activity of HTR7 protein] which results in decreased abundance of Cyclic AMP14578406
D000242Cyclic AMP[Methoxydimethyltryptamines binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D000242Cyclic AMP[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMP[Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000242Cyclic AMP[Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000242Cyclic AMP[Ritanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMP[Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D000242Cyclic AMP[Spiperone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D000242Cyclic AMP[volinanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HTR7 gene27153756
C439263AM 1241AM 1241 binds to HTR7 protein18931146
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR7 mRNA16483693
C505862AS 19 compoundAS 19 compound binds to and results in increased activity of HTR7 protein15936093
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HTR7 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of HTR7 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of HTR7 mRNA26186136
C006780bisphenol Abisphenol A results in increased methylation of HTR7 gene28505145
D001971BromocriptineBromocriptine binds to and results in decreased activity of HTR7 protein18996971|1950921
D001971Bromocriptine[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HTR7 mRNA23741332
D002118CalciumHTR7 protein promotes the reaction [[Freund's Adjuvant results in increased activity of TRPV1 protein] which results in increased transport of Calcium]16901936
D002220Carbamazepine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR7 mRNA22701549
D004390ChlorpyrifosChlorpyrifos affects the expression of HTR7 mRNA18835401
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR7 gene20938992
D003024Clozapine[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D003024ClozapineClozapine binds to HTR7 protein20827463
D003024ClozapineClozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D005576Colforsin[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D005576Colforsin[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D005576Colforsin[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D005576Colforsin[Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D005576Colforsin[Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D005576Colforsin[Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D003300CopperCopper deficiency results in increased expression of HTR7 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of HTR7 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of HTR7 mRNA26577399
D003533CyproheptadineCyproheptadine binds to HTR7 protein20827463
D003533CyproheptadineCyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of HTR7 mRNA23640034
D003976DiazinonDiazinon affects the expression of HTR7 mRNA17452286
D019422Dietary SucroseDietary Sucrose results in increased expression of HTR7 mRNA26033743
D005419FlavonoidsFlavonoids results in decreased expression of HTR7 mRNA18035473
D005472FluorouracilFluorouracil affects the expression of HTR7 mRNA16584549
D005473Fluoxetine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR7 mRNA22701549
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR7 gene20938992
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of HTR7 mRNA16901936
D005620Freund's AdjuvantHTR7 protein promotes the reaction [[Freund's Adjuvant results in increased activity of TRPV1 protein] which results in increased transport of Calcium]16901936
C039281furanfuran results in decreased methylation of HTR7 gene27387713
D012701Serotonin[Serotonin binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D019161Hydroxymethylglutaryl-CoA Reductase InhibitorsHTR7 gene SNP results in increased susceptibility to Hydroxymethylglutaryl-CoA Reductase Inhibitors17600820
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HTR7 mRNA25613284
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of HTR7 mRNA25119042
D007650Ketanserin[Ketanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D008070LipopolysaccharidesHTR7 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]15802305
D008070LipopolysaccharidesHTR7 protein promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]15802305
D008070LipopolysaccharidesHTR7 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]15802305
D008070LipopolysaccharidesHTR7 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]15802305
D008070LipopolysaccharidesHTR7 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]15802305
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HTR7 mRNA12057914
D008090LisurideLisuride binds to and results in decreased activity of HTR7 protein18996971|1950921
D008090Lisuride[Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D000069056Lurasidone HydrochlorideLurasidone Hydrochloride binds to and results in decreased activity of HTR7 protein20404009
D008628MercuryMercury results in increased expression of HTR7 mRNA16823088
C031649mesulergine[mesulergine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C031649mesulerginemesulergine binds to HTR7 protein20827463
C031649mesulerginemesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D008711MetergolineMetergoline binds to and results in decreased activity of HTR7 protein18996971|1950921
D008711Metergoline[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D008711Metergoline[Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR7 gene20938992
D008719MethiothepinMethiothepin binds to and results in decreased activity of HTR7 protein18996971|1950921
D008719Methiothepin[Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D008719Methiothepin[Methiothepin binds to and results in decreased activity of HTR7 protein] which results in decreased abundance of Cyclic AMP14578406
D008732Methoxydimethyltryptamines[Methoxydimethyltryptamines binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D0087355-Methoxytryptamine[5-Methoxytryptamine binds to and results in increased activity of HTR7 protein] which results in increased abundance of Cyclic AMP14578406
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HTR7 mRNA"20188158
D008803Mianserin[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D008803MianserinMianserin binds to HTR7 protein20827463
D008803MianserinMianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
C001801mitragyninemitragynine binds to HTR7 protein27192616
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HTR7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HTR7 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of HTR7 mRNA22714537
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of HTR7 mRNA19074003
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR7 protein15802305
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR7 protein18570192
D010100OxygenOxygen deficiency results in increased expression of HTR7 mRNA24236059
D000068882Paliperidone PalmitatePaliperidone Palmitate binds to and results in decreased activity of HTR7 protein18996971|1950921
D000068882Paliperidone Palmitate[Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of HTR7 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of HTR7 mRNA25119042
C000593032PGW5 compoundPGW5 compound binds to HTR7 protein24389121
D011441PropylthiouracilPropylthiouracil results in increased expression of HTR7 mRNA24780913
D018967Risperidone2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D018967RisperidoneClozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D018967RisperidoneCyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D018967Risperidonemesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D018967RisperidoneMianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D018967RisperidoneRisperidone binds to and results in decreased activity of HTR7 protein18996971|1950921
D018967Risperidone[Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]19509219
D018967RisperidoneSB 269970 inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
D016713Ritanserin[Ritanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C404922SB 269970SB 269970 binds to HTR7 protein20827463
C404922SB 269970SB 269970 inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]20827463
C404922SB 269970SB 269970 binds to and results in decreased activity of HTR7 protein18332680|1857019
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HTR7 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of HTR7 mRNA28595984
D013134Spiperone[Spiperone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
D013629TamoxifenTamoxifen results in decreased expression of HTR7 mRNA15590111
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of HTR7 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HTR7 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HTR7 mRNA25613284
D014212TretinoinTretinoin results in increased expression of HTR7 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HTR7 mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of HTR7 mRNA17127020
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HTR7 gene25560391
D000069470Venlafaxine Hydrochloride[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR7 mRNA22701549
C079049volinanserin[volinanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]14578406
C557874vortioxetinevortioxetine binds to and results in decreased activity of HTR7 protein21486038
D015032ZincZinc deficiency results in increased expression of HTR7 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006939smooth muscle contraction-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS8226867  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-IEA-  
GO:0007623circadian rhythm-IEA-  
GO:0008015blood circulation-TAS8226867  
GO:0042310vasoconstriction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8226867  
GO:0030425dendrite-IBA21873635  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390666Serotonin receptorsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15048644Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. (2004 Apr 1)Sullivan PFAm J Med Genet B Neuropsychiatr Genet
25070732Association between HTR7 genetic polymorphisms and alcohol dependence, using the alcohol use disorders identification test (AUDIT). (2014 Sep)Kim JHAlcohol Clin Exp Res
21184583Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. (2011 Jan)Zlojutro MAm J Med Genet B Neuropsychiatr Genet
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict
16340454Autosomal linkage analysis for the level of response to alcohol. (2005 Nov)Schuckit MAAlcohol Clin Exp Res