Gene: FAM170A

340069
ZNFD
family with sequence similarity 170 member A
protein-coding
5q23.1
Ensembl:ENSG00000164334 Vega:OTTHUMG00000162946 UniprotKB:A1A519
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.300e-1 (AD)  1.073e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12109691chr5:119630805 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR5H140.647
OR14A160.639
TMEM1740.582
DEFB1100.566
TCHHL10.561
OR5H20.544
HOXB10.537
OR2AP10.536
TAAR20.534
UGT3A10.534

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HOXC11-0.186
ZFHX4-AS1-0.183
C17orf100-0.181
MYBPC1-0.181
RSPH10B2-0.178
HIST2H2AA3-0.176
RXRG-0.167
FBXL13-0.167
KLHL40-0.165
MTRNR2L1-0.162

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D003471CuprizoneCuprizone results in increased expression of FAM170A mRNA26577399
D010936Plant ExtractsPlant Extracts results in decreased expression of FAM170A mRNA23557933
D012969Sodium FluorideSodium Fluoride results in decreased expression of FAM170A mRNA27862939
D014635Valproic AcidValproic Acid results in decreased methylation of FAM170A gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IDA20162441  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA20162441  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20162441  
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal