Gene info: ID 3480

Gene: IGF1R

GENE ID: 3480

Synonyms: CD221|IGFIR|IGFR|JTK13

Description: insulin like growth factor 1 receptor

Gene type: protein-coding

Location: 15q26.3

dbXrefs: Ensembl:ENSG00000140443 MIM:147370 Vega:OTTHUMG00000149851 UniprotKB:P08069

RefSeq: NG_009492.1

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.981e-1 (AD) 2.196e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4966017	chr15:98724404 (GRCh38.p7)	T>A / T>C / T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs3803476	chr15:98713341 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CREBBP	0.887
KMT2A	0.886
UBR2	0.884
EP300	0.878
KDM2A	0.874
NCOA6	0.869
EYA3	0.869
SMG1	0.868
SF3B3	0.866
TNRC6B	0.866

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.539
OR4F29	-0.509
GSDMC	-0.317
KLRC2	-0.29
XPNPEP2	-0.271
NANOGNB	-0.265
RERGL	-0.262
KLRB1	-0.256
CD8B	-0.255
CHP2	-0.255

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00030	Insulin Human	BiotechDrug	11061-68-0	Approved\|Investigational	Target
DB00046	Insulin Lispro	BiotechDrug	133107-64-9	Approved	Target
DB00047	Insulin Glargine	BiotechDrug	160337-95-1	Approved	Target
DB00071	Insulin Pork	BiotechDrug	12584-58-6	Approved	Target
DB01277	Mecasermin	BiotechDrug	68562-41-4	Approved\|Investigational	Target
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Small Molecule		Experimental	Target
DB05023	ATL1101	Small Molecule	-	Investigational	Target
DB05184	XL228	Small Molecule	-	Investigational	Target
DB05897	rhIGFBP-3	Small Molecule	-	Investigational	Target
DB06075	Linsitinib	Small Molecule	867160-71-2	Investigational	Target
DB07156	(4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione	Small Molecule		Experimental	Target
DB07474	3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE	Small Molecule		Experimental	Target
DB09098	Somatrem	BiotechDrug	82030-87-3	Approved\|Investigational\|Withdrawn	Target
DB12250	Cixutumumab	BiotechDrug	947687-12-9	Investigational	Target
DB12267	Brigatinib	Small Molecule	1197953-54-0	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of IGF1R mRNA"	26377693
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased phosphorylation of and results in increased activity of IGF1R protein"	10965916
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"ESR1 protein promotes the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased phosphorylation of and results in increased activity of IGF1R protein]"	10965916
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl affects the expression of IGF1R mRNA"	21703328
C525063	2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone	"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]"	25643584
C525063	2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone	"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone results in decreased phosphorylation of IGF1R protein"	25643584
C525063	2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone	"IGF1R protein modified form results in increased susceptibility to 2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone"	25643584
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGF1R mRNA"	23196670
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of IGF1R mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF1R mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF1R mRNA"	27188386
C568862	4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline	"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]"	29090346
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of IGF1R mRNA	12419474
C014036	4-hydroxyestradiol	4-hydroxyestradiol results in increased expression of IGF1R protein	23685341
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of IGF1R mRNA	20829426
C030371	5,6,7,8-tetrahydrofolic acid	"5,6,7,8-tetrahydrofolic acid results in decreased expression of IGF1R mRNA"	16728583
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF1R mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF1R mRNA"	27188386
C119737	8-prenylnaringenin	8-prenylnaringenin results in increased expression of IGF1R mRNA	16522720
D000082	Acetaminophen	Acetaminophen affects the expression of IGF1R mRNA	17562736
D000082	Acetaminophen	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of IGF1R mRNA	25607892
D000086	Acetazolamide	Acetazolamide results in increased expression of IGF1R mRNA	19274763
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IGF1R protein]	21195169
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of IGF1R mRNA]	21233418
C016601	afimoxifene	IGF1R results in decreased susceptibility to afimoxifene	21233418
C016601	afimoxifene	afimoxifene results in increased expression of IGF1R mRNA	17640349
C016601	afimoxifene	afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein	10965916
C016601	afimoxifene	ESR1 protein promotes the reaction [afimoxifene results in increased phosphorylation of and results in increased activity of IGF1R protein]	10965916
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of and results in increased phosphorylation of IGF1R protein	20036727
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGF1R mRNA	20036727
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGF1R protein	20036727
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of IGF1R protein modified form	24373827
C412373	AG 1879	AG 1879 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]	19815064
C419770	AG 538	AG 538 results in decreased activity of IGF1R protein	22067323
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of IGF1R mRNA	28070108
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of IGF1R mRNA	18491370
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of IGF1R protein	18491370
D013196	Dihydrotestosterone	Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]	18491370
D013196	Dihydrotestosterone	Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]	18491370
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of IGF1R protein	10650946
D013196	Dihydrotestosterone	nilutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of IGF1R protein]	10650946
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1R mRNA]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1R mRNA]]	25309793
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IGF1R mRNA	16483693
D000726	Androgen Antagonists	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of IGF1R mRNA	25607892
D000880	Anthraquinones	Anthraquinones analog results in decreased activity of IGF1R protein	27473261
D000970	Antineoplastic Agents	Antineoplastic Agents results in decreased expression of IGF1R protein	20652976
D000970	Antineoplastic Agents	Antineoplastic Agents results in decreased expression of IGF1R protein modified form	20652976
D001151	Arsenic	Arsenic affects the methylation of IGF1R gene	25304211
D001152	Arsenicals	Arsenicals results in increased expression of IGF1R mRNA	28237603
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of IGF1R mRNA	19769630
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IGF1R mRNA	23911876
C006632	arsenic trioxide	IGF1R mRNA affects the susceptibility to arsenic trioxide	23911876
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of IGF1R mRNA	24831965
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of IGF1R mRNA"	23634900
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of IGF1R protein	20530736
D001379	Azathioprine	Azathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	23958494
D001379	Azathioprine	Azathioprine results in decreased expression of IGF1R protein	23958494
C547126	AZM551248	AZM551248 results in decreased expression of IGF1R mRNA	22323515
D001397	Azoxymethane	[Plant Extracts co-treated with Azoxymethane] results in decreased expression of IGF1R mRNA	23996930
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased phosphorylation of IGF1R protein	9683191
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of IGF1R mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGF1R mRNA	15034205\|2180369
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IGF1R mRNA"	19150397\|2001819
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [platycodin D results in decreased expression of IGF1R protein]	28711525
D001599	Berberine	Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]	23954465
D001599	Berberine	Berberine results in increased expression of IGF1R protein	23954465
D004958	Estradiol	[Estradiol co-treated with IGF1R mutant form] results in decreased expression of CDK2 mRNA	23094148
D004958	Estradiol	[Estradiol co-treated with IGF1R mutant form] results in increased expression of CCND2 mRNA	23094148
D004958	Estradiol	[Estradiol co-treated with IGF1R mutant form] results in increased expression of EGFR mRNA	23094148
D004958	Estradiol	[Estradiol co-treated with IGF1R mutant form] results in increased expression of MAP3K1 mRNA	23094148
D004958	Estradiol	[Estradiol co-treated with IGF1R mutant form] results in increased expression of MAP4K1 mRNA	23094148
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to IGF1R protein]	19815064\|2309414
D004958	Estradiol	Estradiol promotes the reaction [SHC1 protein binds to IGF1R protein]	16024245
D004958	Estradiol	Estradiol results in increased expression of IGF1R mRNA	11813992\|1755586
D004958	Estradiol	Estradiol results in increased phosphorylation of IGF1R protein	16024245\|2309414
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]	23810794
D004958	Estradiol	fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]	19879930
D004958	Estradiol	Genistein inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]	23933164
D004958	Estradiol	[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein	19879930
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SHC1 protein]]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of CCNA1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of CCNB1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of DLK1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of ETS2 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of HSPA5 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of MAPK9 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of NFATC4 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in decreased expression of PAK1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of ARAF mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of CCNB2 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of CDK4 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of COL1A1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of GRB2 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K2 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K4 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAPK11 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAPK13 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MEF2C mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of NRAS mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of RAC1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]	23094148
D004958	Estradiol	IGF1R mutant form promotes the reaction [Estradiol results in increased expression of CCND3 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form promotes the reaction [Estradiol results in increased expression of EGR1 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form promotes the reaction [Estradiol results in increased expression of MAP3K4 mRNA]	23094148
D004958	Estradiol	IGF1R mutant form promotes the reaction [Estradiol results in increased expression of MAX mRNA]	23094148
D004958	Estradiol	IGF1R mutant form promotes the reaction [Estradiol results in increased expression of MYC mRNA]	23094148
D004958	Estradiol	resveratrol inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]	18586690\|2381079
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in decreased expression of IGF1R mRNA]	25210133
D004958	Estradiol	Estradiol affects the reaction [CYP19A1 affects the expression of IGF1R mRNA]	11985600
D004958	Estradiol	Estradiol results in decreased expression of IGF1R mRNA	14664709\|2521013
D004958	Estradiol	Estradiol results in increased expression of IGF1R mRNA	17640349
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of IGF1R mRNA	26496021
D004958	Estradiol	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA	22465879
D004958	Estradiol	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein	22465879
D004958	Estradiol	Estradiol results in decreased expression of IGF1R mRNA	20068009\|2038159
D004958	Estradiol	Estradiol results in increased expression of IGF1R mRNA	16522720
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in increased expression of IGF1R mRNA	17640349
C006780	bisphenol A	bisphenol A results in decreased expression of IGF1R mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased expression of IGF1R mRNA	23810794\|2393316
C006780	bisphenol A	bisphenol A results in increased methylation of IGF1R gene	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of IGF1R promoter	27271280
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]	23810794
C006780	bisphenol A	Genistein inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]	23933164
C006780	bisphenol A	resveratrol inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]	23810794
C006780	bisphenol A	bisphenol A affects the reaction [CYP19A1 affects the expression of IGF1R mRNA]	11985600
C006780	bisphenol A	bisphenol A results in increased phosphorylation of and results in increased activity of IGF1R protein	10965916
C006780	bisphenol A	bisphenol A results in increased phosphorylation of IGF1R protein	21988766
C006780	bisphenol A	ESR1 protein promotes the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of IGF1R protein]	10965916
C006780	bisphenol A	bisphenol A results in decreased expression of IGF1R mRNA	20505776
C006780	bisphenol A	bisphenol A affects the expression of IGF1R mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of IGF1R mRNA	25607892
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of IGF1R mRNA	26496021
C504983	BMS 536924	BMS 536924 results in decreased phosphorylation of IGF1R protein	26394120
C545990	BMS 754807	[BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein	24986516
C545990	BMS 754807	BMS 754807 results in decreased phosphorylation of IGF1R protein	24986516
D000069286	Bortezomib	IGF1R gene SNP results in increased susceptibility to Bortezomib	20864405
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of IGF1R mRNA	12419474
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of IGF1R mRNA	25607892
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of IGF1R mRNA	17481689
D002104	Cadmium	Cadmium promotes the reaction [IGF1 protein binds to IGF1R protein]	9648927
D002104	Cadmium	Cadmium promotes the reaction [IGF2 protein binds to IGF1R protein]	9648927
D002104	Cadmium	Cadmium results in increased expression of IGF1R mRNA	24376830
D019256	Cadmium Chloride	[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]	23673518
D019256	Cadmium Chloride	[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]	23673518
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of IGF1R mRNA	15501611
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IGF1R protein]	21195169
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of IGF1R protein	21195169
D002110	Caffeine	Caffeine results in decreased expression of IGF1R mRNA	22583948
D002110	Caffeine	Caffeine results in decreased expression of IGF1R protein	22583948
C459604	candoxin	candoxin results in decreased expression of IGF1R mRNA	16309724
D002211	Capsaicin	Capsaicin results in increased expression of IGF1R mRNA	21310942
D002211	Capsaicin	TRPV1 affects the reaction [Capsaicin results in increased expression of IGF1R mRNA]	21310942
D002220	Carbamazepine	Carbamazepine affects the expression of IGF1R mRNA	24752500
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with epigallocatechin gallate] results in decreased expression of IGF1R mRNA	19646978
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of IGF1R mRNA	17805973
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGF1R mRNA	27350269
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGF1R protein	12800242\|2735026
D002251	Carbon Tetrachloride	IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of IGF1R protein]	12800242
C057774	chimaphilin	chimaphilin results in decreased expression of IGF1R protein	25980584
C057774	chimaphilin	chimaphilin results in decreased expression of IGF1R protein modified form	25980584
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of IGF1R mRNA	23650126
C100187	chloropicrin	chloropicrin results in increased expression of IGF1R mRNA	26352163
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of IGF1R protein	23748240
C074702	chromium hexavalent ion	MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IGF1R protein]	23748240
C043561	chrysin	chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]	29247772
D004002	Clodronic Acid	Clodronic Acid results in increased expression of IGF1R mRNA	25596134
D003042	Cocaine	Cocaine affects the expression of IGF1R mRNA	20187946
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in decreased expression of IGF1R protein	20931265
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in decreased phosphorylation of IGF1R protein	20931265
D003300	Copper	Copper deficiency results in increased expression of IGF1R protein	15734878
D003300	Copper	[H 1356 results in decreased activity of IGF1R protein] which results in decreased susceptibility to Copper deficiency	15734878
C113861	corosolic acid	corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein]	26513295
D003345	Corticosterone	Corticosterone results in decreased expression of IGF1R protein	12807724
D003345	Corticosterone	[IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]	24667322
D003471	Cuprizone	Cuprizone results in increased expression of IGF1R mRNA	26577399
D003474	Curcumin	Curcumin analog results in decreased expression of IGF1R mRNA	26409325
D003474	Curcumin	Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]	17499312
D003474	Curcumin	Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]	17918158
D003474	Curcumin	Curcumin results in decreased expression of IGF1R mRNA	17499312
D003474	Curcumin	Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein	17918158
D003474	Curcumin	Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]	17918158
D016572	Cyclosporine	Cyclosporine results in decreased expression of IGF1R mRNA	25562108
C017160	cypermethrin	cypermethrin results in increased expression of IGF1R mRNA	27704156
C004742	daidzein	daidzein results in decreased expression of IGF1R mRNA	16865672
D003622	Dapsone	Dapsone analog inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]	21440447
C107676	deguelin	deguelin metabolite results in decreased expression of IGF1R protein	19139008
C107676	deguelin	deguelin results in decreased expression of IGF1R protein	19139008
D013759	Dronabinol	Dronabinol results in increased expression of IGF1R mRNA	16597638
D003847	Deoxyglucose	Deoxyglucose results in increased phosphorylation of and results in increased activity of IGF1R protein	23041229
D003907	Dexamethasone	Dexamethasone results in decreased expression of IGF1R mRNA	25047013
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IGF1R mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of IGF1R mRNA	19853640
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IGF1R mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IGF1R mRNA	15829613
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IGF1R protein	15829613
D002945	Cisplatin	Cisplatin results in decreased expression of IGF1R mRNA	27594783
D002945	Cisplatin	IGF1R protein results in decreased susceptibility to Cisplatin	21442237
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of IGF1R mRNA	16764480
D004008	Diclofenac	Diclofenac affects the expression of IGF1R mRNA	24752500
C000944	dicrotophos	dicrotophos results in increased expression of IGF1R mRNA	28302478
D004041	Dietary Fats	[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1R mRNA	24275070
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of IGF1R mRNA	19542621
D004052	Diethylnitrosamine	[Mastic Resin co-treated with Diethylnitrosamine] results in decreased expression of IGF1R mRNA	18977376
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of IGF1R mRNA	15171707
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased phosphorylation of and results in increased activity of IGF1R protein	10965916
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased phosphorylation of IGF1R protein	15171707
D004054	Diethylstilbestrol	ESR1 protein promotes the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of IGF1R protein]	10965916
C010920	dihydrofolate	dihydrofolate results in decreased expression of IGF1R mRNA	16728583
D002117	Calcitriol	Calcitriol affects the expression of IGF1R mRNA	19918113
D002117	Calcitriol	Calcitriol results in increased expression of IGF1R mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of IGF1R mRNA	21592394
D004178	Diquat	IGF1R protein results in increased susceptibility to Diquat	22132081
D004317	Doxorubicin	IGF1R protein results in decreased susceptibility to Doxorubicin	25980584
D004317	Doxorubicin	Doxorubicin results in increased expression of IGF1R mRNA	25896364
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of IGF1R mRNA	25607892
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of IGF1R protein modified form	20346928
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of IGF1R mRNA	22079256
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IGF1R mRNA	22079256
C045651	epigallocatechin gallate	[Carbon Tetrachloride co-treated with epigallocatechin gallate] results in decreased expression of IGF1R mRNA	19646978
D060754	Equol	Equol results in decreased expression of IGF1R mRNA	16865672
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate affects the expression of IGF1R mRNA	15059950
C025483	estradiol-17 beta-glucuronide	"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]"	29090346
C025483	estradiol-17 beta-glucuronide	estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein	29090346
C025483	estradiol-17 beta-glucuronide	IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]	29090346
C025483	estradiol-17 beta-glucuronide	IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]	29090346
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of IGF1R mRNA	21323755
C074283	estradiol 3-benzoate	Progesterone inhibits the reaction [estradiol 3-benzoate results in increased expression of IGF1R mRNA]	21323755
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of IGF1R mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of IGF1R mRNA	21233418
D000431	Ethanol	[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1R mRNA	24275070
D000431	Ethanol	Ethanol results in increased activity of IGF1R protein	19735724
D000431	Ethanol	Polysaccharides promotes the reaction [Ethanol results in increased activity of IGF1R protein]	19735724
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGF1R mRNA	17222921
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IGF1R mRNA	23261820
D004997	Ethinyl Estradiol	fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of IGF1R mRNA]	23261820
D004997	Ethinyl Estradiol	fulvestrant inhibits the reaction [[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA]	23261820
D004997	Ethinyl Estradiol	[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA	23261820
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of IGF1R mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of IGF1R gene	16461637
D005047	Etoposide	IGF1R protein affects the susceptibility to Etoposide	15499378
D000068338	Everolimus	Everolimus results in increased expression of IGF1R mRNA	28711525
D000068338	Everolimus	Everolimus results in increased expression of IGF1R protein	28711525
D000068338	Everolimus	platycodin D inhibits the reaction [Everolimus results in increased expression of IGF1R protein]	28711525
D005227	Fatty Acids	[Fatty Acids co-treated with INS protein] affects the phosphorylation of IGF1R protein	24648896
D005227	Fatty Acids	Quercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IGF1R protein]	24648896
D005472	Fluorouracil	Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]	17918158
D005472	Fluorouracil	Fluorouracil results in decreased phosphorylation of and results in decreased activity of IGF1R protein	17918158
D005485	Flutamide	Flutamide results in decreased expression of IGF1R mRNA	17222921
C410216	Folfox protocol	Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]	17918158
C410216	Folfox protocol	Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein	17918158
D005492	Folic Acid	Folic Acid inhibits the reaction [IGF1R protein results in increased phosphorylation of MAPK1 protein]	16728583
D005492	Folic Acid	Folic Acid inhibits the reaction [IGF1R protein results in increased phosphorylation of MAPK3 protein]	16728583
D005492	Folic Acid	Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter]	16728583
D005492	Folic Acid	Folic Acid results in decreased expression of IGF1R mRNA	16728583
D005492	Folic Acid	Folic Acid results in decreased expression of IGF1R protein	16728583
D005492	Folic Acid	Folic Acid results in increased expression of IGF1R mRNA	8594875
D005557	Formaldehyde	Formaldehyde results in increased expression of IGF1R mRNA	23649840
C070081	fulvestrant	AG 1879 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]	19815064
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]	23810794
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]	23810794
C070081	fulvestrant	fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]	19879930
C070081	fulvestrant	fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]	19879930
C070081	fulvestrant	fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]	19815064
C070081	fulvestrant	fulvestrant results in increased phosphorylation of IGF1R protein	19815064
C070081	fulvestrant	tyrphostin AG 1024 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]	19815064
C070081	fulvestrant	fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of IGF1R mRNA]	23261820
C070081	fulvestrant	fulvestrant inhibits the reaction [[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA]	23261820
C419708	gefitinib	gefitinib promotes the reaction [IGF1R protein binds to EGFR protein]	17473213
C419708	gefitinib	gefitinib results in increased phosphorylation of IGF1R protein	17473213
C419708	gefitinib	tyrphostin AG 1024 inhibits the reaction [gefitinib results in increased phosphorylation of IGF1R protein]	17473213
C056507	gemcitabine	gemcitabine results in decreased expression of IGF1R mRNA	20103597
D019833	Genistein	Genistein inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]	23933164
D019833	Genistein	Genistein inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]	23933164
D019833	Genistein	Genistein results in decreased expression of IGF1R mRNA	16865672
D019833	Genistein	ESR1 protein promotes the reaction [Genistein results in increased phosphorylation of and results in increased activity of IGF1R protein]	10965916
D019833	Genistein	Genistein results in increased phosphorylation of and results in increased activity of IGF1R protein	10965916
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of IGF1R mRNA	16443925
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of IGF1R protein	16443925
D019833	Genistein	Genistein results in increased expression of IGF1R mRNA	16443925\|1704984
D019833	Genistein	Genistein results in increased expression of IGF1R protein	16443925
D019833	Genistein	[Methoxychlor co-treated with Genistein] results in increased expression of IGF1R protein	11896288
D005839	Gentamicins	Gentamicins results in increased expression of IGF1R mRNA	22061828
D005947	Glucose	Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]	23954465
D005947	Glucose	Glucose results in decreased expression of IGF1R protein	23954465
D005947	Glucose	Glucose results in increased expression of IGF1R mRNA	7826318
D006046	Gold	Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]	9648927
D006046	Gold	Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]	9648927
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1R mRNA]]	25309793
C411572	H 1356	H 1356 results in decreased activity of IGF1R protein	15734878
C411572	H 1356	[H 1356 results in decreased activity of IGF1R protein] which results in decreased susceptibility to Copper deficiency	15734878
D006581	Hexachlorobenzene	fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]	19879930
D006581	Hexachlorobenzene	fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]	19879930
D006581	Hexachlorobenzene	[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein	19879930
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of IGF1R protein	19879930
D006581	Hexachlorobenzene	Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein]	16237195
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of IGF1R protein	16237195
D017313	Fenretinide	Fenretinide results in increased expression of IGF1R mRNA	28973697
D006861	Hydrogen Peroxide	IGF1R gene mutant form results in decreased susceptibility to Hydrogen Peroxide	15761239
D007213	Indomethacin	Indomethacin results in increased expression of IGF1R mRNA	18299717
D000069036	Insulin Glargine	Insulin Glargine results in increased phosphorylation of and results in increased activity of IGF1R protein	24464500
D000069036	Insulin Glargine	Insulin Glargine results in increased phosphorylation of IGF1R protein	27884723
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IGF1R mRNA	16054899
D007530	Isoflurane	Isoflurane results in decreased phosphorylation of IGF1R protein	25597859
D007545	Isoproterenol	Isoproterenol results in increased expression of IGF1R mRNA	20003209
C561695	(+)-JQ1 compound	IGF1 protein inhibits the reaction [(+)-JQ1 compound results in decreased phosphorylation of IGF1R protein]	27259270
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased phosphorylation of IGF1R protein	27259270
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IGF1R mRNA	25982114
D016729	Leuprolide	Leuprolide results in decreased expression of and results in decreased phosphorylation of IGF1R protein	17143537
C027820	ligustilide	ligustilide results in decreased phosphorylation of IGF1R protein	23973442
D008043	Linseed Oil	Linseed Oil results in decreased expression of IGF1R mRNA	19904759
D008043	Linseed Oil	Linseed Oil results in decreased expression of IGF1R mRNA	21138602
D008044	Linuron	Linuron results in decreased expression of IGF1R mRNA	12730624
D008148	Lovastatin	Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]	19741129
C115121	LY 353381	ESR1 protein promotes the reaction [LY 353381 results in increased phosphorylation of and results in increased activity of IGF1R protein]	10965916
C115121	LY 353381	LY 353381 results in increased phosphorylation of and results in increased activity of IGF1R protein	10965916
C015329	lycopene	lycopene results in decreased expression of IGF1R protein	17337101
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IGF1R mRNA	26378955
C025340	manganese chloride	manganese chloride results in decreased expression of IGF1R mRNA	19276553
C025340	manganese chloride	manganese chloride results in increased expression of IGF1R protein	21402727
C412811	maslinic acid	maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein]	26513295
D009637	Masoprocol	Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]	18491370
D009637	Masoprocol	Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]	18491370
D009637	Masoprocol	Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]	18491370
D009637	Masoprocol	Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	18645000
D009637	Masoprocol	Masoprocol results in decreased activity of IGF1R protein	18491370
D000069997	Mastic Resin	[Mastic Resin co-treated with Diethylnitrosamine] results in decreased expression of IGF1R mRNA	18977376
D008687	Metformin	[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA	21664031
D008687	Metformin	[Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA	21664031
D008687	Metformin	[Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA	21664031
D008687	Metformin	Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]	26492952
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of IGF1R mRNA	16443925
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of IGF1R protein	16443925
D008731	Methoxychlor	[Methoxychlor co-treated with Genistein] results in increased expression of IGF1R protein	11896288
D008731	Methoxychlor	Methoxychlor results in decreased expression of IGF1R mRNA	23303685
D008731	Methoxychlor	Methoxychlor results in increased expression of IGF1R mRNA	16443925
D008731	Methoxychlor	Methoxychlor results in increased expression of IGF1R protein	16443925
D008731	Methoxychlor	Methoxychlor results in increased methylation of IGF1R gene	23303685
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of IGF1R mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF1R mRNA"	27188386
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of IGF1R mRNA	20864626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of IGF1R mRNA	23649840
D008770	Methylnitrosourea	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA	22465879
D008770	Methylnitrosourea	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein	22465879
D008770	Methylnitrosourea	Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein]	16237195
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of IGF1R protein	16237195
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of IGF1R protein	26364587
D015655	1-Methyl-4-phenylpyridinium	INS protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1R protein]	26364587
D015741	Metribolone	Dapsone analog inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]	21440447
D015741	Metribolone	Metribolone results in increased expression of IGF1R mRNA	18586690\|2144044
D015741	Metribolone	resveratrol inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]	18586690
D008942	Mitoxantrone	IGF1R protein affects the susceptibility to Mitoxantrone	15499378
C020300	monomethylarsonic acid	monomethylarsonic acid results in increased expression of IGF1R mRNA	17481689
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IGF1R protein	24625837
C047806	monomethylpropion	monomethylpropion results in increased expression of IGF1R mRNA	22303338
C455139	myrtucommulone A	myrtucommulone A results in decreased expression of IGF1R mRNA	26032814
C568507	N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide	"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of IGF1R protein"	21888390
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of IGF1R mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of IGF1R mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of IGF1R mRNA	25583101
C017557	nickel subsulfide	nickel subsulfide affects the expression of IGF1R mRNA	24952340
D009534	Niclosamide	IGF1R protein affects the susceptibility to Niclosamide	27497986
D009538	Nicotine	Nicotine results in decreased expression of IGF1R mRNA	22265867
D009538	Nicotine	Nicotine results in decreased expression of IGF1R protein	20960268
D009538	Nicotine	Nicotine results in increased expression of IGF1R mRNA	20426880
C021277	nilutamide	nilutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of IGF1R protein]	10650946
C007350	nitrofen	nitrofen results in decreased expression of IGF1R mRNA	20620343\|2143327
C007350	nitrofen	nitrofen results in decreased expression of IGF1R protein	20620343\|2143327
C007350	nitrofen	Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF1R mRNA]	21433279
C007350	nitrofen	Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF1R protein]	21433279
D009588	Nitrogen Mustard Compounds	IGF1R protein affects the susceptibility to Nitrogen Mustard Compounds	15499378
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of IGF1R protein	21411721
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]"	14644152
C502355	NVP ADW742	NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	16740780
C502355	NVP ADW742	NVP ADW742 results in decreased activity of IGF1R protein	16740780
C501177	NVP-AEW541	NVP-AEW541 results in decreased phosphorylation of IGF1R protein	20664932
C501177	NVP-AEW541	NVP-AEW541 inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	27734117
C501177	NVP-AEW541	[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	27734117
C025589	ochratoxin A	ochratoxin A results in increased expression of IGF1R protein	17651772
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of IGF1R mRNA	25607892
D010126	Ozone	Ozone results in increased expression of IGF1R mRNA	16330353
C500026	palbociclib	[BMS 754807 co-treated with palbociclib] results in decreased phosphorylation of IGF1R protein	24986516
D010269	Paraquat	IGF1R protein affects the susceptibility to Paraquat	23898955
D010269	Paraquat	Paraquat results in increased expression of and results in increased phosphorylation of IGF1R protein	23898955
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of IGF1R mRNA	19397962
D010575	Pesticides	Pesticides results in increased methylation of IGF1R gene	28396702
D010634	Phenobarbital	Phenobarbital affects the expression of IGF1R mRNA	23091169
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of IGF1R mRNA	21061450
C030614	picolinic acid	picolinic acid promotes the reaction [INS1 protein results in increased expression of IGF1R mRNA]	20013160
C415032	picropodophyllin	picropodophyllin results in decreased activity of IGF1R protein	16166596
C415032	picropodophyllin	[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]	23673518
C415032	picropodophyllin	[picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]	23673518
C415032	picropodophyllin	picropodophyllin binds to and results in decreased activity of IGF1R protein	21371294
C415032	picropodophyllin	picropodophyllin results in decreased activity of IGF1R protein	23143138\|2367351
C008922	piperine	piperine binds to IGF1R protein	28341137
D010936	Plant Extracts	[Plant Extracts co-treated with Azoxymethane] results in decreased expression of IGF1R mRNA	23996930
C108953	platycodin D	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [platycodin D results in decreased expression of IGF1R protein]	28711525
C108953	platycodin D	platycodin D inhibits the reaction [Everolimus results in increased expression of IGF1R protein]	28711525
C108953	platycodin D	platycodin D results in decreased expression of IGF1R protein	28711525
D011134	Polysaccharides	Polysaccharides promotes the reaction [Ethanol results in increased activity of IGF1R protein]	19735724
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IGF1R mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of IGF1R mRNA	22079256
C569479	PQ 401	PQ 401 results in decreased activity of IGF1R protein	23041229
D011374	Progesterone	Progesterone inhibits the reaction [estradiol 3-benzoate results in increased expression of IGF1R mRNA]	21323755
D011374	Progesterone	Progesterone results in decreased expression of IGF1R mRNA	18070364
D011374	Progesterone	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA	22465879
D011374	Progesterone	[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein	22465879
D011374	Progesterone	Progesterone results in increased expression of IGF1R mRNA	19853640
D011794	Quercetin	Quercetin affects the reaction [[Fatty Acids co-treated with INS protein] affects the phosphorylation of IGF1R protein]	24648896
D011794	Quercetin	Quercetin results in decreased expression of IGF1R mRNA	20596804\|2065831
D011794	Quercetin	Quercetin results in decreased expression of IGF1R protein	12653748\|2065831
D011794	Quercetin	Quercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	24353828
C012526	quercitrin	quercitrin affects the expression of IGF1R mRNA	25193878
C059514	resveratrol	resveratrol results in increased expression of IGF1R mRNA	24305840
C059514	resveratrol	resveratrol inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]	23810794
C059514	resveratrol	resveratrol inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]	18586690\|2381079
C059514	resveratrol	resveratrol inhibits the reaction [IGF1 protein binds to and results in increased phosphorylation of and results in increased activity of IGF1R protein]	24782617
C059514	resveratrol	resveratrol inhibits the reaction [Metribolone results in increased expression of IGF1R mRNA]	18586690
C059514	resveratrol	resveratrol results in decreased expression of IGF1R mRNA	18586690\|2381079
C059514	resveratrol	resveratrol results in decreased expression of IGF1R protein	20504360
C059514	resveratrol	resveratrol results in decreased phosphorylation of IGF1R protein	26394120
C059514	resveratrol	resveratrol inhibits the reaction [IGF1 protein binds to and results in increased phosphorylation of and results in increased activity of IGF1R protein]	24782617
C059514	resveratrol	resveratrol results in increased expression of IGF1R mRNA	23525482
C059514	resveratrol	resveratrol results in increased expression of IGF1R protein	17675339\|2433039
C059514	resveratrol	resveratrol results in increased expression of IGF1R mRNA	23848300
C021828	Revalor	Revalor affects the expression of IGF1R mRNA	24987078
C089730	rosiglitazone	rosiglitazone inhibits the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]	18670617
C089730	rosiglitazone	rosiglitazone inhibits the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	18670617
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IGF1R mRNA	16054899
C089730	rosiglitazone	rosiglitazone results in decreased expression of IGF1R mRNA	17122083
C086511	RU 58668	RU 58668 affects the expression of IGF1R protein	15868441
D012431	Rutin	Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein]	20015448
C090142	secoisolariciresinol diglucoside	secoisolariciresinol diglucoside results in decreased expression of IGF1R mRNA	19904759
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of IGF1R mRNA	18514395
D019821	Simvastatin	Simvastatin results in decreased expression of IGF1R	17158816
D019821	Simvastatin	Simvastatin results in decreased expression of IGF1R mRNA	18489904
D019821	Simvastatin	Simvastatin results in decreased expression of IGF1R protein	18489904
D019821	Simvastatin	[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	27734117
D019821	Simvastatin	Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	27734117
D019821	Simvastatin	Simvastatin results in increased expression of IGF1R protein alternative form	17327694
D020123	Sirolimus	Sirolimus affects the activity of IGF1R protein	16227402
D020123	Sirolimus	Sirolimus promotes the reaction [IGF1R protein binds to and results in increased phosphorylation of IRS1 protein]	16227402
C439060	sirtinol	sirtinol results in decreased expression of IGF1R mRNA	22495798
D012906	Smoke	Smoke results in decreased expression of IGF1R mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in increased expression of IGF1R mRNA	21795629
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGF1R mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in increased expression of IGF1R mRNA	17077188
C471405	sorafenib	sorafenib results in decreased expression of IGF1R mRNA	26409325
D013311	Streptozocin	Streptozocin results in decreased expression of IGF1R protein	23562514
D013311	Streptozocin	xanthoceraside inhibits the reaction [Streptozocin results in decreased expression of IGF1R protein]	23562514
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IGF1R mRNA	26378955
D013629	Tamoxifen	Tamoxifen results in increased expression of IGF1R mRNA	21138602
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of IGF1R mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of IGF1R mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of IGF1R mRNA	21045173
D013739	Testosterone	Testosterone results in increased expression of IGF1R mRNA	21703268
D013739	Testosterone	chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]	29247772
D013739	Testosterone	Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]	26492952
D013739	Testosterone	Testosterone results in increased expression of IGF1R mRNA	26492952\|2924777
C004648	testosterone enanthate	testosterone enanthate results in increased expression of IGF1R mRNA	23085480
D043343	Testosterone Propionate	Testosterone Propionate results in increased expression of IGF1R mRNA	23457541
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGF1R mRNA	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGF1R mRNA	17555868\|2290382
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of IGF1R protein	9683191
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of IGF1R mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGF1R mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGF1R mRNA	15034205
D013755	Tetradecanoylphorbol Acetate	corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein]	26513295
D013755	Tetradecanoylphorbol Acetate	maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein]	26513295
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of IGF1R protein	26513295
C020809	tetrathiomolybdate	tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]	18480265
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in decreased expression of IGF1R protein	20931265
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in decreased phosphorylation of IGF1R protein	20931265
D013974	Thyroxine	Thyroxine results in increased expression of IGF1R protein	17447016
D013974	Thyroxine	Vitamin E inhibits the reaction [Thyroxine results in increased expression of IGF1R protein]	17447016
D013974	Thyroxine	Thyroxine results in increased expression of IGF1R mRNA	16764480
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of IGF1R gene	26756918
D014212	Tretinoin	Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF1R mRNA]	21433279
D014212	Tretinoin	Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF1R protein]	21433279
D014212	Tretinoin	Tretinoin results in increased expression of IGF1R protein	21433279
C012589	trichostatin A	trichostatin A results in decreased expression of IGF1R mRNA	28542535
D014260	Triclosan	fulvestrant inhibits the reaction [[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA]	23261820
D014260	Triclosan	[Triclosan co-treated with Ethinyl Estradiol] results in increased expression of IGF1R mRNA	23261820
D014415	Tunicamycin	Tunicamycin results in decreased expression of IGF1R mRNA	17127020
C060152	tyrphostin 47	tyrphostin 47 results in decreased localization of IGF1R protein	9145794
C447031	tyrphostin AG 1024	tyrphostin AG 1024 inhibits the reaction [fulvestrant promotes the reaction [ESR1 protein binds to IGF1R protein]]	19815064
C447031	tyrphostin AG 1024	tyrphostin AG 1024 inhibits the reaction [gefitinib results in increased phosphorylation of IGF1R protein]	17473213
C447031	tyrphostin AG 1024	tyrphostin AG 1024 results in decreased activity of IGF1R protein	22067323
C447031	tyrphostin AG 1024	tyrphostin AG 1024 results in decreased activity of IGF1R protein	19751734
D014527	Uric Acid	IGF1R gene SNP affects the abundance of Uric Acid	23263486
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF1R mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of IGF1R mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of IGF1R mRNA	23179753\|2519280
D014635	Valproic Acid	Valproic Acid results in increased methylation of IGF1R gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of IGF1R mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of IGF1R gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of IGF1R mRNA	23555832
D014810	Vitamin E	Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein]	20015448
D014810	Vitamin E	Vitamin E results in decreased expression of IGF1R mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of IGF1R protein	20015448
D014810	Vitamin E	Vitamin E inhibits the reaction [Thyroxine results in increased expression of IGF1R protein]	17447016
D024483	Vitamin K 3	Vitamin K 3 affects the expression of IGF1R mRNA	20044591
C548611	xanthoceraside	xanthoceraside inhibits the reaction [Streptozocin results in decreased expression of IGF1R protein]	23562514
D015032	Zinc	Zinc promotes the reaction [IGF1 protein binds to IGF1R protein]	9648927
D015032	Zinc	Zinc promotes the reaction [IGF2 protein binds to IGF1R protein]	9648927
D015032	Zinc	Zinc results in decreased expression of IGF1R protein	19913001
D015032	Zinc	Zinc affects the expression of IGF1R mRNA	16413754
D015032	Zinc	Zinc deficiency results in decreased expression of IGF1R mRNA	21893222
D015032	Zinc	Zinc deficiency results in decreased expression of IGF1R protein	21893222
D015032	Zinc	Zinc results in increased phosphorylation of IGF1R protein	14644152
D015034	Zinc Oxide	Zinc Oxide affects the expression of IGF1R mRNA	28648595
D015034	Zinc Oxide	Zinc Oxide affects the expression of IGF1R protein	28648595
D019287	Zinc Sulfate	IGF1R mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]	19946718
D019287	Zinc Sulfate	IGF1R mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]	19946718
D019287	Zinc Sulfate	IGF1R mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]	19946718

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IDA	7679099 11162456
GO:0004713	protein tyrosine kinase activity	-	IMP	11884589
GO:0004713	protein tyrosine kinase activity	-	TAS	-
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005009	insulin-activated receptor activity	-	IBA	21873635
GO:0005010	insulin-like growth factor-activated receptor activity	-	IDA	7679099
GO:0005158	insulin receptor binding	-	IDA	8452530
GO:0005515	protein binding	-	IPI	7541045 7589433 7642582 8452530 8603569 8895367 8999839 9111084 9480911 9506989 9581554 9727029 10026153 11724822 12482592 12556535 14651979 15324660 15629149 15878855 15976035 15998644 16926280 17353931 17360667 20195357 21645859 21685939 22245152 22261717 25241761 25416956 26027733 26692333
GO:0005520	insulin-like growth factor binding	-	IDA	1846292 7679099
GO:0005524	ATP binding	-	IEA	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0031994	insulin-like growth factor I binding	-	IDA	19578119
GO:0031994	insulin-like growth factor I binding	-	IPI	8452530
GO:0042802	identical protein binding	-	IPI	11448933 17586502 21645859
GO:0043548	phosphatidylinositol 3-kinase binding	-	IPI	7541045
GO:0043559	insulin binding	-	IPI	8452530
GO:0043560	insulin receptor substrate binding	-	IBA	21873635
GO:0043560	insulin receptor substrate binding	-	IPI	7541045

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IBA	21873635
GO:0006955	immune response	-	IMP	16886151
GO:0007165	signal transduction	-	TAS	3003744
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IMP	12138094
GO:0008286	insulin receptor signaling pathway	-	ISS	19406747
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0014065	phosphatidylinositol 3-kinase signaling	-	IC	7541045
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030335	positive regulation of cell migration	-	IMP	12138094
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IMP	19545541
GO:0042593	glucose homeostasis	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IDA	12556535
GO:0043243	positive regulation of protein complex disassembly	-	ISS	19406747
GO:0046328	regulation of JNK cascade	-	IDA	12556535
GO:0046777	protein autophosphorylation	-	IDA	1846292 7679099 11162456
GO:0048009	insulin-like growth factor receptor signaling pathway	-	IDA	7679099
GO:0048015	phosphatidylinositol-mediated signaling	-	IDA	7692086
GO:0051262	protein tetramerization	-	IDA	1846292
GO:0051389	inactivation of MAPKK activity	-	IDA	12556535
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0097062	dendritic spine maintenance	-	ISS	19406747
GO:0097242	amyloid-beta clearance	-	IMP	19406747
GO:1904646	cellular response to amyloid-beta	-	IGI	22635104

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IC	7679099
GO:0005899	insulin receptor complex	-	IBA	21873635
GO:0016020	membrane	-	IDA	8452530
GO:0030424	axon	-	IBA	21873635
GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	-	IDA	19578119
GO:0043231	intracellular membrane-bounded organelle	-	IDA	8452530
GO:0043235	receptor complex	-	IBA	21873635
GO:0043235	receptor complex	-	IDA	23382219

KEGG ID	KEGG Term
hsa04114	Oocyte meiosis
hsa04144	Endocytosis
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04730	Long-term depression
hsa04914	Progesterone-mediated oocyte maturation
hsa05200	Pathways in cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-2428933	SHC-related events triggered by IGF1R	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25400749	Insulin-like growth factor receptor 1 (IGF1R) expression and survival in non-small cell lung cancer patients: a meta-analysis. (2014)	Zhao S	Int J Clin Exp Pathol
14581353	Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. (2003 Oct 15)	Miller CT	Clin Cancer Res
19330903	Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. (2009 Mar)	Montasser ME	J Hypertens
26346883	Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. (2016 Aug)	Peregud DI	Cell Mol Neurobiol
28956832	Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)	Sharafeldin N	Int J Environ Res Public Health
25118293	Alterations of insulin-like growth factor-1 receptor gene copy number and protein expression are common in non-small cell lung cancer. (2014 Nov)	Tran TN	J Clin Pathol
29160127	The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific. (2017)	Meyer KF	Epigenetics
28592245	In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)	El-Aarag SA	BMC Med Genomics
19530272	Current insights into the pathogenesis of Graves' orbitopathy. (2009 Jun)	Eckstein AK	Horm Metab Res
28130259	Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring. (2017 Apr 1)	Meyer KF	Am J Physiol Lung Cell Mol Physiol
28740455	Insulin-like Growth Factor 1 Receptor Expression in Advanced Non-small-cell Lung Cancer and its Impact on Overall Survival. (2017 Jun)	Humar M	Radiol Oncol