Gene: GPR141

353345
PGR13
G protein-coupled receptor 141
protein-coding
7p14.1
Ensembl:ENSG00000187037 MIM:609045 Vega:OTTHUMG00000102105 UniprotKB:Q7Z602
NC_000007.14
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.805e-1 (AD)  8.720e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1982389chr7:37687349 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VENTX0.766
TLR80.762
CR10.746
TMEM710.73
SIRPB20.728
GAPT0.713
CD300LF0.712
CD1D0.711
CEACAM40.706
CD2260.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH8-0.402
CDH22-0.399
TAC3-0.395
YJEFN3-0.39
ZMAT4-0.39
GNG13-0.389
LRRC73-0.388
PVALB-0.388
TMEM151B-0.387
KCNN2-0.387

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GPR141 mRNA"23195993
C006780bisphenol Abisphenol A results in decreased expression of GPR141 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of GPR141 mRNA25181051
D003033Coal TarCoal Tar results in increased expression of GPR141 mRNA27858113
D019327Copper SulfateCopper Sulfate results in decreased expression of GPR141 mRNA19549813
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GPR141 mRNA25982114
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of GPR141 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GPR141 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPR141 mRNA"25554681
D009532NickelNickel results in decreased expression of GPR141 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of GPR141 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of GPR141 mRNA24236059
D011192Potassium DichromatePotassium Dichromate results in increased expression of GPR141 mRNA23608068
D012834SilverSilver results in increased expression of GPR141 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR141 mRNA26377647
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GPR141 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of GPR141 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25672891A genome-wide association study of periodontitis in a Japanese population. (2015 Apr)Shimizu SJ Dent Res