Gene: CCDC178

374864
C18orf34
coiled-coil domain containing 178
protein-coding
18q12.1
Ensembl:ENSG00000166960 Vega:OTTHUMG00000132279 UniprotKB:Q5BJE1
NC_000018.10
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.966e-1 (AD)  5.286e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17667691chr18:33198122 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs17739703chr18:32943324 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1960.599
RAD10.597
LGALSL0.593
EXOC60.591
TMEM650.59
DLEU70.587
BHLHE220.586
ZNF7110.583
BLOC1S60.581
C16orf470.581

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLIN4-0.416
EYA2-0.389
S100A1-0.387
FAM151A-0.377
FGFRL1-0.374
GPR143-0.374
AKR1C3-0.365
ACSF2-0.363
NFIA-0.363
KLF15-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC178 gene27153756
D001151ArsenicArsenic affects the methylation of CCDC178 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCDC178 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of CCDC178 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCDC178 mRNA24982889
D016572CyclosporineCyclosporine results in increased expression of CCDC178 mRNA20106945
D002945CisplatinCisplatin results in increased expression of CCDC178 mRNA27392435
D007052IbuprofenIbuprofen results in decreased expression of CCDC178 mRNA28201806
C016517indole-3-carbinolindole-3-carbinol affects the expression of CCDC178 mRNA21396975
C568376MT19c compoundMT19c compound results in decreased expression of CCDC178 mRNA21781307

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal