Gene: LHFPL3

375612
LHFPL4
LHFPL tetraspan subfamily member 3
protein-coding
7q22.2-q22.3
Ensembl:ENSG00000187416 MIM:609719 Vega:OTTHUMG00000157273 UniprotKB:Q86UP9
NC_000007.14
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.811e-1 (AD)  6.481e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11761950chr7:104675698 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs10254402chr7:104551951 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA5A0.85
STK32A0.823
BCHE0.805
PDGFRA0.805
BLM0.788
LUZP20.776
TMEM255A0.765
PCDH150.762
B3GNT70.741
CCDC500.734

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.412
OR4F29-0.367
FAM83D-0.353
ADPRHL1-0.343
IL1RL2-0.333
PDF-0.328
SHROOM3-0.328
ROS1-0.328
HUNK-0.317
GDF7-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LHFPL3 gene27153756
C015001arsenitearsenite results in decreased methylation of LHFPL3 promoter23974009
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LHFPL3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LHFPL3 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LHFPL3 mRNA27858113
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHFPL3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of LHFPL3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of LHFPL3 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LHFPL3 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of LHFPL3 mRNA27858113
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LHFPL3 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHFPL3 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in decreased expression of LHFPL3 mRNA23656968
D004147DioxinsDioxins affects the expression of LHFPL3 mRNA20463971
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHFPL3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHFPL3 mRNA28628672
C008261lead acetatelead acetate results in decreased expression of LHFPL3 mRNA22613225
C045463leflunomideleflunomide results in increased expression of LHFPL3 mRNA19751817
D012999SomanSoman results in increased expression of LHFPL3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LHFPL3 mRNA21354282
D014635Valproic AcidValproic Acid results in increased methylation of LHFPL3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal