Gene: KIF11

3832
EG5|HKSP|KNSL1|MCLMR|TRIP5
kinesin family member 11
protein-coding
10q23.33
Ensembl:ENSG00000138160 MIM:148760 Vega:OTTHUMG00000018761 UniprotKB:P52732
NG_032580.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.181e-1 (AD)  9.090e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6583832chr10:92641615 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETDB20.796
FAM161A0.758
MAD2L10.757
FAM160B10.756
GNPDA20.755
ORC30.754
RMDN20.752
GTF2A10.749
GPALPP10.747
CUL4B0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBXA2R-0.379
NKX6-1-0.373
KLRB1-0.372
MTRNR2L9-0.362
PGF-0.356
MTRNR2L10-0.355
MTRNR2L6-0.344
C1QTNF1-0.332
PLA2G5-0.326
CLIC3-0.323

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB039963-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]PhenolSmall MoleculeExperimentalTarget
DB04331MonastrolSmall MoleculeExperimentalTarget
DB06040FilanesibSmall Molecule885060-09-3InvestigationalTarget
DB07064(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDESmall MoleculeExperimentalTarget
DB08032N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESmall MoleculeExperimentalTarget
DB08033(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESmall MoleculeExperimentalTarget
DB08037(2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamideSmall MoleculeExperimentalTarget
DB08198[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONESmall MoleculeExperimentalTarget
DB08239(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDESmall MoleculeExperimentalTarget
DB08244(1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINESmall MoleculeExperimentalTarget
DB08246(2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDESmall MoleculeExperimentalTarget
DB08250(5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of KIF11 mRNA"28903501
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of KIF11 mRNA"19414516
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of KIF11 mRNA"19167446
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of KIF11 mRNA25088246
C0037243-tritylthio-L-alanine3-tritylthio-L-alanine binds to and results in decreased activity of KIF11 protein21344920
C5309524-(2,5-difluorophenyl)-N-(3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide"4-(2,5-difluorophenyl)-N-(3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide results in decreased activity of KIF11 protein"21344920|2189929
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of KIF11 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KIF11 protein modified form]"28751236
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of KIF11 mRNA19191707
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of KIF11 mRNA"19936915
C1197378-prenylnaringenin8-prenylnaringenin results in increased expression of KIF11 mRNA26372666
C1197378-prenylnaringeninMethylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA]26372666
D000082AcetaminophenAcetaminophen results in decreased expression of KIF11 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of KIF11 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KIF11 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of KIF11 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KIF11 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of KIF11 mRNA"22863853
D001280AtrazineAtrazine results in increased expression of KIF11 mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of KIF11 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of KIF11 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KIF11 mRNA20064835|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIF11 mRNA"19150397|2038263
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA24657404
D004958EstradiolEstradiol results in increased expression of KIF11 mRNA16474171|1916744
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of KIF11 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of KIF11 mRNA25210133
D004958EstradiolEstradiol results in increased expression of KIF11 mRNA26372666
C006780bisphenol Abisphenol A affects the expression of KIF11 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of KIF11 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of KIF11 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of KIF11 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of KIF11 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of KIF11 mRNA26079696
D002104CadmiumCadmium results in decreased expression of KIF11 mRNA21120746
D002211CapsaicinCapsaicin results in increased expression of KIF11 mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KIF11 mRNA17484886
C035377chlorendic acidchlorendic acid results in increased expression of KIF11 mRNA22584684
D004390ChlorpyrifosChlorpyrifos results in decreased expression of KIF11 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of KIF11 mRNA21356183
C487201CK0106023CK0106023 results in decreased activity of KIF11 protein21899292
C018021cobaltous chloridecobaltous chloride results in decreased expression of KIF11 mRNA19376846
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of KIF11 mRNA21356183
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of KIF11 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of KIF11 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of KIF11 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of KIF11 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of KIF11 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of KIF11 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of KIF11 mRNA20106945|2163298
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to KIF11 protein modified form]28751236
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KIF11 mRNA24317228
C014347decitabinedecitabine affects the expression of KIF11 mRNA23300844
D002945CisplatinCisplatin affects the expression of KIF11 mRNA23300844
D002945CisplatinCisplatin affects the reaction [Piroxicam results in decreased expression of KIF11 mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of KIF11 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of KIF11 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of KIF11 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of KIF11 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of KIF11 mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of KIF11 mRNA20920545
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KIF11 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF11 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of KIF11 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of KIF11 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of KIF11 mRNA26924002
D004147DioxinsDioxins affects the expression of KIF11 mRNA20463971
C544550filanesibfilanesib results in decreased activity of KIF11 protein21899292
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of KIF11 mRNA22584684
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of KIF11 mRNA24657277
C039281furanfuran results in increased expression of KIF11 mRNA25539665
D019833GenisteinGenistein results in increased expression of KIF11 mRNA16474171
D005944GlucosamineGlucosamine results in decreased expression of KIF11 mRNA17109745
C005010harmanharman results in decreased activity of KIF11 protein21599002
D006247HarmineHarmine results in decreased activity of KIF11 protein21599002
C483533HR22C16HR22C16 analog results in decreased activity of KIF11 protein21899292
C483533HR22C16HR22C16 results in decreased activity of KIF11 protein21599002
C492448ICG 001ICG 001 results in decreased expression of KIF11 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of KIF11 mRNA25613284
C508757ispinesibispinesib results in decreased activity of KIF11 protein21899292
C410337K 7174K 7174 results in decreased expression of KIF11 mRNA24086573
D007649KetamineKetamine results in decreased expression of KIF11 mRNA20080153
D007854LeadLead affects the expression of KIF11 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of KIF11 mRNA20542052
C008261lead acetatelead acetate results in increased expression of KIF11 mRNA22609695
C045463leflunomideleflunomide results in decreased expression of KIF11 mRNA28988120
D008154LucanthoneLucanthone results in decreased expression of KIF11 mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KIF11 mRNA21641980
D008701MethapyrileneMethapyrilene results in increased expression of KIF11 mRNA22584684
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of KIF11 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of KIF11 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of KIF11 mRNA20713471
D008748MethylcholanthreneMethylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA]26372666
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KIF11 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of KIF11 mRNA24810058
C008493methylselenic acidmethylselenic acid results in decreased expression of KIF11 mRNA12517777
C400223monastrolmonastrol results in decreased activity of KIF11 protein21344920
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KIF11 mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of KIF11 mRNA25102026
C568512N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide"N-(3-aminopropyl)-N-(1-(5-benzyl-3-methyl-4-oxo-(1,2)thiazolo(5,4-d)pyrimidin-6-yl)-2-methylpropyl)-4-methylbenzamide results in decreased activity of KIF11 protein"21899292
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KIF11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KIF11 mRNA"25554681
C008661nobiletinnobiletin results in decreased expression of KIF11 mRNA23321314
C008661nobiletinnobiletin results in decreased expression of KIF11 mRNA23321314
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of KIF11 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KIF11 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of KIF11 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of KIF11 mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of KIF11 mRNA25658374
D010126OzoneOzone results in increased expression of KIF11 mRNA25658374
C500026palbociclibpalbociclib results in decreased expression of KIF11 mRNA22869556
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of KIF11 mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of KIF11 mRNA23091169
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in decreased expression of KIF11 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of KIF11 mRNA21858171
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of KIF11 mRNA16474171
D011192Potassium DichromatePotassium Dichromate results in decreased expression of KIF11 mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of KIF11 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of KIF11 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of KIF11 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of KIF11 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of KIF11 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of KIF11 mRNA15767336|1808983
C059514resveratrolresveratrol results in decreased expression of KIF11 protein18089832
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of KIF11 mRNA]21852083
C557279SB 743921SB 743921 results in decreased activity of KIF11 protein21899292
C410733scriptaidscriptaid affects the expression of KIF11 mRNA18813790
C017947sodium arsenitesodium arsenite results in decreased expression of KIF11 mRNA17998272
D053260SootSoot results in increased expression of KIF11 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KIF11 mRNA21641980
C477863terpendole Eterpendole E results in decreased activity of KIF11 protein21599002
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of KIF11 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of KIF11 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIF11 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KIF11 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of KIF11 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of KIF11 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of KIF11 protein24648495
D013853ThioacetamideThioacetamide results in increased expression of KIF11 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of KIF11 mRNA24023007
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KIF11 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KIF11 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of KIF11 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of KIF11 mRNA"17951470
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of KIF11 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KIF11 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KIF11 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of KIF11 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of KIF11 mRNA28001369
D014747VinblastineKIF11 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in increased expression of KIF11 mRNA21126777
C025643vinclozolinvinclozolin results in decreased expression of KIF11 mRNA20566332
C029297vinylidene chloridevinylidene chloride results in increased expression of KIF11 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IBA21873635  
GO:0003777microtubule motor activity-TAS8548803  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0008574ATP-dependent microtubule motor activity, plus-end-directed-IBA21873635  
GO:0016887ATPase activity-IBA21873635  
GO:0019901protein kinase binding-IPI19001501  
GO:0044877protein-containing complex binding-IDA17707232  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-TAS8548803  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-TAS-  
GO:0007018microtubule-based movement-IBA21873635  
GO:0007018microtubule-based movement-TAS-  
GO:0007051spindle organization-IMP14718566  
GO:0007052mitotic spindle organization-TAS8548803  
GO:0007100mitotic centrosome separation-IEA-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0046602regulation of mitotic centrosome separation-IMP15843429  
GO:0051301cell division-IEA-  
GO:0090307mitotic spindle assembly-IBA21873635  
GO:0090307mitotic spindle assembly-IDA19001501  
GO:0090307mitotic spindle assembly-IMP15843429  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle polecolocalizes_withIDA14718566  
GO:0005634nucleus-IBA21873635  
GO:0005819spindle-IDA19001501  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005871kinesin complex-IBA21873635  
GO:0005871kinesin complex-TAS8548803  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IDA21525035  
GO:0005876spindle microtubule-IBA21873635  
GO:0005876spindle microtubulecolocalizes_withIDA14718566  
GO:0016020membrane-HDA19946888  
GO:0072686mitotic spindle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal