Gene info: ID 389432

Gene: SAMD5

GENE ID: 389432

Synonyms: dJ875H10.1

Description: sterile alpha motif domain containing 5

Gene type: protein-coding

Location: 6q24.3

dbXrefs: Ensembl:ENSG00000203727 Vega:OTTHUMG00000015767 UniprotKB:Q5TGI4

RefSeq: NC_000006.12

Retrived from: SNP Mapped

SNPs: 13 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.226e-1 (AD) 2.344e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs9322108	chr6:147724045 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs844604	chr6:147603319 (GRCh38.p7)	T>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs702354	chr6:147601419 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs844613	chr6:147597446 (GRCh38.p7)	G>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs1944645	chr6:147594330 (GRCh38.p7)	A>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs844577	chr6:147592924 (GRCh38.p7)	A>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs844574	chr6:147591579 (GRCh38.p7)	A>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs844568	chr6:147591295 (GRCh38.p7)	G>A / G>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs844563	chr6:147588032 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs844562	chr6:147587859 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs702353	chr6:147585618 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs844557	chr6:147585145 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs844625	chr6:147578081 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNK2	0.856
NTN4	0.842
RAB3B	0.838
ARHGAP20	0.827
PLCXD3	0.822
SPHKAP	0.819
CHRM2	0.819
XKR4	0.815
VWC2L	0.802
EPHA5	0.801

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
STON2	-0.573
PHF21B	-0.566
IMPA2	-0.556
RFX4	-0.545
NBPF10	-0.544
FXYD3	-0.544
FGF11	-0.535
HVCN1	-0.529
NFATC1	-0.522
PARD3	-0.52

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of SAMD5 mRNA"	26377693
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD5 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SAMD5 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SAMD5 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SAMD5 mRNA	22100608
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SAMD5 mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SAMD5 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to SAMD5 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SAMD5 mRNA	21569818
D004958	Estradiol	Estradiol results in increased expression of SAMD5 mRNA	20106945
C006780	bisphenol A	bisphenol A results in decreased expression of SAMD5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SAMD5 gene	28505145
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SAMD5 mRNA	28472532
D003471	Cuprizone	Cuprizone results in decreased expression of SAMD5 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of SAMD5 mRNA	20106945
C014347	decitabine	decitabine results in decreased expression of SAMD5 mRNA	19363521
C014347	decitabine	TP53 protein affects the reaction [decitabine results in decreased expression of SAMD5 mRNA]	19363521
D004041	Dietary Fats	Dietary Fats results in decreased expression of SAMD5 mRNA	25016146
C001277	geldanamycin	geldanamycin results in increased expression of SAMD5 mRNA	26705709
D017313	Fenretinide	Fenretinide results in increased expression of SAMD5 mRNA	28973697
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of SAMD5 mRNA	26667767
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SAMD5 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SAMD5 mRNA"	25554681\|2562005
D009532	Nickel	Nickel results in decreased expression of SAMD5 mRNA	24768652\|2558310
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SAMD5 mRNA	26272509
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SAMD5 mRNA	24780913
C059514	resveratrol	[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of SAMD5 mRNA	26667767
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of SAMD5 mRNA	23806026
D012906	Smoke	Smoke results in increased expression of SAMD5 mRNA	20015843
D053260	Soot	Soot results in decreased expression of SAMD5 mRNA	26551751
D013629	Tamoxifen	Tamoxifen results in increased expression of SAMD5 mRNA	25123088
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of SAMD5 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SAMD5 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SAMD5 mRNA	21354282
C009495	titanium dioxide	titanium dioxide results in increased expression of SAMD5 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SAMD5 mRNA	28065790
D014212	Tretinoin	Tretinoin results in increased expression of SAMD5 mRNA	21934132
D014635	Valproic Acid	Valproic Acid affects the expression of SAMD5 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SAMD5 mRNA	23179753\|2800136
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of SAMD5 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of SAMD5 mRNA	23869203
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SAMD5 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of SAMD5 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0009966	regulation of signal transduction	-	IBA	21873635
GO:0043507	positive regulation of JUN kinase activity	-	IBA	21873635
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal