Gene: IYD

389434
C6orf71|DEHAL1|IYD-1|TDH4
iodotyrosine deiodinase
protein-coding
6q25.1
Ensembl:ENSG00000009765 MIM:612025 Vega:OTTHUMG00000016347 UniprotKB:Q6PHW0
NG_016007.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.062e-1 (AD)  2.725e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13197942chr6:150404961 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPO0.969
FOXE10.943
TG0.919
SLC26A70.851
TFF30.85
KRT70.829
WDR720.805
DIO10.777
SCNN1B0.767
TSHR0.76

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BOLA1-0.385
C3orf18-0.38
HDDC3-0.379
SPAG8-0.375
TMEM53-0.374
ZNF575-0.367
HDAC11-0.365
HHATL-0.364
TM7SF2-0.362
PAQR4-0.362

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB033743,5-DiiodotyrosineSmall Molecule300-39-0ExperimentalTarget
ID Drug Name Action PubMed
C5726252,2',4,5'-tetrabromodiphenyl ether"2,2',4,5'-tetrabromodiphenyl ether analog results in decreased activity of IYD protein"24012475
D000082AcetaminophenAcetaminophen results in decreased expression of IYD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of IYD mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of IYD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IYD mRNA27153756
C547126AZM551248AZM551248 results in decreased expression of IYD mRNA22323515
D001553BenzbromaroneBenzbromarone results in decreased activity of IYD protein24012475
C006780bisphenol Abisphenol A results in decreased expression of IYD mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IYD gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of IYD mRNA27339419
D016572CyclosporineCyclosporine results in decreased expression of IYD mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of IYD mRNA19770486
D002117CalcitriolCalcitriol results in increased expression of IYD mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of IYD mRNA21592394
D010697Eosine I BluishEosine I Bluish results in decreased activity of IYD protein24012475
D004923ErythrosineErythrosine results in decreased activity of IYD protein24012475
D005485FlutamideFlutamide results in decreased expression of IYD mRNA24136188|2479361
D005897GlafenineGlafenine results in decreased expression of IYD mRNA24136188
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers analog results in decreased activity of IYD protein24012475
D017313FenretinideFenretinide results in increased expression of IYD mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IYD mRNA26752646
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IYD mRNA23103053
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of IYD mRNA25380136
C051752nefazodonenefazodone results in decreased expression of IYD mRNA24136188
C012655nimesulidenimesulide results in decreased expression of IYD mRNA24136188
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased activity of IYD protein24012475
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IYD mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of IYD mRNA23557933
D011075Polybrominated BiphenylsPolybrominated Biphenyls analog results in decreased activity of IYD protein24012475
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased activity of IYD protein24012475
D011374ProgesteroneProgesterone results in increased expression of IYD mRNA19690047
D012395Rose BengalRose Bengal results in decreased activity of IYD protein24012475
C089730rosiglitazonerosiglitazone results in decreased expression of IYD mRNA25572481
D014284TriiodothyronineTriiodothyronine results in increased expression of IYD mRNA19228888
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of IYD mRNA21592394
D013739TestosteroneTestosterone results in increased expression of IYD mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IYD mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IYD mRNA21215274
D014260TriclosanTriclosan results in decreased activity of IYD protein24012475
D014635Valproic AcidValproic Acid affects the expression of IYD mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IYD gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of IYD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004447iodide peroxidase activity-IBA21873635  
GO:0004447iodide peroxidase activity-IEA-  
GO:0005515protein binding-IPI25416956  25910212  
GO:0010181FMN binding-IDA25395621  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0016491oxidoreductase activity-IDA25395621  
GO:0016491oxidoreductase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006570tyrosine metabolic process-IBA21873635  
GO:0006570tyrosine metabolic process-IDA25395621  
GO:0006590thyroid hormone generation-TAS-  
GO:0042403thyroid hormone metabolic process-IBA21873635  
GO:0042403thyroid hormone metabolic process-IDA25395621  
GO:0055114oxidation-reduction process-IDA25395621  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA15289438  
GO:0030659cytoplasmic vesicle membrane-IDA15289438  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209968Thyroxine biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal