Gene: OR10A6

390093
OR11-96
olfactory receptor family 10 subfamily A member 6 (gene/pseudogene)
protein-coding
11p15.4
Ensembl:ENSG00000279000 UniprotKB:Q8NH74
NC_000011.10
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.605e-4 (AD)  2.720e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7928451chr11:7928313 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7933807chr11:7928244 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPN1MW0.78
POM121L120.688
OR2W50.684
TAAR20.673
TRIM400.667
BPIFB30.648
ACTBL20.644
OR2B30.635
RFPL4AL10.634
UGT2A30.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH20-0.294
MYBPC1-0.293
LRTOMT-0.287
PEX11A-0.277
CTDSPL-0.265
CCDC153-0.254
MARC1-0.25
IGSF11-0.246
CAMKMT-0.246
ADARB2-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OR10A6 gene27153756
D014635Valproic AcidValproic Acid results in decreased methylation of OR10A6 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0004984olfactory receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0050911detection of chemical stimulus involved in sensory perception of smell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-381753Olfactory Signaling PathwayTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal