Gene: LAMA2

3908
LAMM
laminin subunit alpha 2
protein-coding
6q22.33
Ensembl:ENSG00000196569 MIM:156225 Vega:OTTHUMG00000015545 UniprotKB:P24043
NG_008678.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.068e-1 (AD)  5.406e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2571577chr6:129476939 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4895846chr6:129063222 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4534007chr6:129052544 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RECK0.646
TAF10.64
CD460.634
ATP11B0.618
DOCK90.618
RBM250.617
TACC10.617
ZKSCAN10.614
PTPRB0.611
NID20.611

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7B-0.358
OR4F29-0.333
OR4F5-0.316
BTBD17-0.304
SLC22A6-0.304
HES5-0.298
CIB3-0.292
DAND5-0.286
ROPN1B-0.282
HMX1-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of LAMA2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of LAMA2 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA2 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of LAMA2 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA2 mRNA"27188386
C103303alitretinoinalitretinoin results in decreased expression of LAMA2 mRNA15982314
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LAMA2 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of LAMA2 mRNA24489787
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of LAMA2 mRNA18585445
D001152ArsenicalsArsenicals results in increased methylation of LAMA2 promoter26039340
C015001arsenitearsenite results in increased methylation of LAMA2 promoter23974009
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of LAMA2 mRNA18585445
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of LAMA2 mRNA26377693
D004958EstradiolEstradiol results in increased expression of LAMA2 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of LAMA2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of LAMA2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of LAMA2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LAMA2 mRNA17484886
D002509CephaloridineCephaloridine results in decreased expression of LAMA2 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAMA2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of LAMA2 protein28596144
D003471CuprizoneCuprizone results in increased expression of LAMA2 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LAMA2 mRNA24317228
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LAMA2 mRNA21266533
D002945CisplatinLAMA2 mRNA results in increased susceptibility to Cisplatin25199881
D002117CalcitriolCalcitriol results in decreased expression of LAMA2 mRNA26485663
D004237DiuronDiuron results in decreased expression of LAMA2 mRNA25152437
D004317DoxorubicinLAMA2 mRNA results in increased susceptibility to Doxorubicin25199881
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LAMA2 mRNA17557909
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of LAMA2 gene16724327
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAMA2 mRNA20938992
D004397FonofosFonofos results in increased methylation of LAMA2 promoter22847954
D017313FenretinideFenretinide results in decreased expression of LAMA2 mRNA28973697
D007545IsoproterenolIsoproterenol results in decreased expression of LAMA218808529
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LAMA2 mRNA26752646
C008261lead acetatelead acetate results in increased expression of LAMA2 mRNA22609695
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LAMA2 mRNA20938992
D008727MethotrexateLAMA2 mRNA results in increased susceptibility to Methotrexate25199881
D015735MifepristoneMifepristone results in decreased expression of LAMA2 mRNA17584828
D008942MitoxantroneLAMA2 mRNA affects the susceptibility to Mitoxantrone16044152
D009151Mustard GasMustard Gas results in decreased expression of LAMA2 mRNA15674843
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of LAMA2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LAMA2 mRNA"25554681
D009532NickelNickel results in decreased expression of LAMA2 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of LAMA2 mRNA27935865
D017239PaclitaxelLAMA2 mRNA results in increased susceptibility to Paclitaxel25199881
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of LAMA2 mRNA26272509
D010278ParathionParathion results in increased methylation of LAMA2 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of LAMA2 mRNA26705709
D010672PhenytoinPhenytoin results in increased expression of LAMA2 mRNA20345932
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of LAMA2 mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in decreased expression of LAMA2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of LAMA2 mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of LAMA2 mRNA26079696
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of LAMA2 mRNA23274088
C043680ptaquilosideptaquiloside results in decreased expression of LAMA2 mRNA23274088
C502851quinocetonequinocetone results in increased expression of LAMA2 mRNA27046791
D015474IsotretinoinIsotretinoin results in decreased expression of LAMA2 mRNA15982314
D015474IsotretinoinIsotretinoin results in increased expression of LAMA2 mRNA20436886
D012715Sesame OilSesame Oil results in increased expression of LAMA2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LAMA2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LAMA2 mRNA22431001
C009277sodium arsenatesodium arsenate results in increased expression of LAMA2 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of LAMA2 gene28589171
C016104sodium bichromatesodium bichromate affects the expression of LAMA2 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in decreased expression of LAMA2 protein28918527
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of LAMA2 mRNA23274088
D018038Sodium SeleniteSodium Selenite results in decreased expression of LAMA2 mRNA23274088
C012568terbufosterbufos results in increased methylation of LAMA2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LAMA2 mRNA17586704
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LAMA2 mRNA27865774
D019772TopotecanLAMA2 mRNA results in increased susceptibility to Topotecan25199881
D014118Toxins, Biological"Toxins, Biological affects the expression of LAMA2 mRNA"19682533
D014212TretinoinTretinoin metabolite results in decreased expression of LAMA2 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of LAMA2 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of LAMA2 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of LAMA2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LAMA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LAMA2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LAMA2 gene25560391
D014750VincristineLAMA2 mRNA results in increased susceptibility to Vincristine25199881

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO:0005198structural molecule activity-TAS2185464  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007411axon guidance-IEA-  
GO:0007517muscle organ development-TAS7550355  
GO:0014037Schwann cell differentiation-IEA-  
GO:0030155regulation of cell adhesion-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030334regulation of cell migration-IEA-  
GO:0032224positive regulation of synaptic transmission, cholinergic-IEA-  
GO:0045995regulation of embryonic development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IDA2099832  14557481  
GO:0005605basal lamina-IEA-  
GO:0042383sarcolemma-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3000178ECM proteoglycansIEA
R-HSA-6806834Signaling by METTAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal