Gene: SULT6B1

391365
-
sulfotransferase family 6B member 1
protein-coding
2p22.2
Ensembl:ENSG00000138068 MIM:617152 Vega:OTTHUMG00000152160 UniprotKB:Q6IMI4
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.523e-1 (AD)  9.967e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11895771chr2:37185792 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SELP0.501
OR52Z10.468
C16orf780.466
OR6Q10.465
C17orf980.437
OR10H20.436
STEAP40.428
SLC6A140.423
OR1J10.421
OR52M10.416

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF2-0.24
NHLRC4-0.21
ASPDH-0.208
TSPAN16-0.2
NXPH3-0.198
HES6-0.193
MDGA1-0.192
HHATL-0.189
LHX2-0.187
TMIE-0.187

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of SULT6B1 mRNA"24375616
C0553831,3,5-tribromobenzene"1,3,5-tribromobenzene analog results in decreased expression of SULT6B1 mRNA"26318274
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether metabolite results in decreased expression of SULT6B1 mRNA"26318274
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of SULT6B1 mRNA"26318274
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SULT6B1 mRNA"28973690
C0776467,12-benz(a)anthraquinone"7,12-benz(a)anthraquinone results in increased expression of SULT6B1 mRNA"26141390
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SULT6B1 gene27153756
D001151ArsenicArsenic affects the methylation of SULT6B1 gene25304211
D001280AtrazineAtrazine results in decreased expression of SULT6B1 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of SULT6B1 mRNA23656968
C012768benzanthronebenzanthrone results in increased expression of SULT6B1 mRNA26141390
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SULT6B1 mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of SULT6B1 mRNA24214726
C006780bisphenol Abisphenol A results in decreased expression of SULT6B1 mRNA25181051
D002104CadmiumCadmium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SULT6B1 protein]29107029
C061365flusilazoleflusilazole results in increased expression of SULT6B1 mRNA22382673
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SULT6B1 mRNA26846883
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SULT6B1 mRNA26011545
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SULT6B1 protein19474218
D011441PropylthiouracilPropylthiouracil results in decreased expression of SULT6B1 mRNA24780913
C009277sodium arsenatesodium arsenate results in increased expression of SULT6B1 mRNA23922661
D013749TetrachlorodibenzodioxinCadmium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SULT6B1 protein]29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT6B1 mRNA16443690|1671440
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SULT6B1 protein29107029
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of SULT6B1 mRNA"22055752

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004062aryl sulfotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal