Gene: OR1L6

392390
HG16|OR1K1|OR1L7|OR9-30
olfactory receptor family 1 subfamily L member 6
protein-coding
9q33.2
Ensembl:ENSG00000171459 Vega:OTTHUMG00000020621 UniprotKB:Q8NGR2
NG_034003.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.380e-1 (AD)  3.255e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10985760chr9:122750491 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF110.505
MMP120.499
CPA60.495
KRTAP19-50.491
PATE10.47
HIST1H2BA0.467
OR5T30.464
OR5L20.464
OR11G20.461
CSH10.451

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK7-0.21
MYADML2-0.201
GTDC1-0.199
ZNF488-0.191
DNAJC28-0.19
MUM1L1-0.183
SPRR2E-0.181
ATP6V1E2-0.181
SNAP25-AS1-0.177
C5orf52-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of OR1L6 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of OR1L6 mRNA25181051

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0050911detection of chemical stimulus involved in sensory perception of smell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-381753Olfactory Signaling PathwayTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal