Gene: CCSER1

401145
FAM190A
coiled-coil serine rich protein 1
protein-coding
4q22.1
Ensembl:ENSG00000184305 Vega:OTTHUMG00000160950 UniprotKB:Q9C0I3
NC_000004.12
PubMed|SNP Mapped
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.261e-1 (AD)  1.875e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13134142chr4:90721760 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs62313897chr4:90215590 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH70.815
PCLO0.804
ZNF910.798
NYAP20.797
GRIN2A0.789
SETBP10.782
CSMD30.777
NBEA0.776
SLC8A10.775
SCAI0.768

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGTRAP-0.523
ROM1-0.522
RAB13-0.515
CSAG1-0.508
COPZ2-0.479
VAMP5-0.472
RHOD-0.47
SERTAD3-0.469
FLT3LG-0.468
SNHG18-0.466

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCSER1 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCSER1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCSER1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCSER1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CCSER1 mRNA24449571
D001151ArsenicArsenic affects the methylation of CCSER1 gene25304211
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CCSER1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CCSER1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CCSER1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CCSER1 gene28505145
D003042CocaineCCSER1 gene SNP affects the susceptibility to Cocaine18438686
D003471CuprizoneCuprizone results in decreased expression of CCSER1 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CCSER1 mRNA24317228
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CCSER1 mRNA28329830
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CCSER1 mRNA"25554681
D013849ThimerosalThimerosal results in increased expression of CCSER1 mRNA27188386
D014212TretinoinTretinoin results in increased expression of CCSER1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of CCSER1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCSER1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of CCSER1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CCSER1 mRNA26272509
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CCSER1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of CCSER1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28990359Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. (2017 Dec)Polimanti RAm J Med Genet B Neuropsychiatr Genet