Gene: CENPP

401541
CENP-P
centromere protein P
protein-coding
9q22.31
Ensembl:ENSG00000188312 MIM:611505 Vega:OTTHUMG00000020228 UniprotKB:Q6IPU0
NC_000009.12
SNP Mapped
2   ANCO-SNPs
AD
0   
8.977e-1 (AD)  8.548e-1 (ND)   (Frontal_Cortex)
9.398e-1 (AD)  9.592e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10820978chr9:92458319 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10820967chr9:92339447 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEATR5B0.801
ODF2L0.796
RASAL20.793
ATG2B0.79
RFC50.789
TGFBRAP10.786
TBC1D300.786
TOPBP10.785
MTMR40.784
PRDM100.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.448
AQP5-0.395
COPZ2-0.394
RAB13-0.376
AKR1C3-0.373
HEY2-0.37
FAM181A-0.368
TRDN-0.366
RBP1-0.364
PLA2G5-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CENPP mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPP mRNA"25510870
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CENPP protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CENPP protein]26598702
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CENPP mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CENPP gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CENPP mRNA19770486
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CENPP protein]26598702
D001280AtrazineAtrazine results in increased expression of CENPP mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CENPP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CENPP mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CENPP mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CENPP mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of CENPP mRNA23798566
C006780bisphenol Abisphenol A affects the expression of CENPP mRNA21786754
C018475butyraldehydebutyraldehyde results in decreased expression of CENPP mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CENPP mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CENPP mRNA17484886
C018021cobaltous chloridecobaltous chloride results in increased expression of CENPP mRNA24386269
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CENPP mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of CENPP mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CENPP mRNA24535843
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CENPP mRNA22079256
D007213IndomethacinIndomethacin results in decreased expression of CENPP mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CENPP mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CENPP mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CENPP mRNA20061341
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CENPP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CENPP mRNA"25554681
D010100OxygenOxygen deficiency results in decreased expression of CENPP mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CENPP mRNA"25510870
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CENPP mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CENPP mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CENPP mRNA19482888|2309116
C006253pirinixic acidpirinixic acid results in increased expression of CENPP mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CENPP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CENPP mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CENPP mRNA22698814
C005556propionaldehydepropionaldehyde results in decreased expression of CENPP mRNA26079696
D012969Sodium FluorideSodium Fluoride results in decreased expression of CENPP mRNA27862939
D053260SootSoot results in increased expression of CENPP mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CENPP mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CENPP mRNA25613284
D014212TretinoinTretinoin results in decreased expression of CENPP mRNA20530235
D014212TretinoinTretinoin results in decreased expression of CENPP mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased expression of CENPP mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CENPP mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CENPP gene25560391
C025643vinclozolinvinclozolin results in increased expression of CENPP mRNA23869203
C029297vinylidene chloridevinylidene chloride results in increased expression of CENPP mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0034080CENP-A containing nucleosome assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IEA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromereTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-774815Nucleosome assemblyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal