Gene: VWC2L

402117
-
von Willebrand factor C domain containing protein 2 like
protein-coding
2q34-q35
Ensembl:ENSG00000174453 Vega:OTTHUMG00000154811 UniprotKB:B2RUY7
NC_000002.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.843e-1 (AD)  9.097e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9288497chr2:214505328 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4629153chr2:214492214 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs13425618chr2:214485443 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLRT30.93
FAM102B0.923
TRHDE0.914
PLCXD30.911
EPHA50.91
ELAVL20.902
ZNF385B0.9
LSM110.9
STAMBPL10.897
CDK140.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.583
RAB13-0.56
RNF135-0.558
REST-0.538
RHOD-0.538
TRIP6-0.538
GPRC5C-0.537
IMPA2-0.533
AGTRAP-0.533
ASB4-0.531

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of VWC2L mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of VWC2L mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of VWC2L mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of VWC2L mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of VWC2L mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of VWC2L mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of VWC2L gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of VWC2L mRNA21757418
D001280AtrazineAtrazine results in decreased expression of VWC2L mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of VWC2L mRNA22323515
C006780bisphenol Abisphenol A results in increased methylation of VWC2L gene28505145
C008261lead acetatelead acetate results in decreased expression of VWC2L mRNA22641619
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of VWC2L mRNA"20188158
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of VWC2L mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in increased expression of VWC2L mRNA24780913
D014635Valproic AcidValproic Acid results in decreased methylation of VWC2L gene29154799
D014635Valproic AcidValproic Acid affects the expression of VWC2L mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of VWC2L gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0030514negative regulation of BMP signaling pathway-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0030054cell junction-IEA-  
GO:0032281AMPA glutamate receptor complex-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal