Gene: MEA1

4201
HYS|MEA
male-enhanced antigen 1
protein-coding
6p21.1
Ensembl:ENSG00000124733 MIM:143170 Vega:OTTHUMG00000014717 UniprotKB:Q16626
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.937e-1 (AD)  6.288e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3793023chr6:43015021 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEDD80.975
UQCRH0.975
MRPS210.965
PRDX50.965
NABP20.963
ATP6V1F0.962
NHP20.96
TPI10.96
NDUFA80.958
PDAP10.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.803
OR4F29-0.773
CXCR2-0.319
KCNJ15-0.309
IL18RAP-0.308
MTRNR2L6-0.302
VNN3-0.298
CXCR1-0.293
P2RY14-0.285
FCGR3B-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MEA1 mRNA"28712647
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MEA1 mRNA"19167446
D001280AtrazineAtrazine results in decreased expression of MEA1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of MEA1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MEA1 mRNA20504355|2222880
C006780bisphenol Abisphenol A results in increased expression of MEA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MEA1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MEA1 mRNA28628672
D019327Copper SulfateCopper Sulfate results in decreased expression of MEA1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MEA1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of MEA1 mRNA19167446
C009160cyclonitecyclonite results in decreased expression of MEA1 mRNA20965580
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MEA1 mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MEA1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MEA1 mRNA17942748
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MEA1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MEA1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MEA1 mRNA28628672
C544151jinfukangjinfukang results in increased expression of MEA1 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MEA1 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MEA1 mRNA23649840
C006253pirinixic acidpirinixic acid results in increased expression of MEA1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of MEA1 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEA1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MEA1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MEA1 mRNA25613284
D014050TolueneToluene results in decreased expression of MEA1 mRNA22967744
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MEA1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  
GO ID GO Term Qualifier Evidence PubMed
GO:0007283spermatogenesis-IEA-  
GO:0008584male gonad development-TAS2813404  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal