Gene: MEIS2

4212
CPCMR|HsT18361|MRG1
Meis homeobox 2
protein-coding
15q14
Ensembl:ENSG00000134138 MIM:601740 Vega:OTTHUMG00000129781 UniprotKB:O14770
NG_029108.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.337e-1 (AD)  8.966e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs837136chr15:36920696 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP3K50.829
CADM10.819
WFS10.804
SLITRK20.787
FAM118B0.774
SLC1A40.767
ABHD17C0.765
HERPUD20.762
KREMEN10.749
FAM210B0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.531
OR4F29-0.466
CETP-0.334
OR6C74-0.319
GZMK-0.318
GADL1-0.315
FMO1-0.295
IFNG-0.29
C2orf83-0.289
FCRL1-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MEIS2 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of MEIS2 mRNA17034753
C0418194-oxoretinol4-oxoretinol results in increased expression of MEIS2 mRNA17034753
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MEIS2 mRNA21420995
D000393Air PollutantsAir Pollutants analog results in decreased expression of MEIS2 mRNA21757418
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MEIS2 gene28843141
D000452AldrinAldrin results in increased expression of MEIS2 mRNA18579281
C103303alitretinoinalitretinoin results in increased expression of MEIS2 mRNA17034753
D006710HomocysteineHomocysteine results in decreased expression of MEIS2 mRNA17326132
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MEIS2 mRNA24449571
C004984apocarotenalapocarotenal results in increased expression of MEIS2 mRNA17034753
D001151ArsenicMEIS2 mRNA results in increased susceptibility to Arsenic17976673
D001152ArsenicalsArsenicals results in increased methylation of MEIS2 promoter26039340
C015001arsenitearsenite results in increased methylation of MEIS2 promoter23974009
D001280AtrazineAtrazine results in decreased expression of MEIS2 mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of MEIS2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MEIS2 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MEIS2 mRNA21715664|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MEIS2 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MEIS2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MEIS2 mRNA"19150397|2038263
D019207beta Carotenebeta Carotene results in increased expression of MEIS2 mRNA17034753
D004958EstradiolEstradiol affects the expression of MEIS2 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of MEIS2 mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of MEIS2 mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of MEIS2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of MEIS2 mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MEIS2 mRNA18668222
D019327Copper SulfateCopper Sulfate results in decreased expression of MEIS2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of MEIS2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MEIS2 mRNA20106945
D002945CisplatinCisplatin results in decreased expression of MEIS2 mRNA19561079
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MEIS2 mRNA"22485181
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MEIS2 mRNA22079256
D000431EthanolEthanol results in decreased expression of MEIS2 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MEIS2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MEIS2 mRNA17557909
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MEIS2 mRNA28329830
D017313FenretinideFenretinide results in increased expression of MEIS2 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of MEIS2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of MEIS2 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of MEIS2 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MEIS2 mRNA25307878
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of MEIS2 mRNA]26733615
C410337K 7174K 7174 results in decreased expression of MEIS2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of MEIS2 mRNA28988120
C467567lenalidomidelenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]25043012
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MEIS2 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MEIS2 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MEIS2 mRNA29191790
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MEIS2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MEIS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MEIS2 mRNA"25554681
D009532NickelNickel results in decreased expression of MEIS2 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of MEIS2 mRNA22714537
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of MEIS2 gene28843141
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of MEIS2 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of MEIS2 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of MEIS2 mRNA]26733615
D010634PhenobarbitalPhenobarbital affects the expression of MEIS2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MEIS2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MEIS2 mRNA19710929
D010894PiroxicamPiroxicam results in decreased expression of MEIS2 mRNA21858171
C467566pomalidomidepomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]25043012
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MEIS2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MEIS2 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of MEIS2 mRNA19690047
C043680ptaquilosideptaquiloside results in decreased expression of MEIS2 mRNA23274088
D011794QuercetinQuercetin results in decreased expression of MEIS2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MEIS2 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of MEIS2 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in decreased expression of MEIS2 mRNA23274088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEIS2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEIS2 mRNA24058054|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of MEIS2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MEIS2 mRNA19465110|2188995
D013792ThalidomideThalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]25043012
C009495titanium dioxidetitanium dioxide results in increased expression of MEIS2 mRNA23557971
D014212TretinoinTretinoin results in increased expression of MEIS2 mRNA16107473
D014212TretinoinTretinoin results in increased expression of MEIS2 protein16107473
D014212TretinoinTretinoin results in increased expression of MEIS2 mRNA17034753|2193413
D014212TretinoinTretinoin results in increased expression of MEIS2 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MEIS2 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MEIS2 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of MEIS2 mRNA28973697
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of MEIS2 mRNA28666766
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEIS2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MEIS2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MEIS2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MEIS2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of MEIS2 mRNA26682919
D014801Vitamin AVitamin A results in increased expression of MEIS2 mRNA17034753
D014801Vitamin A[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA16397886
D014801Vitamin ARARG gene mutant form inhibits the reaction [[RARA gene mutant form co-treated with Vitamin A] results in increased expression of MEIS2 mRNA]16397886

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10764806  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10764806  
GO:0003677DNA binding-IDA26550823  
GO:0003700DNA-binding transcription factor activity-NAS10764806  
GO:0003712transcription coregulator activity-ISS-  
GO:0003714transcription corepressor activity-TAS10764806  
GO:0005515protein binding-IPI22458338  25416956  
GO:0008134transcription factor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS10764806  
GO:0001654eye development-IEA-  
GO:0006366transcription by RNA polymerase II-TAS10764806  
GO:0008542visual learning-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0031016pancreas development-IEA-  
GO:0045638negative regulation of myeloid cell differentiation-ISS-  
GO:0045931positive regulation of mitotic cell cycle-IDA26512644  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10764806  
GO:0070848response to growth factor-IEA-  
GO:0110024positive regulation of cardiac muscle myoblast proliferation-IDA26512644  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal