Gene: MSRA

4482
PMSR
methionine sulfoxide reductase A
protein-coding
8p23.1
Ensembl:ENSG00000175806 MIM:601250 Vega:OTTHUMG00000090517 UniprotKB:Q9UJ68
NC_000008.11
PubMed|SNP Mapped
3   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.701e-1 (AD)  4.390e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4509385chr8:10322686 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs10089263chr8:10318996 (GRCh38.p7)A>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs7844115chr8:10206985 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15678504chr8:10262159MSRAGene body3.094e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LYRM40.904
MCTS10.9
SPINT20.899
HPRT10.897
NLRP10.893
NME10.893
EID20.892
YWHAH0.887
NDUFAB10.887
GGCT0.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.543
OR4F29-0.504
REST-0.477
ASB4-0.462
PARD3B-0.447
MBNL3-0.427
CDC14A-0.424
LATS2-0.423
RAI14-0.422
HEY2-0.415

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB044471,4-DithiothreitolSmall Molecule3483-12-3ExperimentalTarget
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MSRA mRNA"19114083
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in decreased expression of MSRA mRNA25781201
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MSRA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MSRA mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MSRA mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MSRA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MSRA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MSRA mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MSRA mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of MSRA protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MSRA mRNA16483693
D001149ArsenatesArsenates results in decreased expression of MSRA mRNA19895865
D001151ArsenicArsenic affects the methylation of MSRA gene25304211
D001280AtrazineAtrazine results in increased expression of MSRA mRNA22378314
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MSRA mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSRA mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSRA mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSRA mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MSRA mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of MSRA mRNA25181051
D020122tert-ButylhydroperoxideMSRA protein results in decreased susceptibility to tert-Butylhydroperoxide15914630
C018475butyraldehydebutyraldehyde results in decreased expression of MSRA mRNA26079696
C584509C646 compoundC646 compound results in increased expression of MSRA mRNA26191083
C034939cadmium sulfidecadmium sulfide results in increased expression of MSRA mRNA27866839
D002220CarbamazepineCarbamazepine affects the expression of MSRA mRNA25979313
D002244Carbon[Nickel co-treated with Carbon] results in increased expression of MSRA protein25979628
C026690cerous chloridecerous chloride results in decreased expression of MSRA mRNA28954213
C016300chloramine-TMSRA protein results in decreased susceptibility to chloramine-T19085252
C016300chloramine-TS-methylcysteine promotes the reaction [MSRA protein results in decreased susceptibility to chloramine-T]19085252
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MSRA mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of MSRA mRNA19549813
C014347decitabinedecitabine affects the expression of MSRA mRNA23300844
D002945CisplatinCisplatin affects the expression of MSRA mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MSRA mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MSRA mRNA27392435|2759478
D002945CisplatinCisplatin results in decreased expression of MSRA mRNA22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MSRA mRNA18164116
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased activity of MSRA protein23022493
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MSRA mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSRA mRNA17942748
D005839GentamicinsGentamicins results in decreased expression of MSRA mRNA22061828
D005839GentamicinsGentamicins results in decreased expression of MSRA protein21081137|2206182
D007052IbuprofenIbuprofen results in increased expression of MSRA mRNA28201806
C082770IMM 125IMM 125 results in decreased expression of MSRA protein21081137
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MSRA mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MSRA mRNA27392435
C410337K 7174K 7174 results in decreased expression of MSRA mRNA24086573
D008715MethionineMSRA protein results in increased chemical synthesis of Methionine19085252
C013111methionine sulfoxideMSRA protein results in increased reduction of methionine sulfoxide19085252
C523799MRK 003MRK 003 results in decreased expression of MSRA mRNA21169257
D009151Mustard GasMustard Gas results in decreased expression of MSRA mRNA25102026
D009532Nickel[Nickel co-treated with Carbon] results in increased expression of MSRA protein25979628
D009532NickelNickel results in decreased expression of MSRA protein25979628
D009534NiclosamideNiclosamide results in increased expression of MSRA mRNA26452273
C025589ochratoxin Aochratoxin A affects the expression of MSRA mRNA17483316
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MSRA mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MSRA mRNA22230185
D010100OxygenOxygen results in increased expression of MSRA mRNA22230185
D010100OxygenOxygen deficiency results in increased expression of MSRA mRNA22230185
D010100OxygenOxygen deficiency results in increased expression of MSRA mRNA22230185
D010269ParaquatMSRA protein results in decreased susceptibility to Paraquat11867705
D011374ProgesteroneProgesterone results in decreased expression of MSRA mRNA23018184
C005556propionaldehydepropionaldehyde results in decreased expression of MSRA mRNA26079696
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of MSRA mRNA29085557
C059514resveratrolNiacinamide inhibits the reaction [resveratrol results in increased expression of MSRA protein]23022493
C059514resveratrolresveratrol results in increased expression of MSRA protein23022493
C059514resveratrolSIRT1 protein affects the reaction [resveratrol results in increased expression of MSRA protein]23022493
D012834SilverSilver results in decreased expression of MSRA mRNA27131904
C008425S-methylcysteineS-methylcysteine promotes the reaction [MSRA protein results in decreased susceptibility to chloramine-T]19085252
C017947sodium arsenitesodium arsenite results in increased expression of MSRA mRNA28229933
C016104sodium bichromatesodium bichromate results in decreased expression of MSRA mRNA17685462
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSRA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSRA mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSRA mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MSRA mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of MSRA mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MSRA mRNA25729387
D014635Valproic AcidValproic Acid results in decreased expression of MSRA mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MSRA gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of MSRA mRNA26682919
D009536NiacinamideNiacinamide inhibits the reaction [resveratrol results in increased expression of MSRA protein]23022493
D014810Vitamin EVitamin E results in increased expression of MSRA mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008113peptide-methionine (S)-S-oxide reductase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-TAS10452521  
GO:0006555methionine metabolic process-TAS10452521  
GO:0006979response to oxidative stress-TAS10452521  
GO:0030091protein repair-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0015629actin cytoskeleton-IDA-  
GO:0016020membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5676934Protein repairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet