Gene info: ID 4628

Gene: MYH10

GENE ID: 4628

Synonyms: NMMHC-IIB|NMMHCB

Description: myosin heavy chain 10

Gene type: protein-coding

Location: 17p13.1

dbXrefs: Ensembl:ENSG00000133026 MIM:160776 Vega:OTTHUMG00000108195 UniprotKB:P35580

RefSeq: NG_042305.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.957e-1 (AD) 2.794e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7208821	chr17:8573425 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16595056	chr17:8380530	MYH10	Gene body	7.210e-4	Alcohol use disorders	26763658
cg09975715	chr17:8379050	MYH10		1.400e-13	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MADD	0.978
KALRN	0.978
TLN2	0.976
PI4KA	0.976
BTRC	0.976
DOCK3	0.975
KCNMA1	0.973
LMTK2	0.971
INPP4A	0.971
RBFOX2	0.971

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.542
YES1	-0.519
MYL3	-0.516
RAI14	-0.511
RAB13	-0.508
WWTR1	-0.504
REST	-0.503
OR4F5	-0.502
TFPI2	-0.499
SNHG18	-0.496

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MYH10 mRNA"	23196670
D000082	Acetaminophen	Acetaminophen affects the expression of MYH10 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of MYH10 mRNA	17942131
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of MYH10 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MYH10 mRNA	23630614
D006710	Homocysteine	Homocysteine results in decreased expression of MYH10 mRNA	17326132
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MYH10 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of MYH10 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of MYH10 gene	25304211
D001151	Arsenic	MYH10 mRNA results in increased susceptibility to Arsenic	17976673
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of MYH10 mRNA	26238599
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MYH10 mRNA	20458559
D001280	Atrazine	Atrazine results in decreased expression of MYH10 mRNA	22378314
C547126	AZM551248	AZM551248 results in increased expression of MYH10 mRNA	22323515
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MYH10 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MYH10 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MYH10 mRNA	17942131
D004958	Estradiol	Estradiol affects the expression of MYH10 mRNA	22574217
D004958	Estradiol	Estradiol affects the localization of and results in increased expression of and results in increased phosphorylation of and affects the activity of MYH10 protein	16901965
D004958	Estradiol	Estradiol inhibits the reaction [MYH10 protein binds to MYH10 protein]	16901965
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of MYH10 protein]	16901965
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MYH10 protein]	16901965
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYH10 protein]	16901965
C044887	beta-methylcholine	beta-methylcholine affects the expression of MYH10 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of MYH10 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of MYH10 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of MYH10 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of MYH10 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MYH10 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of MYH10 mRNA	17942131
C013418	bromfenacoum	bromfenacoum results in increased expression of MYH10 protein	28903499
D002104	Cadmium	Cadmium results in decreased expression of MYH10 mRNA	23369406
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MYH10 mRNA	17484886
C100187	chloropicrin	chloropicrin results in increased expression of MYH10 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MYH10 gene	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MYH10 mRNA	19320972
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MYH10 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MYH10 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of MYH10 mRNA	26577399
D003520	Cyclophosphamide	MYH10 protein affects the susceptibility to Cyclophosphamide	16217747
D016572	Cyclosporine	Cyclosporine results in decreased expression of MYH10 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of MYH10 mRNA	17942131\|1977048
D000069439	Dasatinib	Dasatinib results in increased expression of MYH10 mRNA	20579391
D013759	Dronabinol	Dronabinol results in increased expression of MYH10 mRNA	16597638
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MYH10 mRNA]	27941970
D003976	Diazinon	Diazinon results in increased methylation of MYH10 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MYH10 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MYH10 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of MYH10 mRNA	19561079\|2739243
C000944	dicrotophos	dicrotophos results in increased expression of MYH10 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of MYH10 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of MYH10 mRNA	21852083
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of MYH10 mRNA]	21852083
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MYH10 mRNA	18164116
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [MYH10 protein binds to MYH10 protein]	16901965
D004317	Doxorubicin	Doxorubicin affects the expression of MYH10 protein	29385562
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MYH10 protein	23301498
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MYH10 mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of MYH10 mRNA	17557909
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MYH10 gene	20938992
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of MYH10 protein]	16901965
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of MYH10 protein]	16901965
C039281	furan	furan results in decreased methylation of MYH10 gene	27387713
C039281	furan	furan results in increased expression of MYH10 mRNA	25539665\|2738771
D019833	Genistein	ESR1 promotes the reaction [Genistein results in increased expression of MYH10 protein]	20884965
D019833	Genistein	Genistein results in increased expression of MYH10 protein	20884965
C492448	ICG 001	ICG 001 results in increased expression of MYH10 mRNA	26191083
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of MYH10 mRNA	21396975
C051890	irinotecan	irinotecan analog results in decreased expression of MYH10 mRNA	18927307
D007657	Ketone Bodies	Ketone Bodies results in increased expression of MYH10 mRNA	16807920
C045463	leflunomide	leflunomide results in decreased expression of MYH10 mRNA	24136188
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MYH10 gene	20938992
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of MYH10 protein	26558463
C070571	ML 7	ML 7 affects the localization of MYH10 protein	12729566
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MYH10 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MYH10 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of MYH10 mRNA	24768652\|2558310
C029938	nickel sulfate	nickel sulfate results in decreased expression of MYH10 mRNA	16780908
D009543	Nifedipine	Nifedipine results in decreased expression of MYH10 protein	20530298
D009543	Nifedipine	Nifedipine results in decreased expression of MYH10 protein	20530298
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MYH10 mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MYH10 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of MYH10 mRNA	25729387
D010126	Ozone	Ozone results in decreased expression of MYH10 mRNA	17095637
D000073878	Palm Oil	Palm Oil results in increased expression of MYH10 mRNA	18042831
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of MYH10 protein	26178269
D010578	Petroleum	Petroleum affects the expression of MYH10 mRNA	25208076
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MYH10 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of MYH10 mRNA	17950772
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MYH10 mRNA]	17950772
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MYH10 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of MYH10 mRNA	22079256
D011374	Progesterone	Progesterone results in decreased expression of MYH10 mRNA	21795739
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MYH10 mRNA	24780913
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of MYH10 mRNA	7671567\|8918620
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside affects the expression of MYH10 protein	8918620
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of MYH10 protein	7671567
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of MYH10 mRNA]	21852083
D019821	Simvastatin	Simvastatin results in decreased expression of MYH10 protein	16005304
C009277	sodium arsenate	sodium arsenate results in increased expression of MYH10 mRNA	21795629
D053260	Soot	Soot results in decreased expression of MYH10 mRNA	26551751
C025462	sulindac sulfide	sulindac sulfide results in increased expression of MYH10 mRNA	12734198
C061133	tamibarotene	tamibarotene results in decreased expression of MYH10 mRNA	16224062
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MYH10 protein]	16901965
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MYH10 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MYH10 mRNA	25270620
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MYH10 mRNA	22298810
D019284	Thapsigargin	Thapsigargin results in decreased expression of MYH10 mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in increased expression of MYH10 mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MYH10 mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MYH10 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of MYH10 mRNA	25729387
C057693	troglitazone	troglitazone results in decreased expression of MYH10 mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in decreased expression of MYH10 mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of MYH10 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MYH10 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of MYH10 mRNA	17292431\|1796380
C111237	vorinostat	vorinostat results in decreased expression of MYH10 mRNA	27188386
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of MYH10 mRNA"	25208076
D015032	Zinc	Zinc results in decreased expression of MYH10 mRNA	20932299

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000146	microfilament motor activity	-	IDA	15845534
GO:0003777	microtubule motor activity	-	IEA	-
GO:0003779	actin binding	-	NAS	7782316
GO:0005515	protein binding	-	IPI	7542763 14743216 17353931 20603131
GO:0005516	calmodulin binding	-	IEA	-
GO:0005524	ATP binding	-	IDA	15845534
GO:0005524	ATP binding	-	NAS	7782316
GO:0008017	microtubule binding	-	IEA	-
GO:0016887	ATPase activity	-	IMP	24072716
GO:0030898	actin-dependent ATPase activity	-	IDA	15845534
GO:0030898	actin-dependent ATPase activity	contributes_to	IMP	24072716
GO:0035613	RNA stem-loop binding	-	IDA	20603131
GO:0043531	ADP binding	-	IDA	15845534
GO:0048027	mRNA 5'-UTR binding	-	IDA	20603131
GO:0051015	actin filament binding	-	IDA	15845534
GO:0051015	actin filament binding	contributes_to	IMP	24072716

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000281	mitotic cytokinesis	-	IDA	15774463
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001764	neuron migration	-	IEA	-
GO:0001778	plasma membrane repair	-	IEA	-
GO:0003279	cardiac septum development	-	IEA	-
GO:0006887	exocytosis	-	IEA	-
GO:0006930	substrate-dependent cell migration, cell extension	-	IEA	-
GO:0007018	microtubule-based movement	-	IEA	-
GO:0007097	nuclear migration	-	IEA	-
GO:0007155	cell adhesion	-	IEA	-
GO:0007411	axon guidance	-	IEA	-
GO:0007512	adult heart development	-	IEA	-
GO:0008283	cell proliferation	-	IEA	-
GO:0008360	regulation of cell shape	-	IEA	-
GO:0021592	fourth ventricle development	-	IEA	-
GO:0021670	lateral ventricle development	-	IEA	-
GO:0021678	third ventricle development	-	IEA	-
GO:0021680	cerebellar Purkinje cell layer development	-	IEA	-
GO:0030048	actin filament-based movement	-	IDA	15845534
GO:0031032	actomyosin structure organization	-	IMP	24072716
GO:0035904	aorta development	-	IEA	-
GO:0050714	positive regulation of protein secretion	-	IMP	20603131
GO:0050885	neuromuscular process controlling balance	-	IEA	-
GO:0055003	cardiac myofibril assembly	-	IEA	-
GO:0055015	ventricular cardiac muscle cell development	-	IEA	-
GO:0060041	retina development in camera-type eye	-	IEA	-
GO:0060976	coronary vasculature development	-	IEA	-
GO:0098885	modification of postsynaptic actin cytoskeleton	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001725	stress fiber	-	IDA	7699007 15774463
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IDA	7699007
GO:0005819	spindle	-	IEA	-
GO:0005829	cytosol	-	IMP	20603131
GO:0005829	cytosol	-	TAS	-
GO:0005844	polysome	-	IMP	20603131
GO:0005903	brush border	-	IEA	-
GO:0005938	cell cortex	-	IDA	7699007
GO:0016459	myosin complex	-	NAS	7499478
GO:0016460	myosin II complex	-	IDA	24072716
GO:0030027	lamellipodium	-	IEA	-
GO:0030426	growth cone	-	IEA	-
GO:0030496	midbody	-	IDA	11029059
GO:0031594	neuromuscular junction	-	IEA	-
GO:0032154	cleavage furrow	-	IDA	7699007 11029059
GO:0042641	actomyosin	-	IDA	24072716
GO:0043025	neuronal cell body	-	IEA	-
GO:0043197	dendritic spine	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0097513	myosin II filament	-	IDA	24072716

KEGG ID	KEGG Term
hsa04530	Tight junction
hsa04810	Regulation of actin cytoskeleton
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-194315	Signaling by Rho GTPases	IEA
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	IEA
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-3928663	EPHA-mediated growth cone collapse	IEA
R-HSA-400685	Sema4D in semaphorin signaling	IEA
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-5625740	RHO GTPases activate PKNs	IEA
R-HSA-5625900	RHO GTPases activate CIT	IEA
R-HSA-5627117	RHO GTPases Activate ROCKs	IEA
R-HSA-5627123	RHO GTPases activate PAKs	IEA
R-HSA-5627123	RHO GTPases activate PAKs	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal