Gene: MYO9B

4650
CELIAC4|MYR5
myosin IXB
protein-coding
19p13.11
Ensembl:ENSG00000099331 MIM:602129 Vega:OTTHUMG00000182707 UniprotKB:Q13459
NG_013068.1
SNP Mapped
1   ANCO-SNPs
AD
0   
4.845e-1 (AD)  2.187e-1 (ND)   (Frontal_Cortex)
3.852e-1 (AD)  6.420e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11667918chr19:17121689 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NADSYN10.89
ARHGEF10.887
DNM20.882
TTC7A0.86
CDK5RAP20.833
SLC12A90.828
DNHD10.826
CLASRP0.821
ANKRD13A0.819
UNC5B0.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.456
OR4F29-0.454
CRH-0.256
CALB2-0.239
NPBWR1-0.226
HES5-0.226
VIP-0.225
PTGFR-0.221
PKP2-0.211
NDNF-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MYO9B mRNA"27291303
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MYO9B mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MYO9B mRNA16788091
D000082AcetaminophenAcetaminophen results in increased expression of MYO9B mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MYO9B mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of MYO9B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MYO9B mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYO9B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MYO9B mRNA24449571
D001151ArsenicArsenic affects the methylation of MYO9B gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of MYO9B protein15894607
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of MYO9B protein15894607
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MYO9B promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYO9B mRNA21715664|2222880
C044887beta-methylcholinebeta-methylcholine affects the expression of MYO9B mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MYO9B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MYO9B gene28505145
C032036bromobenzenebromobenzene results in decreased expression of MYO9B mRNA15056800
D016572CyclosporineCyclosporine results in increased expression of MYO9B mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MYO9B mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MYO9B mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of MYO9B mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of MYO9B mRNA22609946
C056516exemestaneexemestane results in increased expression of MYO9B mRNA17254854
C069837fullerene C60fullerene C60 results in increased expression of MYO9B mRNA19167457
D005839GentamicinsGentamicins results in increased expression of MYO9B mRNA22061828
C010974glyphosateglyphosate affects the expression of MYO9B mRNA26302742
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of MYO9B mRNA19376150
D007052IbuprofenIbuprofen results in increased expression of MYO9B mRNA28201806
C492448ICG 001ICG 001 affects the expression of MYO9B mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYO9B mRNA25613284
C518329isopropyl-9H-thioxanthen-9-oneisopropyl-9H-thioxanthen-9-one results in increased expression of MYO9B mRNA20558275
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MYO9B mRNA28001369
C028007nickel monoxidenickel monoxide results in increased expression of MYO9B mRNA19167457
D005996NitroglycerinNitroglycerin results in decreased expression of MYO9B mRNA12102619
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of MYO9B mRNA23948077
C009277sodium arsenatesodium arsenate results in decreased expression of MYO9B mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYO9B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MYO9B promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MYO9B mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYO9B mRNA25613284
D014112ToxapheneToxaphene results in increased expression of MYO9B mRNA21220043
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of MYO9B protein15894607
D014635Valproic AcidValproic Acid results in decreased expression of MYO9B mRNA23527032
D014635Valproic AcidValproic Acid results in increased methylation of MYO9B gene29154799
D014635Valproic AcidValproic Acid affects the expression of MYO9B mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000146microfilament motor activity-IDA9490638  11901422  16616011  
GO:0003777microtubule motor activity-IEA-  
GO:0003779actin binding-IDA9490638  16338935  16616011  
GO:0005096GTPase activator activity-IDA9490638  15644318  26529257  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI15644318  16417406  
GO:0005516calmodulin binding-IDA9490638  16338935  
GO:0005524ATP binding-IDA16338935  
GO:0008017microtubule binding-IEA-  
GO:0016887ATPase activity-IDA16338935  
GO:0017048Rho GTPase binding-IPI26529257  
GO:0042803protein homodimerization activityNOTIDA11901422  
GO:0043531ADP binding-IDA16338935  
GO:0046872metal ion binding-IEA-  
GO:0048495Roundabout binding-IPI26529257  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IEA-  
GO:0007266Rho protein signal transduction-IC9490638  
GO:0030048actin filament-based movement-IDA9490638  
GO:0030048actin filament-based movement-TAS8907710  
GO:0032011ARF protein signal transductionNOTIDA15644318  
GO:0035023regulation of Rho protein signal transduction-IMP26529257  
GO:0035385Roundabout signaling pathway-IDA26529257  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA8907710  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005884actin filament-IDA8907710  16338935  16616011  
GO:0005938cell cortex-IDA8907710  
GO:0015629actin cytoskeleton-TAS8907710  
GO:0016020membrane-HDA19946888  
GO:0016459myosin complex-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA8907710  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8985586SLIT2:ROBO1 increases RHOA activityTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal