Gene: NAP1L4

4676
NAP1L4b|NAP2|NAP2L|hNAP2
nucleosome assembly protein 1 like 4
protein-coding
11p15.4
Ensembl:ENSG00000205531 MIM:601651 Vega:OTTHUMG00000011009 UniprotKB:Q99733
NC_000011.10
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.554e-1 (AD)  1.275e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4758621chr11:2988410 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs3814964chr11:2978277 (GRCh38.p7)G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ECHS10.934
PEBP10.934
YWHAE0.93
GNPTG0.925
LDHB0.92
OAZ20.917
RAB11B0.914
PARK70.914
CBX10.912
COPS60.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.88
OR4F5-0.88
KRT73-0.307
FER1L6-0.295
C2orf83-0.293
GADL1-0.29
DPPA4-0.288
FCER2-0.283
GSDMA-0.282
SULT1E1-0.277

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NAP1L4 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NAP1L4 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of NAP1L4 mRNA17562736
D001151ArsenicArsenic affects the methylation of NAP1L4 gene25304211
D001280AtrazineAtrazine results in increased expression of NAP1L4 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of NAP1L4 mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NAP1L4 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of NAP1L4 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NAP1L4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NAP1L4 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of NAP1L4 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of NAP1L4 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NAP1L4 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NAP1L4 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of NAP1L4 mRNA25979313
D003375CoumestrolCoumestrol results in increased expression of NAP1L4 mRNA19167446
C030973cupric oxidecupric oxide results in increased phosphorylation of NAP1L4 protein25470785
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NAP1L4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NAP1L4 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NAP1L4 mRNA17361019
D002945CisplatinCisplatin results in increased expression of NAP1L4 mRNA27392435
D004147DioxinsDioxins affects the expression of NAP1L4 mRNA20463971
D004317DoxorubicinDoxorubicin affects the expression of NAP1L4 protein29385562
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NAP1L4 mRNA17942748
D005485FlutamideFlutamide results in increased expression of NAP1L4 mRNA24136188
D019833GenisteinGenistein results in decreased expression of NAP1L4 mRNA16705744
D005839GentamicinsGentamicins results in increased expression of NAP1L4 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NAP1L4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NAP1L4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NAP1L4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NAP1L4 mRNA28628672
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of NAP1L4 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NAP1L4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NAP1L4 protein26558463
D009151Mustard GasMustard Gas results in increased phosphorylation of NAP1L4 protein19845377
C025256nonylphenolnonylphenol results in decreased expression of NAP1L4 mRNA22982499
D010126OzoneOzone results in increased expression of NAP1L4 mRNA12763052
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NAP1L4 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of NAP1L4 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAP1L4 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAP1L4 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NAP1L4 mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of NAP1L4 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI22190034  
GO:0031491nucleosome binding-IDA9325046  
GO:0051082unfolded protein binding-TAS9325046  
GO ID GO Term Qualifier Evidence PubMed
GO:0006334nucleosome assembly-IDA9325046  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9325046  
GO:0005737cytoplasm-IDA9325046  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res