Gene: NELL1

4745
IDH3GL|NRP1
neural EGFL like 1
protein-coding
11p15.1
Ensembl:ENSG00000165973 MIM:602319 Vega:OTTHUMG00000166042 UniprotKB:Q92832
NG_047064.1
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.779e-2 (AD)  9.135e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1400369chr11:20994749 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10500885chr11:20993514 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11825833chr11:20831700 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1554368chr11:20754212 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs1996623chr11:20737870 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPN30.952
ATP8A20.947
HECW10.946
OSBPL100.945
OPCML0.944
PTPRT0.943
ZNF385B0.941
FAM102B0.94
AMPH0.94
DCLK10.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST14-0.606
REST-0.603
HEY2-0.6
STON2-0.597
YES1-0.597
RAB13-0.592
RNF135-0.588
SYDE1-0.577
COPZ2-0.57
HVCN1-0.563

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NELL1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NELL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NELL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NELL1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NELL1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NELL1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NELL1 mRNA24449571
C015001arsenitearsenite results in increased methylation of NELL1 promoter23974009
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA]15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of NELL1 gene25435355
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NELL1 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of NELL1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of NELL1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NELL1 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of NELL1 gene28505145
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of NELL1 mRNA18636392
D003300CopperCopper results in decreased expression of NELL1 mRNA18522721
D019327Copper SulfateCopper Sulfate results in decreased expression of NELL1 mRNA19549813
C014347decitabinedecitabine affects the methylation of NELL1 promoter17452981
C014347decitabine[decitabine affects the methylation of NELL1 promoter] which affects the expression of NELL1 mRNA17452981|1745298
D019422Dietary SucroseDietary Sucrose results in increased expression of NELL1 mRNA26033743
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of NELL1 mRNA"19480007
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NELL1 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NELL1 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NELL1 mRNA17351261|2686566
D005419FlavonoidsFlavonoids results in increased expression of NELL1 mRNA18035473
D004397FonofosFonofos results in increased methylation of NELL1 promoter22847954
D019833GenisteinGenistein results in decreased expression of NELL1 mRNA26865667
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of NELL1 mRNA19376150
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA15477007
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NELL1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NELL1 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NELL1 mRNA26924002
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of NELL1 mRNA18636392
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NELL1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of NELL1 mRNA26272509
D010278ParathionParathion results in increased methylation of NELL1 promoter22847954
C024273profenofosprofenofos results in decreased expression of NELL1 mRNA17569032
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA]15477007
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NELL1 mRNA22431001
C017947sodium arsenitesodium arsenite affects the methylation of NELL1 gene28589171
C012568terbufosterbufos results in increased methylation of NELL1 promoter22847954
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA15477007
D014212TretinoinTretinoin results in decreased expression of NELL1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of NELL1 mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of NELL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NELL1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NELL1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of NELL1 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI21723284  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS8975702  
GO:0010468regulation of gene expression-IDA21723284  
GO:0030154cell differentiation-IEA-  
GO:0030501positive regulation of bone mineralization-IDA21723284  
GO:0033689negative regulation of osteoblast proliferation-IDA21723284  
GO:0045669positive regulation of osteoblast differentiation-IDA21723284  
GO:1903363negative regulation of cellular protein catabolic process-IDA21723284  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005635nuclear envelope-IDA21723284  
GO:0005737cytoplasm-IDA21723284  
GO:0048471perinuclear region of cytoplasm-IDA21723284  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20572039Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. (2010 Oct 1)Paun BCCancer