Gene: NRAP

4892
N-RAP
nebulin related anchoring protein
protein-coding
10q25.3
Ensembl:ENSG00000197893 MIM:602873 Vega:OTTHUMG00000019072 UniprotKB:Q86VF7
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.072e-1 (AD)  6.137e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3121491chr10:113662237 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMOD20.81
XIRP20.781
MB0.769
MYH70.764
TRIM630.747
TTN0.728
TNNC10.726
CKM0.719
MYL20.713
C10orf710.712

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG8-0.325
SAC3D1-0.314
ZNF575-0.307
BOLA1-0.305
FBXO15-0.303
ZNF835-0.3
HDDC3-0.291
DOHH-0.289
TMEM53-0.286
E2F1-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of NRAP mRNA"28940058
D000082AcetaminophenAcetaminophen affects the expression of NRAP mRNA25064622
D000638AmiodaroneAmiodarone affects the expression of NRAP mRNA25064622
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NRAP mRNA22316170
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NRAP mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NRAP mRNA22228805
D004958EstradiolEstradiol results in decreased expression of NRAP mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of NRAP mRNA25181051|2717856
D002746ChlorpromazineChlorpromazine affects the expression of NRAP mRNA25064622
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of NRAP mRNA]16940432
D019327Copper SulfateCopper Sulfate results in increased expression of NRAP mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of NRAP mRNA27523638
D003520CyclophosphamideCyclophosphamide results in increased expression of NRAP mRNA27281708
D016572CyclosporineCyclosporine affects the expression of NRAP mRNA25064622
D003630DaunorubicinDaunorubicin results in decreased expression of NRAP mRNA26537877|2894005
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NRAP mRNA24317228
D003907DexamethasoneDexamethasone results in increased expression of NRAP mRNA22733784
D004041Dietary FatsDietary Fats results in increased expression of NRAP mRNA18042831
D019422Dietary SucroseDietary Sucrose results in increased expression of NRAP mRNA26033743
D004317DoxorubicinDoxorubicin results in decreased expression of NRAP mRNA26537877|2894005
D004726EndosulfanEndosulfan results in decreased expression of NRAP mRNA26615145
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NRAP mRNA25064622
D004397FonofosFonofos results in increased methylation of NRAP promoter22847954
D006108GraphiteGraphite results in increased expression of NRAP mRNA27440207
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NRAP mRNA26011545
D008942MitoxantroneMitoxantrone results in decreased expression of NRAP mRNA26537877|2894005
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of NRAP mRNA22401849
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of NRAP mRNA]16940432
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NRAP mRNA27935865
D000073878Palm OilPalm Oil results in increased expression of NRAP mRNA18042831
D010269ParaquatParaquat affects the expression of NRAP mRNA25064622
D010278ParathionParathion results in increased methylation of NRAP promoter22847954
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NRAP mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of NRAP mRNA23557933
C017947sodium arsenitesodium arsenite affects the expression of NRAP mRNA22058191
D053260SootSoot results in increased expression of NRAP mRNA26551751
C012568terbufosterbufos results in increased methylation of NRAP promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NRAP mRNA21570461
D013752TetracyclineTetracycline affects the expression of NRAP mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of NRAP mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of NRAP mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NRAP mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of NRAP mRNA25064622

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-ISS-  
GO:0003779actin binding-NAS9339382  
GO:0005515protein binding-IPI15205937  
GO:0046872metal ion binding-IEA-  
GO:0051015actin filament binding-IBA21873635  
GO:0051371muscle alpha-actinin binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0048747muscle fiber development-IBA21873635  
GO:0071691cardiac muscle thin filament assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005916fascia adherens-ISS-  
GO:0005927muscle tendon junction-ISS-  
GO:0030018Z disc-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal