Gene: NTRK2

4915
EIEE58|GP145-TrkB|OBHD|TRKB|trk-B
neurotrophic receptor tyrosine kinase 2
protein-coding
9q21.33
Ensembl:ENSG00000148053 MIM:600456 Vega:OTTHUMG00000020120 UniprotKB:Q16620
NG_012201.2
PubMed|SNP Mapped
3   ANCO-SNPs
CD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.844e-1 (AD)  2.952e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4877900chr9:85017403 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7026417chr9:84974250 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10868236chr9:84893781 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A20.945
SPON10.936
GJA10.928
SLC1A30.922
ATP13A40.919
HEPACAM0.918
METTL7A0.913
GABRG10.912
SLC4A40.909
ACSBG10.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.473
OR4F29-0.433
CETP-0.346
KLK8-0.338
TDRD1-0.326
GADL1-0.326
L1TD1-0.313
FER1L6-0.312
C17orf112-0.304
SAMD3-0.303

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
ID Drug Name Action PubMed
C5822121NMPP1 compound1NMPP1 compound results in decreased activity of NTRK2 protein mutant form27417517
C5822121NMPP1 compoundNTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of CCK mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of CORT mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of DLG4 mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of GABRA5 mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of GAD1 mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of NPY mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of SST mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GABRB3 mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GRIA1 mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GRIN2A mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of GRIN2B mRNA27417517
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of NTRK2 mRNA27417517|2741751
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in increased expression of NTRK2 mRNA alternative form27417517|2741751
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of NTRK2 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NTRK2 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA"27188386
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of NTRK2 protein"21608528
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA"27188386
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA25607892
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]28499986
D020106AcrylamideAcrylamide results in decreased expression of NTRK2 mRNA28959563
D020106AcrylamideAcrylamide results in increased expression of NTRK2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NTRK2 gene27153756
D000452Aldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NTRK2 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of NTRK2 mRNA18681898
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA25607892
D001151ArsenicArsenic results in decreased phosphorylation of NTRK2 protein28903487
D001151ArsenicBDNF protein inhibits the reaction [Arsenic results in decreased phosphorylation of NTRK2 protein]28903487
D001151ArsenicNOG protein inhibits the reaction [Arsenic results in decreased phosphorylation of NTRK2 protein]28903487
C006632arsenic trioxidearsenic trioxide results in decreased expression of NTRK2 mRNA26705709
C006632arsenic trioxidearsenic trioxide results in decreased expression of NTRK2 protein16711005
C006632arsenic trioxidearsenic trioxide results in increased expression of NTRK2 protein16569477
C006632arsenic trioxidearsenic trioxide results in increased sumoylation of NTRK2 protein28318385
C006632arsenic trioxidearsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein]26114099
D001205Ascorbic AcidAscorbic Acid results in increased expression of NTRK2 mRNA15305145
D001280AtrazineAtrazine results in decreased expression of NTRK2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of NTRK2 mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of NTRK2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NTRK2 mRNA21569818|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NTRK2 mRNA22228805
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of NTRK2 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of NTRK2 mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of NTRK2 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of NTRK2 mRNA26869994
C006780bisphenol Abisphenol A affects the expression of NTRK2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK2 mRNA25607892
C006780bisphenol Abisphenol A results in increased expression of NTRK2 mRNA12075121
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA28628672
D002047BuprenorphineBuprenorphine results in decreased phosphorylation of NTRK2 protein24321744
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NTRK2 mRNA15336504
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK2 mRNA25607892
C018475butyraldehydebutyraldehyde results in increased expression of NTRK2 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
D020111Chlorodiphenyl (54% Chlorine)[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
D020111Chlorodiphenyl (54% Chlorine)[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form24394491
D020111Chlorodiphenyl (54% Chlorine)[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]24394491
D020111Chlorodiphenyl (54% Chlorine)[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NTRK2 mRNA18502319
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NTRK2 mRNA20938992
D015283CitalopramCitalopram results in increased phosphorylation of and results in increased activity of NTRK2 protein21666748
D002997ClomipramineClomipramine results in increased phosphorylation of NTRK2 protein22396798
D003042CocaineCocaine results in decreased expression of NTRK2 mRNA15009677|1671032
D003042CocaineCocaine affects the reaction [NTRK2 protein affects the expression of KCNA2 mRNA]20947769
D003042CocaineCocaine affects the reaction [NTRK2 protein affects the expression of KCNB1 mRNA]20947769
D003042CocaineCocaine affects the reaction [NTRK2 protein affects the expression of KCND1 mRNA]20947769
D003042CocaineCocaine affects the reaction [NTRK2 protein affects the expression of KCNJ4 mRNA]20947769
D003042CocaineCocaine affects the reaction [NTRK2 protein affects the expression of KCNJ8 mRNA]20947769
D003042CocaineCocaine results in decreased phosphorylation of NTRK2 protein24358339
D003042CocaineNTRK2 protein affects the reaction [Cocaine affects the expression of FOS protein]20947769
D003042CocaineCocaine affects the expression of NTRK2 mRNA12358776|2018794
D003042CocaineCocaine affects the expression of NTRK2 protein12358776
D003042CocaineCocaine results in decreased expression of NTRK2 mRNA16423334
D003042CocaineCocaine results in increased expression of NTRK2 protein20947769
D003300CopperCopper deficiency results in increased expression of NTRK2 mRNA26033743
C551994crizotinibcrizotinib results in decreased activity of NTRK2 protein21812414
D003471CuprizoneCuprizone results in increased expression of NTRK2 mRNA26577399|2752363
D003520CyclophosphamideCyclophosphamide results in increased phosphorylation of and results in increased expression of NTRK2 protein12412144
D016572CyclosporineCyclosporine results in increased methylation of NTRK2 promoter27989131
C017160cypermethrincypermethrin results in decreased expression of NTRK2 mRNA22528246
C093628cyproconazolecyproconazole results in increased expression of NTRK2 mRNA22045034
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form"18606552
D003634DDT[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
C014347decitabinedecitabine results in increased expression of NTRK2 mRNA19151715
D013759DronabinolDronabinol results in increased expression of NTRK2 mRNA15454482|1816398
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of NTRK2 mRNA29111458
D003976DiazinonDiazinon affects the expression of NTRK2 mRNA18502319|1913087
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
D003632Dichlorodiphenyldichloroethane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
D003633Dichlorodiphenyl Dichloroethylene[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
D004026Dieldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
D004026DieldrinDieldrin affects the expression of NTRK2 mRNA19130878
D004041Dietary FatsDietary Fats results in increased expression of NTRK2 mRNA22609946
D004041Dietary FatsDietary Fats analog results in decreased expression of NTRK2 protein28528080
D004041Dietary FatsDietary Fats results in increased expression of NTRK2 mRNA18721800
D019422Dietary SucroseDietary Sucrose results in increased expression of NTRK2 mRNA26033743
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of NTRK2 mRNA23999411
D004237DiuronDiuron results in decreased expression of NTRK2 mRNA25152437
C060297echinacosideechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]23189969
C060297echinacosidestaurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]]23189969
C060297echinacosideechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]23189969
C060297echinacosideechinacoside results in increased phosphorylation of NTRK2 protein23189969
C060297echinacosidestaurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK2 protein]23189969
D004732Endrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
C118739entinostatentinostat results in decreased expression of NTRK2 mRNA27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK2 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NTRK2 mRNA12075121|1590192
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of NTRK2 gene16495775
D005419FlavonoidsFlavonoids results in increased expression of NTRK2 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of NTRK2 protein15352031
D005472FluorouracilNTRK2 protein affects the susceptibility to Fluorouracil15352031
D005473FluoxetineFluoxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein21666748
D005473FluoxetineFluoxetine results in increased phosphorylation of NTRK2 protein22396798
D005473FluoxetineFluoxetine results in increased expression of NTRK2 mRNA15456934|8601816
D005473FluoxetineFluoxetine results in increased expression of NTRK2 mRNA alternative form15456934
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NTRK2 mRNA20938992
D019833GenisteinGenistein results in increased expression of NTRK2 mRNA12075121
C097367ginsenoside Rg3[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
C097367ginsenoside Rg3[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
C097367ginsenoside Rg3[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
C097367ginsenoside Rg3[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]24394491
C097367ginsenoside Rg3[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
C097367ginsenoside Rg3[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form"18606552
D003932HeroinHeroin results in increased expression of NTRK2 mRNA16710320
D017313FenretinideFenretinide results in decreased expression of NTRK2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NTRK2 mRNA26339600
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NTRK2 mRNA17997286
D006861Hydrogen PeroxideSodium Selenite promotes the reaction [Hydrogen Peroxide results in decreased expression of NTRK2 mRNA]17997286
D007099ImipramineImipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]22396798
D007099ImipramineImipramine results in increased phosphorylation of and results in increased activity of NTRK2 protein21666748
D007099ImipramineImipramine results in increased phosphorylation of NTRK2 protein22396798
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTRK2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NTRK2 mRNA25961927|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NTRK2 mRNA27432991
D007608Kainic AcidKainic Acid results in increased expression of NTRK2 mRNA19700661
D007608Kainic AcidKainic Acid results in decreased expression of NTRK2 mRNA16175575
D007649KetamineKetamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]8635431
D048628KetolidesKetolides analog results in increased expression of NTRK2 mRNA24967691
D007854LeadLead affects the splicing of NTRK2 mRNA28903495
D007854LeadLead results in decreased expression of [NTRK2 protein binds to NGFR protein]22345308
D007854LeadLead results in decreased phosphorylation of and results in decreased expression of NTRK2 protein22345308
C008261lead acetatelead acetate results in decreased expression of NTRK2 protein27492863
D001556Lindane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
D008070LipopolysaccharidesLipopolysaccharides results in decreased methylation of NTRK2 gene21212295
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of NTRK2 gene21212295
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]23963992
C025340manganese chloridemanganese chloride results in decreased expression of NTRK2 protein modified form25698507
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]23963992
D008713MethimazoleMethimazole results in decreased expression of NTRK2 mRNA17403546
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NTRK2 mRNA20938992
D008731MethoxychlorMethoxychlor results in increased methylation of NTRK2 gene23303685
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]16790237
C004925methylmercuric chloridemethylmercuric chloride affects the expression of NTRK2 mRNA21613230
D008774Methylphenidate[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
D009151Mustard GasMustard Gas results in decreased expression of NTRK2 mRNA15674843
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FGF2 protein results in increased expression of NTRK2 mRNA]16269011
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of NTRK2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NTRK2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NTRK2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NTRK2 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of NTRK2 mRNA18978301
D009281NaphthalenesNaphthalenes results in increased expression of NTRK2 protein17337753
D009525NiacinNiacin results in increased expression of NTRK2 protein20671245
D009532NickelNickel results in decreased expression of NTRK2 mRNA19130878
D009538Nicotinemethyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]16790237
D009538NicotineNicotine results in increased expression of NTRK2 protein16790237
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of NTRK2 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of NTRK2 mRNA25607892
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in decreased expression of NTRK2 mRNA23212921
D010100OxygenEPAS1 mutant form inhibits the reaction [Oxygen deficiency results in increased expression of NTRK2 mRNA]26095976
D010100OxygenOxygen deficiency results in increased expression of NTRK2 mRNA26095976
D010100OxygenOxygen deficiency results in increased expression of NTRK2 protein26095976
D010208PapaverinePapaverine results in increased expression of NTRK2 mRNA8601816
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]23963992
D010269ParaquatParaquat results in decreased expression of NTRK2 mRNA21371552
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]23963992
C494474perchlorateperchlorate results in decreased expression of NTRK2 mRNA17403546
D010634PhenobarbitalPhenobarbital results in decreased expression of NTRK2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of NTRK2 mRNA21335049
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NTRK2 mRNA26272509
D010830PhysostigminePhysostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]28499986
D010862PilocarpineKetamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]8635431
D010862PilocarpinePilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]19686240
D010862PilocarpinePilocarpine results in increased expression of NTRK2 mRNA15183516|8635431
D010862PilocarpineScopolamine Hydrobromide inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]8635431
C006253pirinixic acidpirinixic acid results in decreased expression of NTRK2 mRNA23811191
D010936Plant Extracts[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
D010936Plant Extracts[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
D010936Plant Extracts[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
D010936Plant Extracts[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]24394491
D010936Plant Extracts[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
D010936Plant Extracts[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
C545373ponatinibponatinib results in decreased activity of NTRK2 protein19878872
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
D011374ProgesteroneProgesterone results in decreased expression of NTRK2 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in increased expression of NTRK2 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of NTRK2 mRNA17403546
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of NTRK2 mRNA23274088
C043680ptaquilosideptaquiloside results in decreased expression of NTRK2 mRNA23274088
D011765PyruvaldehydePyruvaldehyde results in decreased expression of NTRK2 protein25933243
D011765Pyruvaldehydesulforafan inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein]25933243
C074679reboxetinereboxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein21666748
D012110Reserpinearsenic trioxide promotes the reaction [Reserpine results in decreased expression of NTRK2 protein]26114099
D012110ReserpineReserpine results in decreased expression of NTRK2 protein26114099
D015474IsotretinoinIsotretinoin results in increased expression of NTRK2 mRNA20436886
D020889RolipramRolipram results in increased expression of NTRK2 mRNA8601816
D012402Rotenoneechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]23189969
D012402RotenoneRotenone results in decreased phosphorylation of NTRK2 protein23189969
D012402Rotenonestaurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]]23189969
D012402Rotenoneechinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]23189969
D012402RotenoneRotenone results in decreased phosphorylation of NTRK2 protein23189969
D012524SarinSarin results in increased expression of NTRK2 mRNA19522546
D012601Scopolamine HydrobromideScopolamine Hydrobromide inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]8635431
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]23963992
D019821Simvastatin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA28263720
D012967Sodium Dodecyl SulfateNTRK2 SNP affects the susceptibility to Sodium Dodecyl Sulfate27206134
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of NTRK2 mRNA23274088
D018038Sodium SeleniteSodium Selenite promotes the reaction [Hydrogen Peroxide results in decreased expression of NTRK2 mRNA]17997286
D018038Sodium SeleniteSodium Selenite results in decreased expression of NTRK2 mRNA23274088
D012999SomanSoman results in increased expression of NTRK2 mRNA19281266
D053260SootSoot results in decreased expression of NTRK2 mRNA26551751
C049985staurosporine aglycone[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
C049985staurosporine aglycone[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
C049985staurosporine aglycone[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
C049985staurosporine aglycone[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [echinacoside inhibits the reaction [Rotenone results in decreased phosphorylation of NTRK2 protein]]23189969
C049985staurosporine aglycone[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
C049985staurosporine aglycone[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [echinacoside results in increased phosphorylation of NTRK2 protein]23189969
C049985staurosporine aglyconestaurosporine aglycone binds to and results in decreased activity of NTRK2 protein24394491
C049985staurosporine aglyconestaurosporine aglycone results in decreased activity of NTRK2 protein22381256
D013311StreptozocinAcetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]28499986
D013311StreptozocinPhysostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]28499986
D013311StreptozocinStreptozocin results in decreased phosphorylation of NTRK2 protein28499986
C016766sulforafansulforafan inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein]25933243
C016766sulforafansulforafan results in increased expression of NTRK2 protein25933243
C061133tamibarotene[tamibarotene co-treated with BDNF] results in increased expression of NTRK219182380
C061133tamibaroteneBDNF affects the reaction [tamibarotene results in increased phosphorylation of NTRK2 protein]19457078
C061133tamibarotenetamibarotene results in increased expression of NTRK219182380
C061133tamibarotenetamibarotene results in increased phosphorylation of NTRK2 protein19457078
D013729Terpenes[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]24394491
D013729Terpenes[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
D013729Terpenes[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
D013729Terpenes[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of NTRK2 protein modified form]24394491
D013729Terpenes[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [[Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3] results in decreased susceptibility to Chlorodiphenyl (54% Chlorine)]24394491
D013729Terpenes[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] results in decreased susceptibility to [Plant Extracts co-treated with Terpenes co-treated with ginsenoside Rg3]24394491
D013739TestosteroneTestosterone results in increased expression of NTRK2 protein17131419
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NTRK2 mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of NTRK2 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NTRK2 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NTRK2 mRNA19465110
C009495titanium dioxidetitanium dioxide affects the expression of NTRK2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NTRK2 mRNA20133372
D014050TolueneToluene results in increased expression of NTRK2 mRNA19932712
D014118Toxins, Biological"Toxins, Biological affects the expression of NTRK2 mRNA"19682533
D014191TranylcypromineTranylcypromine results in increased expression of NTRK2 mRNA8601816
D014212Tretinoin[Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNA17085092
D014212TretinoinTretinoin results in increased expression of NTRK2 mRNA16051641|2193413
D014212TretinoinTretinoin results in increased expression of NTRK2 protein16150056|2480644
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of NTRK2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NTRK2 mRNA"26552522
C022884undecaneundecane results in increased expression of NTRK2 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTRK2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of NTRK2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of NTRK2 mRNA22045034
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NTRK2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of NTRK2 mRNA25423262
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of NTRK2 mRNA25607892
C025643vinclozolinvinclozolin affects the expression of NTRK2 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of NTRK2 mRNA27188386
D015032ZincZinc deficiency results in increased expression of NTRK2 mRNA18356318
D015032ZincZinc deficiency results in decreased phosphorylation of NTRK2 protein20101602
C088658zoledronic acidzoledronic acid results in increased expression of NTRK2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005030neurotrophin receptor activity-IBA21873635  
GO:0005515protein binding-IPI17341134  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0042803protein homodimerization activity-ISS-  
GO:0043121neurotrophin binding-IBA21873635  
GO:0043121neurotrophin binding-IDA11738045  
GO:0043121neurotrophin binding-ISS-  
GO:0048403brain-derived neurotrophic factor binding-IBA21873635  
GO:0048403brain-derived neurotrophic factor binding-ISS-  
GO:0060175brain-derived neurotrophic factor-activated receptor activity-IBA21873635  
GO:0060175brain-derived neurotrophic factor-activated receptor activity-IMP15494731  
GO ID GO Term Qualifier Evidence PubMed
GO:0001570vasculogenesis-IEA-  
GO:0001764neuron migration-ISS-  
GO:0001934positive regulation of protein phosphorylation-TAS19036963  
GO:0007202activation of phospholipase C activity-TAS-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007528neuromuscular junction development-IEA-  
GO:0007612learning-ISS-  
GO:0007623circadian rhythm-IEA-  
GO:0007631feeding behavior-IEA-  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0014047glutamate secretion-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0021954central nervous system neuron development-ISS-  
GO:0021987cerebral cortex development-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030182neuron differentiation-ISS-  
GO:0031547brain-derived neurotrophic factor receptor signaling pathway-IMP15494731  
GO:0031547brain-derived neurotrophic factor receptor signaling pathway-TAS19036963  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0042490mechanoreceptor differentiation-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043087regulation of GTPase activity-ISS-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043410positive regulation of MAPK cascade-ISS-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0046548retinal rod cell development-IEA-  
GO:0046777protein autophosphorylation-ISS-  
GO:0048011neurotrophin TRK receptor signaling pathway-TAS-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0048935peripheral nervous system neuron development-IEA-  
GO:0050772positive regulation of axonogenesis-ISS-  
GO:0051896regulation of protein kinase B signaling-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0060041retina development in camera-type eye-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO:0099551trans-synaptic signaling by neuropeptide, modulating synaptic transmission-IBA21873635  
GO:0099551trans-synaptic signaling by neuropeptide, modulating synaptic transmission-IEA-  
GO:1903997positive regulation of non-membrane spanning protein tyrosine kinase activity-TAS-  
GO:1990090cellular response to nerve growth factor stimulus-IBA21873635  
GO:2000811negative regulation of anoikis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosome-ISS-  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA15494731  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0030424axon-IBA21873635  
GO:0031901early endosome membrane-IEA-  
GO:0043195terminal bouton-IEA-  
GO:0043197dendritic spine-IBA21873635  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
GO:0043679axon terminus-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-187015Activation of TRKA receptorsIEA
R-HSA-187024NGF-independant TRKA activationIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-9006115Signaling by NTRK2 (TRKB)TAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9024909BDNF activates NTRK2 (TRKB) signalingIEA
R-HSA-9025046NTF3 activates NTRK2 (TRKB) signalingIEA
R-HSA-9026357NTF4 activates NTRK2 (TRKB) signalingIEA
R-HSA-9026519Activated NTRK2 signals through RASIEA
R-HSA-9026527Activated NTRK2 signals through PLCG1TAS
R-HSA-9026527Activated NTRK2 signals through PLCG1IEA
R-HSA-9028335Activated NTRK2 signals through PI3KIEA
R-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3TAS
R-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3IEA
R-HSA-9032500Activated NTRK2 signals through FYNTAS
R-HSA-9032500Activated NTRK2 signals through FYNIEA
R-HSA-9032759NTRK2 activates RAC1TAS
R-HSA-9032759NTRK2 activates RAC1IEA
R-HSA-9032845Activated NTRK2 signals through CDK5IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16794563Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions. (2007 Jan)Sun DNeuropsychopharmacology
17503330A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. (2007 Jun)Lou XYAm J Hum Genet
16713586Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. (2007 Jan 1)Beuten JBiol Psychiatry
28512340Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. (2017 May 16)Yang HCSci Rep
19268276Genome-wide association study of smoking initiation and current smoking. (2009 Mar)Vink JMAm J Hum Genet
17200667Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. (2007 Dec)Xu KPharmacogenomics J
21618602Detecting genetic interactions for quantitative traits with U-statistics. (2011 Sep)Li MGenet Epidemiol
18534558Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. (2008 Dec 1)Li MDBiol Psychiatry
26384852Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)Levran OCNS Neurosci Ther