Gene info: ID 4920

Gene: ROR2

GENE ID: 4920

Synonyms: BDB|BDB1|NTRKR2

Description: receptor tyrosine kinase like orphan receptor 2

Gene type: protein-coding

Location: 9q22.31

dbXrefs: Ensembl:ENSG00000169071 MIM:602337 Vega:OTTHUMG00000020211 UniprotKB:Q01974

RefSeq: NG_008089.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.410e-1 (AD) 1.927e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4073735	chr9:91726133 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADAMTS6	0.553
TPK1	0.511
GSAP	0.501
ACOT9	0.473
DDX3X	0.462
TBC1D8	0.459
EMB	0.456
GK	0.455
KBTBD12	0.454
MIS18BP1	0.453

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C7orf61	-0.257
OR7C1	-0.235
HSPB9	-0.229
OR4F5	-0.22
TNFRSF13B	-0.215
ADAMTS18	-0.209
WDR38	-0.209
FAM222A	-0.204
MIA	-0.204
SLC25A48	-0.197

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of ROR2 mRNA	29067470
C547126	AZM551248	AZM551248 results in increased expression of ROR2 mRNA	22323515
C006780	bisphenol A	bisphenol A results in decreased expression of ROR2 mRNA	15223131
C006780	bisphenol A	bisphenol A affects the expression of ROR2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ROR2 gene	28505145
C018475	butyraldehyde	butyraldehyde results in increased expression of ROR2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of ROR2 promoter	22457795
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ROR2 mRNA	24763279
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ROR2 mRNA	22079256
C039281	furan	furan results in increased expression of ROR2 mRNA	27387713
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ROR2 mRNA	24763279
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of ROR2 mRNA	21396975
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ROR2 mRNA	26011545
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ROR2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ROR2 mRNA"	25554681
C046012	pentanal	pentanal results in increased expression of ROR2 mRNA	26079696
D010936	Plant Extracts	Plant Extracts results in decreased expression of ROR2 mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of ROR2 mRNA	21334430
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ROR2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of ROR2 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of ROR2 mRNA	22714537
D011374	Progesterone	Progesterone results in decreased expression of ROR2 mRNA	23012394
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ROR2 mRNA	24780913
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ROR2 mRNA	12377990
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ROR2 mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ROR2 mRNA	24928892
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ROR2 mRNA	17586704
D013853	Thioacetamide	Thioacetamide affects the methylation of ROR2 promoter	25151969
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ROR2 mRNA	28065790
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of ROR2 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ROR2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ROR2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ROR2 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased expression of ROR2 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of ROR2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ROR2 mRNA	24896083
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ROR2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IEA	-
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005109	frizzled binding	-	IEA	-
GO:0005515	protein binding	-	IPI	22939624
GO:0005524	ATP binding	-	IEA	-
GO:0017147	Wnt-protein binding	-	IBA	21873635
GO:0017147	Wnt-protein binding	-	IPI	19486338
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0031435	mitogen-activated protein kinase kinase kinase binding	-	IPI	18762249
GO:0046872	metal ion binding	-	IEA	-
GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	-	TAS	24431302

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001502	cartilage condensation	-	IEA	-
GO:0001756	somitogenesis	-	IEA	-
GO:0001934	positive regulation of protein phosphorylation	-	IBA	21873635
GO:0007165	signal transduction	-	TAS	1334494
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IEA	-
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	IEA	-
GO:0007224	smoothened signaling pathway	-	IEA	-
GO:0007254	JNK cascade	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007275	multicellular organism development	-	TAS	1334494
GO:0008285	negative regulation of cell proliferation	-	IMP	19486338
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0014002	astrocyte development	-	IEA	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030282	bone mineralization	-	IEA	-
GO:0030335	positive regulation of cell migration	-	IDA	19486338
GO:0030509	BMP signaling pathway	-	IEA	-
GO:0030538	embryonic genitalia morphogenesis	-	IEA	-
GO:0030539	male genitalia development	-	IEA	-
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0042472	inner ear morphogenesis	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043507	positive regulation of JUN kinase activity	-	IEA	-
GO:0045165	cell fate commitment	-	IEA	-
GO:0045651	positive regulation of macrophage differentiation	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	-
GO:0051968	positive regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	-
GO:0060395	SMAD protein signal transduction	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IEA	-
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IEA	-
GO:1900020	positive regulation of protein kinase C activity	-	IEA	-
GO:1905517	macrophage migration	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005874	microtubule	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	1334494
GO:0009986	cell surface	-	IEA	-
GO:0030424	axon	-	IBA	21873635
GO:0030425	dendrite	-	IEA	-
GO:0030669	clathrin-coated endocytic vesicle membrane	-	TAS	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0043235	receptor complex	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-4086400	PCP/CE pathway	TAS
R-HSA-4086400	PCP/CE pathway	IEA
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28521453	Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/beta-catenin and Wnt/PCP signaling pathways. (2017 May)	Wang C	Oncol Lett