Gene: ZBTB21

49854
ZNF295
zinc finger and BTB domain containing 21
protein-coding
21q22.3
Ensembl:ENSG00000173276 MIM:616485 Vega:OTTHUMG00000086789 UniprotKB:Q9ULJ3
NC_000021.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.273e-1 (AD)  6.101e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11702690chr21:41987559 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C18orf250.842
YTHDF30.832
DNAJB90.825
FYTTD10.823
TOP10.82
FAM210A0.819
HSPA130.815
LSM120.812
ELAVL10.812
YME1L10.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.518
OR4F29-0.461
ANPEP-0.322
COX4I2-0.289
CSAG1-0.274
VNN3-0.268
AKR1B15-0.259
P2RY14-0.255
HIGD1B-0.249
FCRL1-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of ZBTB21 mRNA23792671
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of ZBTB21 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZBTB21 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB21 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB21 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB21 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB21 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ZBTB21 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ZBTB21 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ZBTB21 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of ZBTB21 mRNA"23195993
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ZBTB21 mRNA"18687144
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZBTB21 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of ZBTB21 mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of ZBTB21 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of ZBTB21 mRNA21595052
D016572CyclosporineCyclosporine results in increased expression of ZBTB21 mRNA20106945|2556210
D002945CisplatinCisplatin results in increased expression of ZBTB21 mRNA27594783
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ZBTB21 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of ZBTB21 mRNA19167457
D019833GenisteinGenistein results in increased expression of ZBTB21 mRNA26865667
D006046GoldGold results in decreased expression of ZBTB21 mRNA25523186
C016517indole-3-carbinolindole-3-carbinol affects the expression of ZBTB21 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZBTB21 mRNA25613284
C045463leflunomideleflunomide results in increased expression of ZBTB21 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZBTB21 mRNA23649840
D009532NickelNickel results in increased expression of ZBTB21 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of ZBTB21 mRNA19167457
C016030pantogabpantogab results in increased expression of ZBTB21 mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB21 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of ZBTB21 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of ZBTB21 mRNA23091169
C045950propiconazolepropiconazole results in increased expression of ZBTB21 mRNA21278054
D011794QuercetinQuercetin results in increased expression of ZBTB21 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of ZBTB21 mRNA19073995
D012834SilverSilver results in increased expression of ZBTB21 mRNA26014281
D012834SilverSilver results in decreased expression of ZBTB21 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of ZBTB21 mRNA28595984
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ZBTB21 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZBTB21 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZBTB21 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZBTB21 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZBTB21 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZBTB21 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ZBTB21 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ZBTB21 mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of ZBTB21 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB21 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ZBTB21 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZBTB21 mRNA"26179874
D014520UrethaneUrethane results in increased expression of ZBTB21 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZBTB21 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ZBTB21 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ZBTB21 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ZBTB21 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ZBTB21 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0005515protein binding-IPI15324660  17353931  
GO:0008327methyl-CpG binding-IDA21029866  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal