Gene: P2RY6

5031
P2Y6
pyrimidinergic receptor P2Y6
protein-coding
11q13.4
Ensembl:ENSG00000171631 MIM:602451 Vega:OTTHUMG00000167969 UniprotKB:Q15077
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.384e-1 (AD)  7.178e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1790063chr11:73284867 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIGLEC90.794
CD1800.781
SECTM10.781
SIGLEC70.769
APOL60.768
LRRC250.764
GPR840.763
APOL40.762
IL18BP0.751
PML0.75

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.341
BFSP1-0.334
ZSCAN1-0.334
F7-0.325
SLC7A4-0.31
KIT-0.306
KCNIP3-0.305
CYP4A11-0.297
ATP2C2-0.293
SNX22-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of P2RY6 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of P2RY6 mRNA16788091
D000082AcetaminophenAcetaminophen affects the expression of P2RY6 mRNA17562736
D000255Adenosine Triphosphate"N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]"22129738
D000255Adenosine TriphosphateP2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]22129738
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of P2RY6 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of P2RY6 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of P2RY6 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of P2RY6 mRNA"23917077
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of P2RY6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RY6 mRNA20064835|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of P2RY6 mRNA22228805|2373587
D004958EstradiolEstradiol results in increased expression of P2RY6 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of P2RY6 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of P2RY6 mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of P2RY6 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RY6 mRNA20938992
D003300CopperCopper results in increased expression of P2RY6 mRNA19747488
D019327Copper SulfateCopper Sulfate results in increased expression of P2RY6 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of P2RY6 mRNA27523638
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of P2RY6 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of P2RY6 mRNA27392435
D002945CisplatinCisplatin results in increased expression of P2RY6 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of P2RY6 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of P2RY6 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of P2RY6 mRNA22609946
D004317DoxorubicinP2RY6 mRNA affects the susceptibility to Doxorubicin16044152
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of P2RY6 mRNA12655037
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RY6 mRNA20938992
C039281furanfuran results in increased expression of P2RY6 mRNA27387713
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of P2RY6 mRNA20044591
D006861Hydrogen Peroxide"N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]"22129738
D006861Hydrogen PeroxideP2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]22129738
D006918HydroxyureaHydroxyurea results in increased expression of P2RY6 mRNA27208086
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of P2RY6 mRNA27392435
C008261lead acetatelead acetate results in increased expression of P2RY6 mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of P2RY6 mRNA27339419
D008070LipopolysaccharidesP2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]]18523137
D008070LipopolysaccharidesP2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]18523137
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of P2RY6 mRNA20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of P2RY6 mRNA22129749
C523799MRK 003P2RY6 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of P2RY6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of P2RY6 mRNA"25554681
D009532NickelNickel results in increased expression of P2RY6 mRNA24768652|2558310
C541384N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea"N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea binds to and results in decreased activity of P2RY6 protein"22129738
C541384N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea"[N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea binds to and results in decreased activity of P2RY6 protein] which results in decreased expression of MAPK1 protein modified form"24418705
C541384N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea"[N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea binds to and results in decreased activity of P2RY6 protein] which results in decreased expression of MAPK3 protein modified form"24418705
C541384N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea"N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]]"22129738
C541384N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea"N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea binds to and results in decreased activity of P2RY6 protein"24418705
D000073878Palm OilPalm Oil results in decreased expression of P2RY6 mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of P2RY6 mRNA17426115
D010938Plant OilsPlant Oils results in decreased expression of P2RY6 mRNA23370395
C012526quercitrinquercitrin results in decreased expression of P2RY6 mRNA25193878
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of P2RY6 mRNA25895662
D012834SilverSilver results in decreased expression of P2RY6 mRNA27131904
C016104sodium bichromatesodium bichromate results in decreased expression of P2RY6 mRNA17685462
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P2RY6 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of P2RY6 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of P2RY6 mRNA20133372
D014303TrinitrotolueneTrinitrotoluene affects the expression of P2RY6 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of P2RY6 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of P2RY6 mRNA28818685
D014530Uridine DiphosphateP2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein]]18523137
D014530Uridine DiphosphateP2RY6 gene affects the reaction [Uridine Diphosphate promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]18523137
D014530Uridine DiphosphateP2RY6 gene affects the susceptibility to Uridine Diphosphate18523137
D014530Uridine DiphosphateP2RY6 gene mutant form inhibits the reaction [Uridine Diphosphate results in increased phosphorylation of MAPK1 protein]18523137
D014530Uridine DiphosphateP2RY6 gene mutant form inhibits the reaction [Uridine Diphosphate results in increased phosphorylation of MAPK3 protein]18523137
D014530Uridine DiphosphateUridine Diphosphate results in increased activity of P2RY6 protein18523137
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of P2RY6 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of P2RY6 mRNA26682919
D015032ZincZinc results in decreased expression of P2RY6 mRNA18316168

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS8670200  
GO:0005515protein binding-IPI25416956  
GO:0045028G-protein coupled purinergic nucleotide receptor activity-IEA-  
GO:0045029UDP-activated nucleotide receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-TAS8670200  
GO:0014911positive regulation of smooth muscle cell migration-IEA-  
GO:0030321transepithelial chloride transport-IEA-  
GO:0035589G-protein coupled purinergic nucleotide receptor signaling pathway-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA28277742  
GO:0071380cellular response to prostaglandin E stimulus-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IMP28277742  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8670200  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-417957P2Y receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28085253Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product. (2017 Apr 17)Poussin CChem Res Toxicol